Effective treatment and prevention of attempted suicide, anxiety, and aggressiveness with fluoxetine, despite proven use of androgenic anabolic steroids

Amaral, Julio Mario Xerfan do; Padilha, Marina; Chagas, Silvana V.; Baker, Julien S.; Mullen, Carrie; Neto, Leonardo Vieira; Neto, Francisco Radler de Aquino; Cruz, Marcelo Santos

doi:10.1002/dta.2912

Cited by 7 publications

(10 citation statements)

References 30 publications

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“…Although some controlled studies described a dose‐dependent association between AAS use and the onset of psychiatric symptoms, 13–15 this association is not always observed in ecological use of AAS 8 . In an attempt to reduce self‐report bias, recent studies have employed urinary analysis to detect and quantify the use of AAS in ecologic settings 16,17 . Since urinary analysis of androgens are not usually available in the clinical setting, seric sexual hormones affected by the use of AAS can also be used to investigate the likelihood of AAS use 18 .…”

Section: Introductionmentioning

confidence: 99%

No association between psychiatric symptoms and doses of anabolic steroids in a cohort of male and female bodybuilders

Amaral

Deslandes

Padilha

et al. 2022

Drug Testing and Analysis

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The use of androgenic-anabolic steroids (AAS) can be associated with psychiatric symptoms such as insomnia, anxiety and increased aggressiveness. Although dosedependent effects have been observed in some controlled studies, this association is not always seen in the ecological use of AAS. This study utilized WADA's steroid profile of suspicious use of AAS, urinary detection of AAS metabolites and measurement of sexual hormones to confirm recent use of AAS in a cohort of 103 bodybuilders (75 males, 28 females). The majority of participants (61.2%) presented symptoms of agitation, insomnia, increased aggressiveness or depression in the last 3 months. About one-third of participants presented scores on the HAM-A anxiety scale equivalent to moderate to severe symptoms of anxiety. A minority of participants (12.6%) presented high to moderate scores on the BPQ aggressiveness scale. The majority of participants (73.8%) presented hyperthymic temperament in the BRIEF-TEMPS scale.There was no significant difference in the presence of psychiatric symptoms between males and females and no association between psychiatric symptoms and estimated weekly doses of AAS. A negative association was observed between scores on the BPQ scale (verbal aggression, anger and total score) and the time of AAS use. We discuss differences of AAS use between male and female bodybuilders and the screening of AAS use in the general population. Our findings highlight the importance of mental health awareness among people using AAS.

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Section: Introductionmentioning

confidence: 99%

No association between psychiatric symptoms and doses of anabolic steroids in a cohort of male and female bodybuilders

Amaral

Deslandes

Padilha

et al. 2022

Drug Testing and Analysis

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“…The continuation or resumption of AAS use driven by symptoms of hypogonadism [ 97 – 100 ] was a significant finding, together with wider issues related to sexual health [ 101 ]. Harms associated with IPED use were commonly described [ 18 , 19 , 102 , 103 ], together with the risk environment [ 6 ] and efforts by individuals to mitigate these adverse consequences [ 104 ].…”

Section: Resultsmentioning

confidence: 99%

“…As part of service provision there were also calls for comprehensive testing including physiological indicators of harm [ 112 ] together with testing for BBVs [ 126 ] and psychosocial support regarding body image. Such testing for BBVs could draw upon the improved understanding of injecting beliefs and behaviours [ 101 ], including BBV risks [ 25 , 27 , 102 – 107 ], evident in the review. Information of nutrition and exercise [ 113 ], building self-esteem [ 97 ], psychological services to address dependence and muscle dysmorphia [ 82 , 97 ], and other body image vulnerabilities [ 59 ] were also considered necessary.…”

Section: Resultsmentioning

confidence: 99%

“…Research findings indicate a combination of routinely available data, survey data and other novel data collection methods should be employed [ 95 ], including online methodologies to gain a better understanding of the prevalence of use and associated behaviours [ 15 , 45 , 64 , 74 , 116 , 127 ]. Research is also needed into the clinical treatment of adverse effects [ 102 ] and how stigma and barriers within generic health services may be effectively addressed [ 112 ]. This is especially pertinent in relation BBV services [ 28 , 31 , 119 , 126 , 131 , 132 ] and sexual health services [ 31 ], including men who have sex with men and women who have sex with women [ 101 ].…”

Section: Discussionmentioning

confidence: 99%

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Generating evidence on the use of Image and performance enhancing drugs in the UK: results from a scoping review and expert consultation by the Anabolic Steroid UK network

et al. 2021

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Background The use of anabolic androgenic steroids (AAS) and associated image and performance enhancing drugs (IPEDs) is now a global phenomenon. There is a need to develop evidence to support the development of interventions to prevent the commencement of use, to minimise the potential harms or to support those in their cessation of use. While the United Kingdom (UK) is no exception to this issue, its public health and legislative response to the phenomenon differs to other countries and requires the examination of research specific to the UK. Therefore, a scoping review has been conducted to examine the recent relevant literature to help inform the development and evaluation of effective interventions to reduce the harmful use of IPEDs. Methods A comprehensive search strategy was developed for multiple bibliographic databases, supported by and iterative citation searching process and complimented by expert input from the Anabolic Steroid UK Network. Research conducted by or UK academics or within the UK were eligible, if published in the previous five years. Results In total 87 eligible outputs were identified, including 26 review articles, 25 qualitative papers and 24 quantitative papers. together with small numbers of clinical studies/case reports (6) and commentaries/correspondence (6). The most common topics of research were public health, treatment and harm reduction (41), followed by studies focusing on epidemiology, sub-groups of people using IPEDs and motivations for use (34). The studies illustrated the diverse populations of people who use a range of enhancement drugs including concomitant psychoactive drug use. A number of papers focused on blood borne viruses and associated issues, while others reported on the uptake of needle and syringe programmes. No effectiveness evaluations related to any aspect of treatment, harm reduction or other intervention were published during study period. Conclusion There is a need for the development of effectiveness evaluations of current interventions and any future service provision for people using image and performance enhancing drugs. While there have been no studies of this nature to date, this review illustrates the rich data that has been gathered through diverse methodologies, that will assist in the development of future effectiveness evaluations.

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“…However, they often ignore the possible adverse effects and the severity of their actions, and even if they know about them, they are willing to take risks. These include possible behavioral changes, anxiety [ 6 ], increased aggression [ 7 ], hepatotoxicity [ 8 ], cardiotoxicity [ 9 ], abnormalities of the reproductive system [ 10 , 11 ], and many others [ 12 ]. Particularly alarming, however, is a tendency to engage in criminal activities [ 13 ], along with the growing number of case reports of fatal medical conditions connected to the misuse of AASs [ 14 , 15 , 16 , 17 , 18 ], potentially resulting in sudden deaths [ 19 , 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Advances in the Determination of Anabolic-Androgenic Steroids: From Standard Practices to Tailor-Designed Multidisciplinary Approaches

Huml

Tauchen

Rimpelová

et al. 2021

Sensors

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Anabolic-androgenic steroids (AASs), a group of compounds frequently misused by athletes and, unfortunately, also by the general population, have lately attracted global attention; thus, significant demands for more precise, facile, and rapid AAS detection have arisen. The standard methods ordinarily used for AAS determination include liquid and gas chromatography coupled with mass spectrometry. However, good knowledge of steroid metabolism, pretreatment of samples (such as derivatization), and well-trained operators of the instruments are required, making this procedure expensive, complicated, and not routinely applicable. In the drive to meet current AAS detection demands, the scientific focus has shifted to developing novel, tailor-made approaches leading to time- and cost-effective, routine, and field-portable methods for AAS determination in various matrices, such as biological fluids, food supplements, meat, water, or other environmental components. Therefore, herein, we present a comprehensive review article covering recent advances in AAS determination, with a strong emphasis on the increasingly important role of chemically designed artificial sensors, biosensors, and antibody- and fluorescence-based methods.

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Effective treatment and prevention of attempted suicide, anxiety, and aggressiveness with fluoxetine, despite proven use of androgenic anabolic steroids

Cited by 7 publications

References 30 publications

No association between psychiatric symptoms and doses of anabolic steroids in a cohort of male and female bodybuilders

No association between psychiatric symptoms and doses of anabolic steroids in a cohort of male and female bodybuilders

Generating evidence on the use of Image and performance enhancing drugs in the UK: results from a scoping review and expert consultation by the Anabolic Steroid UK network

Advances in the Determination of Anabolic-Androgenic Steroids: From Standard Practices to Tailor-Designed Multidisciplinary Approaches

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