Effective Treatment of Acute GvHD After Haploidentical BMT With in vitro Expanded Murine CD4+CD25+ Regulatory T Cells

Haploidentical Bone Marrow Transplantation Without T-Cell Depletion

“…61 In recent clinical trials, the infusion of Tregs after haploidentical 62 and UCB 63 stem cell transplantation to prevent GVHD and promote immune reconstitution has produced promising results. The Peking University group 41 found that that a large population of CD62L ϩ naive Tregs (CD4 ϩ CD25 high CD45RA ϩ CD62L ϩ T cells) in allografts reduces the incidence of acute GVHD.…”