Effective treatment of Hailey-Hailey disease with topical tacrolimus?

Rabeni, Erika J.; Cunningham, Nancy M.

doi:10.1067/mjd.2002.126217

Cited by 43 publications

(20 citation statements)

References 5 publications

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“…To help minimize friction, weight should be maintained at appropriate levels and comfortable loose clothing should be worn. Medical line of therapy includes topical corticosteroids, topical antimicrobials, tacrolimus, calcipotriol, tacalcitol and, more recently, botulinum toxin [2,6,7]. Systemic therapy with antimicrobials, retinoids, and immunosuppresants like methotrexate and cyclosporine and dapsone have been tried, but the result with these treatments is not long lasting.…”

Section: Discussionmentioning

confidence: 99%

Hailey Hailey disease: a case report

Hassan¹,

Keen²

2012

Our Dermatol Online

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Hailey Hailey disease or Familial chronic benign pemphigus is a rare autosomal dominant acantholytic disease, clinically characterized by flaccid bullae and erosions in the intertriginous areas, mainly the axillary and inguinal region. We herein report a case of a forty year old female belonging to ethnic Kashmiri population with clinical and histopathological features suggestive of Hailey Hailey disease. StreszczenieChoroba Hailey Hailey lub przewlekła rodzinna łagodna pęcherzyca jest rzadką autosomalnie dominującą akantholityczną chorobą, klinicznie charakteryzującą się wiotkimi pęcherzami i nadżerkami w obszarach wyprzeniowych, głównie pach i pachwin. W niniejszym raporcie opisujemy przypadek czterdziestoletniej kobiety należącej do etnicznej ludności Kaszmiru z klinicznymi i histopatologicznymi cechami wskazującymi na chorobę Hailey Hailey.

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Section: Discussionmentioning

confidence: 99%

Hailey Hailey disease: a case report

Hassan¹,

Keen²

2012

Our Dermatol Online

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“…Recalcitrant Hailey-Hailey disease can be successfully treated with calcineurin inhibitors such as topical tacrolimus (FK506) and cyclosporine (Ormerod et al, 1991;Rabeni and Cunningham, 2002). While the major mechanism of action of these drugs is presumably the suppression of lymphocyte activation, a nonimmunomodulatory mechanism has also been proposed (Ormerod et al, 1991;Rabeni and Cunningham, 2002).…”

Section: To the Editormentioning

confidence: 98%

Hailey–Hailey Disease and Calcium: Lessons from Yeast

Szigeti

Kellermayer

2004

Journal of Investigative Dermatology

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“…Case reports are available about the efficacy of TCIs in autoimmune bullous dermatosis (pemphigus and bullous pemphigoid) [69][70][71] , Hailey-Hailey disease [72][73][74] , and pyoderma gangrenosum [75][76][77] .…”

Section: Bullous and Erosive Dermatosesmentioning

confidence: 99%

Potential New Indications of Topical Calcineurin Inhibitors

Luger

Paul

2007

Dermatology

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The topical calcineurin inhibitors pimecrolimus (Elidel®) and tacrolimus (Protopic®) were initially developed for the treatment of atopic eczema (atopic dermatitis), a chronic or chronically relapsing skin condition most prevalent in infants and children. Their main advantages compared with conventional topical corticosteroid therapy are that they are more selective in their mode of action, do not induce skin atrophy and are not associated with significant systemic absorption. In addition, topical calcineurin inhibitors may represent a useful alternative to topical corticosteroids for the treatment of a number of other inflammatory skin diseases. Preferred sites for the use of topical calcineurin inhibitors are areas such as the face, neck, flexures, and genital areas, which are more susceptible to topical corticosteroid side effects. The efficacy of topical calcineurin inhibitors has been demonstrated for flexural psoriasis, seborrhoeic, contact and hand eczema. Preliminary data also support the efficacy of topical calcineurin inhibitors in lichen planus, facial lupus erythematosus, autoimmune bullous dermatosis, and vitiligo. In these latter indications, controlled studies are needed to better understand the efficacy and safety of topical calcineurin inhibitors and their role in disease management.

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Effective treatment of Hailey-Hailey disease with topical tacrolimus?

Cited by 43 publications

References 5 publications

Hailey Hailey disease: a case report

Hailey Hailey disease: a case report

Hailey–Hailey Disease and Calcium: Lessons from Yeast

Potential New Indications of Topical Calcineurin Inhibitors

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