Effective treatment of recurrent orbital Rhabdoid Tumor with Predisposition Syndrome 1

Abstract

Rhabdoid tumor with predisposition syndrome 1 is a highly aggressive, rare genetic condition in young children. We report an 18-month-old child with bleeding from a second local recurrence of an orbital rhabdoid tumor. Due to the rarity of the syndrome there are no generally accepted treatment approaches, especially in tumor recurrences. As a rescue therapy, our patient received a combination of transarterial embolization and interstitial brachytherapy (BT). From the initiation of our treatment until his death, he experienced neither recurrent bleeding nor local tumor recurrence. The combination of embolization and BT might offer a safe palliative approach and could be considered as a possible alternative at an earlier stage.