Effective use of Biobrane as a temporary wound dressing prior to definitive split-skin graft in the treatment of severe burn: A retrospective analysis

Tan, Hannah; Wasiak, Jason; Paul, Eldho; Cleland, Heather

doi:10.1016/j.burns.2014.07.015

Cited by 22 publications

(6 citation statements)

References 16 publications

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“…Although, Biobrane is used for covering partial thickness burns in a single stage procedure, it has the drawback of being intolerant to contaminated wound beds. Integra, on the other hand, has good long term aesthetic and functional outcome, but is a two stage process with high cost and poor adhesion [97,98,99,100]. Integra may also include a high vulnerability to infection, graft loss and fluid entrapment, requiring fenestration of the tissue.…”

Section: Types Of Skin Substitutesmentioning

confidence: 99%

Advances in Skin Regeneration Using Tissue Engineering

Vig

Chaudhari

Tripathi

et al. 2017

IJMS

534

418

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Tissue engineered skin substitutes for wound healing have evolved tremendously over the last couple of years. New advances have been made toward developing skin substitutes made up of artificial and natural materials. Engineered skin substitutes are developed from acellular materials or can be synthesized from autologous, allograft, xenogenic, or synthetic sources. Each of these engineered skin substitutes has their advantages and disadvantages. However, to this date, a complete functional skin substitute is not available, and research is continuing to develop a competent full thickness skin substitute product that can vascularize rapidly. There is also a need to redesign the currently available substitutes to make them user friendly, commercially affordable, and viable with longer shelf life. The present review focuses on providing an overview of advances in the field of tissue engineered skin substitute development, the availability of various types, and their application.

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Section: Types Of Skin Substitutesmentioning

confidence: 99%

Advances in Skin Regeneration Using Tissue Engineering

Vig

Chaudhari

Tripathi

et al. 2017

IJMS

534

418

View full text Add to dashboard Cite

show abstract

“…52 Recent work suggests that a biosynthetic silicone wound dressing can be used to temporarily cover the wound; standardized protocols for this application have yet to be established. 53 Small burns, including deep partial and full-thickness burns, and those occurring on the face, hands, neck, and fingers where cosmesis is important should be covered with sheet split thickness skin graft. Larger burns can be covered with meshed split thickness grafts expanded to a ratio of 1:1, 2:1, 3:1, or 4:1.…”

Section: Acute Wound Carementioning

confidence: 99%

Hypertrophic scarring: the greatest unmet challenge after burn injury

et al. 2016

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Summary Improvements in acute burn care have enabled patients to survive massive burns which would have once been fatal. Now up to 70% of patients develop hypertrophic scars following burns. The functional and psychosocial sequelae remain a major rehabilitative challenge, decreasing quality of life and delaying reintegration into society. The current approach is to optimise the healing potential of the burn wound using targeted wound care and surgery in order to minimise the development of hypertrophic scarring. This approach often fails, and modulation of established scar is continued although the optimal indication, timing, and combination of therapies have yet to be established. The need for novel treatments is paramount, and future efforts to improve outcomes and quality of life should include optimisation of wound healing to attenuate or prevent hypertrophic scarring, well-designed trials to confirm treatment efficacy, and further elucidation of molecular mechanisms to allow development of new preventative and therapeutic strategies.

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“…As opposed to Transcyte®, Biobrane® is still widely used as a synthetic skin substitute as it is known for its success in the definitive management of partial thickness burns (Fig. 5 ) in many centres [ 68 – 70 ]. Biobrane® is the exact product of Transcyte® less the neonatal human fibroblasts and is also used as a dressing to hold meshed autografts and cultured keratinocyte suspension [ 69 , 71 ].…”

Section: Reviewmentioning

confidence: 99%

“…Currently, there is also an increasing trend to use Biobrane® as an alternative to cadaver allografts as temporizing dressings after excision of major burn injuries [ 68 , 69 , 73 ]. However, the caveat of using this technique is that the wound bed must be meticulously prepared to prevent any infection and there is still the lack of existing literature and published clinical protocols [ 68 ] to prove that it can be a worthy replacement of the human skin allografts, especially in the treatment of full thickness burn wounds.…”

Section: Reviewmentioning

confidence: 99%

Skin tissue engineering advances in severe burns: review and therapeutic applications

et al. 2016

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Current advances in basic stem cell research and tissue engineering augur well for the development of improved cultured skin tissue substitutes: a class of products that is still fraught with limitations for clinical use. Although the ability to grow autologous keratinocytes in-vitro from a small skin biopsy into sheets of stratified epithelium (within 3 to 4 weeks) helped alleviate the problem of insufficient donor site for extensive burn, many burn units still have to grapple with insufficient skin allografts which are used as intermediate wound coverage after burn excision. Alternatives offered by tissue-engineered skin dermal replacements to meet emergency demand have been used fairly successfully. Despite the availability of these commercial products, they all suffer from the same problems of extremely high cost, sub-normal skin microstructure and inconsistent engraftment, especially in full thickness burns. Clinical practice for severe burn treatment has since evolved to incorporate these tissue-engineered skin substitutes, usually as an adjunct to speed up epithelization for wound closure and/or to improve quality of life by improving the functional and cosmetic results long-term. This review seeks to bring the reader through the beginnings of skin tissue engineering, the utilization of some of the key products developed for the treatment of severe burns and the hope of harnessing stem cells to improve on current practice.

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Effective use of Biobrane as a temporary wound dressing prior to definitive split-skin graft in the treatment of severe burn: A retrospective analysis

Cited by 22 publications

References 16 publications

Advances in Skin Regeneration Using Tissue Engineering

Advances in Skin Regeneration Using Tissue Engineering

Hypertrophic scarring: the greatest unmet challenge after burn injury

Skin tissue engineering advances in severe burns: review and therapeutic applications

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