Effective Weight Control and Normalization of Metabolic Parameters after Laparoscopic Sleeve Gastrectomy: A Single Center Experience

Doğan, Murat; Tuğmen, Cem; Karaman, Kerem; Öztürk, Şafak; Ölmez, Mustafa; Karaca, Cezmi; Bademkiran, Ender; Görgün, Mehmet; Aydın, Cengiz

doi:10.5754/hge12566

Cited by 3 publications

(3 citation statements)

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“…A recent study demonstrated that LSG induces stable weight loss and resolution of obesity-associated comorbidities [31]. Our study is the first to assess the association of the rs9939609 FTO gene polymorphism and weight loss after LSG.…”

Section: Resultsmentioning

confidence: 95%

The effect of rs9939609 FTO gene polymorphism on weight loss after laparoscopic sleeve gastrectomy

Balasar¹,

Çakır

Erkal

et al. 2015

Surg Endosc

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Section: Resultsmentioning

confidence: 95%

The effect of rs9939609 FTO gene polymorphism on weight loss after laparoscopic sleeve gastrectomy

Balasar¹,

Çakır

Erkal

et al. 2015

Surg Endosc

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“…LSG has become increasingly popular around the world since 2000 [ 35 ]. LSG has been an effective, stand-alone therapy for morbidly obesity, with stable weight loss and resolution of obesity-associated comorbidities [ 36 , 37 ], but there have been few studies of the association between genetic factors and the outcomes of LSG. In 2016, Shanti et al.…”

Section: Personalized Obesity Treatment By Bariatric Surgerymentioning

confidence: 99%

From genetics and epigenetics to the future of precision treatment for obesity

Sun

Yang

et al. 2017

Gastroenterology Report

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Obesity has become a major global health problem, epitomized by excess accumulation of body fat resulting from an imbalance between energy intake and expenditure. The treatments for obesity range from modified nutrition and additional physical activity, to drugs or surgery. But the curative effect of each method seems to vary between individuals. With progress in the genetics and epigenetics of obesity, personalization of the clinical management of obesity may be at our doorstep. This review presents an overview of our current understanding of the genetics and epigenetics of obesity and how these findings influence responses to treatments. As bariatric surgery is the most effective long-term treatment for morbid obesity, we pay special attention to the association between genetic factors and clinical outcomes of bariatric surgery. Finally, we discuss the prospects for precision obesity treatment.

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“…LSG is a recently introduced restrictivetype bariatric procedure and is currently the most common surgical option employed in obesity management. Indeed, this technique has a good weight-loss efficacy and has been widely demonstrated to improve obesity related-comorbidities including type 2 diabetes, dyslipidemia, hypertension and many others [37][38][39]. However, the exact pathophysiological mechanisms behind its beneficial effects, beyond the mere weight reduction, are not completely understood.…”

Section: Endocrine Researchmentioning

confidence: 99%

Circulating Levels of the Adipokines Monocyte Chemotactic Protein-4 (MCP-4), Macrophage Inflammatory Protein-1β (MIP-1β), and Eotaxin-3 in Severe Obesity and Following Bariatric Surgery

et al. 2016

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The aim of the study was to investigate the involvement of the adipokines eotaxin-3, MIP-1β, and MCP-4 in obesity and related comorbidities and the modification of their circulating levels after bariatric surgery. Eighty severely obese subjects and 20 normal-weight controls were included in the study. Circulating levels of MCP-4, MIP-1β, and eotaxin-3, and the main clinical, biochemical, and instrumental parameters for the evaluation of cardiovascular and metabolic profile were determined in controls and in obese subjects at baseline and 10 months after surgery. Within the obese group at baseline, eotaxin-3 levels were higher in males than females and in smokers than non-smokers and showed a positive correlation with LDL-cholesterol, apolipoprotein B, and leptin. MIP-1β showed a positive correlation with age and leptin and a negative correlation with adiponectin and was an independent predictor of increased carotid artery intima-media thickness. MCP-4 levels were higher in obese subjects than controls and showed a positive correlation with body mass index, eotaxin-3, and MIP-1β. Bariatric surgery induced a marked decrease in all the 3 adipokines. MCP-4 is a novel biomarker of severe obesity and could have an indirect role in favoring sub-clinical atherosclerosis in obese patients by influencing the circulating levels of eotaxin-3 and MIP-1β, which are directly related to the main atherosclerosis markers and risk factors. The reduction of circulating levels of MCP-4, eotaxin-3, and MIP-1β could be one of the mechanisms by which bariatric surgery contributes to the reduction of cardiovascular risk in these patients.

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Effective Weight Control and Normalization of Metabolic Parameters after Laparoscopic Sleeve Gastrectomy: A Single Center Experience

Abstract: Results of this study demonstrate that LSG induces stable weight loss and resolution of obesity-associated comorbidities.

Cited by 3 publications

References 0 publications

The effect of rs9939609 FTO gene polymorphism on weight loss after laparoscopic sleeve gastrectomy

The effect of rs9939609 FTO gene polymorphism on weight loss after laparoscopic sleeve gastrectomy

From genetics and epigenetics to the future of precision treatment for obesity

Circulating Levels of the Adipokines Monocyte Chemotactic Protein-4 (MCP-4), Macrophage Inflammatory Protein-1β (MIP-1β), and Eotaxin-3 in Severe Obesity and Following Bariatric Surgery

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