Effectiveness and rapidity on olfatory fuction recovery in CRS patients treated with Dupilumab: a real life prospective controlled study

Efectividad real de la terapia biológica en el tratamiento de pacientes con rinosinusitis crónica con poliposis nasosinusal

“…Estos resultados en la vida real coinciden con los publicados por otros autores en numerosos estudios en los últimos dos años [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30]. Algunos trabajos han intentado comparar la efectidad real de diferebtes anticuerpos monoclonales [16][17][18].…”

“…Más numerosos son los trabajos sobre dupilumab en práctica clínica real [21][22][23][24][25][26][27][28][29]. Todos ellos demostraron un progreso adecuado con respecto a los cuestionarios de calidad de vida y el NPS en pacientes con RSCcPNS y asma.…”

Efficacy and Safety of Xylitol Nasal Irrigation after Functional Endoscopic Sinus Surgery: A Randomized Controlled Study

“…Our results showed that the concentration of IL6 significantly decreased after nasal irrigation in both the xylitol and saline groups, which may have been caused by the decreased inflammation of the sinonasal mucosa after nasal irrigation treatment. CRS has been endotyped based on three major types of cell-mediated effector immunity: types 1, 2 and 3 (T1, T2 and T3, respectively) [ 33 ]. The T1 endotype is categorized by an elevated expression of the T1 cytokine IFN-γ; the T2 endotype is categorized by elevated T2 cytokines (IL4, IL5 and IL13) as well as measures of eosinophilic cation protein (ECP); and the T3 endotype is categorized by elevated T3 cytokines (IL17A and IL17F) [ 34 ].…”

Taste and Smell Disorders: A Critical Look at Olfactory and Gustatory Dysfunction

“…In the United States, there are currently 2.7 million adults with an olfactory dysfunction and 1.1 million adults with a gustatory dysfunction. These dysfunctions are also known to have a higher prevalence in older adults, with more than half of those between the ages of 65 and 80 years and more than 75% of those over 80 years old having a demonstrable decline in their sense of smell [ 1 , 2 ] These conditions, which affect the vital human senses of smell and taste, have unfortunately been overlooked and overshadowed amidst the focus on more widely-known diseases and treatment breakthroughs [ 3 , 4 , 5 , 6 ]. However, disorders of smell and taste deserve dedicated attention and research, as they can severely impact patients’ quality of life, safety, nutrition, and emotional well-being [ 7 ].…”