Effectiveness and Safety Differences of Isoxsuprine and Nifedipine as Tocolytics in the Risk of Preterm Labor

Oktavia, Nur; Yulistiani, Yulistiani; Markus, Unedo H; Mamo, Hendriette Irene

doi:10.20473/fmi.v53i4.7153

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…A metaanalysis found that women with cervical length <15 mm has a high risk of developing preterm labor within 7 days. 23,24 This study found that administration of Isoxsuprine is better than Nifedipine in preventing the shortening of cervical length in threatened preterm labor. This is consistent with study by Jaju et al…”

Section: Discussionmentioning

confidence: 85%

Comparison of Nifedipine and Isoxsuprine to Cervical Length in Threatened Preterm Labor

Pramadana

Rachmawati

Pusianawati

2021

Obgynia

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Objective: This study aimed to determine differences in cervical length changes between administration of nifedipine and isoxsuprine. Method: Subjects of the study were pregnant women who meet the inclusion criteria (n=16). Treatments were given for 48 hours. Parameters measured was the cervical length before and after the administration of nifedipine and isoxsuprine. This study was conducted in Dr. Hasan Sadikin General Hospital from January until April 2020. Result: Less shortening of the cervical length after administration of tocolytic isoxsuprin for 48 hours compared with tocolytic nifedipine and statistically significant with p value of 0.0001 (p<0.05) using Paired T tests. Conclusion: Isoxsuprin is more effective to prevent shortening of the cervical length compared to nifedipine in cases of threatened preterm labor. Key word: Nifedipine, Isoxsuprine, cervical length, threatened preterm labor

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Section: Discussionmentioning

confidence: 85%

Comparison of Nifedipine and Isoxsuprine to Cervical Length in Threatened Preterm Labor

Pramadana

Rachmawati

Pusianawati

2021

Obgynia

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“…Nifedipine is known as an antihypertensive drug, but in pregnancy apart from being an antihypertensive nifedipine can prevent or treat the occurrence of preeclampsia or Partus Prematurus Imminens (PPI) as well as a tocolytic agent in pregnancy. The success rate of nifedipine therapy as a tocolytic in Partus Prematurus Imminens (PPI) patients at Sanglah Central General Hospital Denpasar in 2014-2016 was 47.05% (Oktavia, 2017).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Use Off Label Drugs At the Obstetrics and Gynecology Polyclinic at Bandung Private General Hospital

Rahayu,

Santika

2024

ijgor

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Off label drugs are drugs outside the indications listed on the label or outside the approval by the authorized institution. This research is a non-experimental type of research that is presented in a quantitative descriptive manner with retrospective data collection. The research sample is the same as the population (total sampling), namely all prescriptions containing off label drugs from an obstetrics and gynecology polyclinic at a private public hospital in Bandung district from May to August 2021. The purpose of the study was to evaluate the use of off label drugs in the indication category based on age, domicile, the type and use of off label drugs. The data obtained from this study were 154 drug users. off label, based on the age range of adolescents 27 (18%), adults 111 (72%), middle 16 (10%), while based on domicile most of the patients came from Baleendah sub-district 37 (24%). The types of drugs used were Mefenamic Acid 38%, Dexamethasone 3%, Metformin 12%, Misoprostol 23%, Nifedipine 8% and Ondansetron 16%. Patients using off label drugs are more common in adults with the drug used is mefenamic acid.

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“…Similar observations have been noted in previous studies. [ 15 16 17 ] Various attempts have been made to design a stratification tool to determine the risk of preterm delivery based on risk factors. [ 18 19 ]…”

Section: Discussionmentioning

confidence: 99%

Oral nifedipine and parenteral isoxsuprine in arresting preterm labor

Ray

Kshirsagar

2022

Journal of Family Medicine and Primary Care

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Objective: To compare the efficacy of oral nifedipine and parenteral isoxsuprine in arresting preterm labor. Considering the paucity of studies comparing these two agents, a comparative analysis is obligatory. Materials and methods: Eighty antenatal women in the gestational age range of 28–37 weeks, with regular uterine contractions, cervical dilatation ≤3 cm, and <50% cervical effacement, admitted with complaints of preterm labor pain were randomized to receive either 40 mg isoxsuprine or 20 mg nifedipine. Efficacy of the drugs was measured in terms of arrest of preterm labor, prolongation of pregnancy, and the days gained by infant before birth. Results: Isoxsuprine showed increased lowering of systolic blood pressure (SBP), diastolic blood pressure (DBP), and slightly higher maternal pulse rate, but higher fetal pulse rate post-administration in comparison to nifedipine ( P < 0.05). Isoxsuprine was significantly associated with more side effects. Pregnancy was more prolonged in the nifedipine group (25 days) than in the isoxsuprine group (19 days) ( P < 0.05). The birth weight of neonates in group B was more than that of neonates in group A ( P < 0.05). At 5 min after birth, none of the neonates in group B had an Appearance, Pulse, Grimace, Activity, and Respiration (APGAR) abnormal score <7, compared to neonates in group A. Majority of neonates in group A showed tachycardia and respiratory distress syndrome (RDS) (17.5% and 12.5%, respectively), compared to group B (12.5% and 7.5%, respectively). The overall success rate was better in group B (86.8%) compared to group A (80%). Conclusion: Nifedipine was slightly more effective in arresting preterm labor with fewer side effects, compared to isoxsuprine.

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Effectiveness and Safety Differences of Isoxsuprine and Nifedipine as Tocolytics in the Risk of Preterm Labor

Cited by 4 publications

References 7 publications

Comparison of Nifedipine and Isoxsuprine to Cervical Length in Threatened Preterm Labor

Comparison of Nifedipine and Isoxsuprine to Cervical Length in Threatened Preterm Labor

Evaluation of the Use Off Label Drugs At the Obstetrics and Gynecology Polyclinic at Bandung Private General Hospital

Oral nifedipine and parenteral isoxsuprine in arresting preterm labor

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