Effectiveness and Safety of Acupuncture Moxibustion Therapy Used in Breast Cancer‐Related Lymphedema: A Systematic Review and Meta‐Analysis

Jin, Han Seung; Xiang, Yuying; Feng, Yuqian; Zhang, Yiting; Liu, Shan; Ruan, Shanming; Zhou, Huamiao

doi:10.1155/2020/3237451

Cited by 5 publications

(7 citation statements)

References 25 publications

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“…1). 1‐134 Of those, 65 of 94 publications (69.1%) were included in the qualitative analysis because they reported at least 1 type of AE,…”

Section: Resultsmentioning

confidence: 99%

“…Some meta-analyses that focus on the effectiveness of acupuncture for treating symptoms in patients with breast cancer or pain in oncological patients do report AEs and conclude that acupuncture is a safe intervention. 25,31,32 A prospective, observational study on nononcological patients by Witt et al in 2009 indicated that acupuncture was a relatively safe treatment option 14 : common adverse effects were bleeding These were crossover trials that had insufficient reporting for inclusion in the meta-analysis.…”

Section: Discussionmentioning

confidence: 99%

“…10 In some systematic reviews, no data concerning intervention-related AEs of acupuncture treatment are reported [16][17][18][19][20][21][22] or they are not systematically analyzed. [23][24][25][26][27][28][29] Only a few meta-analyses [30][31][32] deal with adverse effects/ AEs, and those are limited to patients who have breast cancer or a symptom like chemotherapy-induced peripheral neuropathy. 33 To examine the safety of acupuncture in cancer care, we systematically accessed and metaanalyzed the frequency of AEs of acupuncture in RCTs of patients with cancer and cancer survivors.…”

Section: Introductionmentioning

confidence: 99%

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Safety of acupuncture in oncology: A systematic review and meta‐analysis of randomized controlled trials

Höxtermann

Haller

Aboudamaah

et al. 2022

Cancer

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Background Acupuncture is frequently used to treat the side effects of cancer treatment, but the safety of this intervention remains uncertain. The current meta‐analysis was conducted to assess the safety of acupuncture in oncological patients. Methods The PubMed, Cochrane Central Register of Controlled Trials, and Scopus databases were searched from their inception to August 7, 2020. Randomized controlled trials in oncological patients comparing invasive acupuncture with sham acupuncture, treatment as usual (TAU), or any other active control were eligible. Two reviewers independently extracted data on study characteristics and adverse events (AEs). Risk of bias was assessed using the Cochrane Risk of Bias Tool. Results Of 4590 screened articles, 65 were included in the analyses. The authors observed that acupuncture was not associated an with increased risk of intervention‐related AEs, nonserious AEs, serious AEs, or dropout because of AEs compared with sham acupuncture and an active control. Compared with TAU, acupuncture was not associated with an increased risk of intervention‐related AEs, serious AEs, or drop out because of AEs but was associated with an increased risk for nonserious AEs (odds ratio, 3.94; 95% confidence interval, 1.16‐13.35; P = .03). However, the increased risk of nonserious AEs compared with TAU was not robust against selection bias. The meta‐analyses may have been biased because of the insufficient reporting of AEs in the original randomized controlled trials. Conclusions The current review indicates that acupuncture is as safe as sham acupuncture and active controls in oncological patients. The authors recommend researchers heed the CONSORT (Consolidated Standards of Reporting Trials) safety and harm extension for reporting to capture the side effects and better investigate the risk profile of acupuncture in oncology. Lay Summary According to this analysis, acupuncture is a safe therapy for the treatment of patients with cancer. Acupuncture seems to be safe compared with sham acupuncture and active controls.

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“…1). 1‐134 Of those, 65 of 94 publications (69.1%) were included in the qualitative analysis because they reported at least 1 type of AE,…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Safety of acupuncture in oncology: A systematic review and meta‐analysis of randomized controlled trials

Höxtermann

Haller

Aboudamaah

et al. 2022

Cancer

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“…This review conducted a meta-analysis based on different control methods to avoid clinical heterogeneity of samples that may affect the results of the study. In contrast to previous meta-analyses, 9,10,35,36 strict filtering criteria were implemented for the studies included in this review. For the included RCTs, the intervention group had to be ordinary acupuncture and/or ordinary moxibustion, in order to eliminate the effects of other measures (such as electroacupuncture, laser, traditional Chinese medicine, massage, and cupping, among others) to the extent possible.…”

Section: Discussionmentioning

confidence: 99%

Effects of Acupuncture and Moxibustion on Breast Cancer-Related Lymphedema: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Gao

Han

et al. 2021

Integr Cancer Ther

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Objective: The aim of this systematic review and meta-analysis of randomized controlled trials (RCTs) was to evaluate the effects of acupuncture and moxibustion (AM) in women with breast cancer-related lymphedema (BCRL). Methods: We retrieved RCTs published before January 24, 2021, from the MEDLINE, EMBASE, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), Chongqing VIP (VIP), and Wanfang databases. RCTs that compared acupuncture and/or moxibustion intervention with other treatments were included. A random effects or fixed effects model was used based on the heterogeneity findings. Study quality was evaluated using the Cochrane risk of bias tool. Results: We included 14 RCTs in the analyses, of which 4 RCTs adopted acupuncture, 4 RCTs used moxibustion, and the rest used both. AM significantly reduced arm circumference at the elbow crease compared to routine care (Mean deviation (MD) = −7.26, 95% confidence interval (CI) = −8.30 to −6.21, P < .00001). There was a significant difference between AM and diosmin tablets in the effective index for upper limb lymphedema (MD = 24.68, 95% CI = 24.82-30.53, P < .00001), the range of motion of the shoulder during protraction (MD = 6.77, 95% CI = 2.81-10.73, P = .0008), and adduction (MD = 4.17, 95% CI = 1.02-7.32, P = .01). There was a significant difference between moxibustion and pneumatic circulation (MD = −0.51, 95% CI = −0.85 to −0.17, P = .003) in the visual analog score (VAS) for swelling. Finally, compared to the blank control, acupuncture reduced the VAS for pain (MD = −1.33, 95% CI = −1.52 to −1.15, P < .00001; heterogeneity ( I2) = 0%, P = .57). Conclusion: Our results suggest that AM is effective in the treatment of BCRL. AM may reduce arm circumference at the elbow crease (compared to routine care), increase effective index for upper limb lymphedema (compared to oral diosmin tablets), improve the range of motion of the shoulder during protraction and adduction (compared to oral diosmin tablets), and decrease the VAS for both swelling (compared to pneumatic circulation) and pain (compared to blank control).

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“…For example, EA treatment at the GV20 and ST36 acupoints improves model animal learning and memory abilities and protects against hippocampal injury, inhibits inflammatory factors, and regulates brain activity via antioxidative damage [ 25 , 26 ]. An increasing number of countries have endorsed the efficacy and safety of EA treatment [ 27 , 28 ]. These considerations led us to further explore the potential improving cognitive effects of EA treatment on CI in our SAMP8 mouse model.…”

Section: Discussionmentioning

confidence: 99%

Electroacupuncture Improves Cognitive Function in Senescence-Accelerated P8 (SAMP8) Mice via the NLRP3/Caspase-1 Pathway

et al. 2020

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Background. Clinically, electroacupuncture (EA) is the most common therapy for aging-related cognitive impairment (CI). However, the underlying pathomechanism remains unidentified. The aims of this study were to observe the effect of EA on cognitive function and explore the potential mechanism by which EA acts on the NLRP3/caspase-1 signaling pathway. Main Methods. Thirty male SAMP8 mice were randomly divided into the model, the 2 Hz EA and 10 Hz EA groups. Ten male SAMR1 mice were assigned to the control group. Cognitive function was assessed through the Morris water maze test. Hippocampal morphology and cell death were observed by HE and TUNEL staining, respectively. The serum IL-1β, IL-6, IL-18, and TNF-α levels were measured by ELISA. Hippocampal NLRP3, ASC, caspase-1, GSDM-D, IL-1β, IL-18, Aβ, and tau proteins were detected by Western blotting. Key Findings. Cognitive function, hippocampal morphology, and TUNEL-positive cell counts were improved by both EA frequencies. The serum IL-1β, IL-6, IL-18, and TNF-α levels were decreased by EA treatment. However, 10 Hz EA reduced the number of TUNEL-positive cells in the CA1 region and serum IL-1β and IL-6 levels more effectively than 2 Hz EA. NLRP3/caspase-1 pathway-related proteins were significantly downregulated by EA, but 2 Hz EA did not effectively reduce ASC protein expression. Interestingly, both EA frequencies failed to reduce the expression of Aβ and tau proteins. Significance. The effects of 10 Hz EA at the GV20 and ST36 acupoints on the NLRP3/caspase-1 signaling pathway may be a mechanism by which this treatment relieves aging-related CI in mice.

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Effectiveness and Safety of Acupuncture Moxibustion Therapy Used in Breast Cancer‐Related Lymphedema: A Systematic Review and Meta‐Analysis

Cited by 5 publications

References 25 publications

Safety of acupuncture in oncology: A systematic review and meta‐analysis of randomized controlled trials

Safety of acupuncture in oncology: A systematic review and meta‐analysis of randomized controlled trials

Effects of Acupuncture and Moxibustion on Breast Cancer-Related Lymphedema: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Electroacupuncture Improves Cognitive Function in Senescence-Accelerated P8 (SAMP8) Mice via the NLRP3/Caspase-1 Pathway

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