Effectiveness and Safety of Calcium Hydroxylapatite With Lidocaine for Improving Jawline Contour

Abstract

Background: One of the early signs of aging is loss of jawline contour. Not all cases require surgical intervention and soft-tissue augmentation with injectable fillers may restore the profile and youthful appearance of the jawline. Objective: To demonstrate the effectiveness and safety of calcium hydroxylapatite with lidocaine [CaHA (+); Radiesse ® (+)] to improve the contour of jawline after deep (subdermal and/or supraperiosteal) injection. Methods: Healthy eligible patients with moderate or severe ratings on the Merz Jawline Assessment Scale (MJAS) were randomized 2:1 to treatment with CaHA (+) or to control. Patients in the control group remained untreated until week 12, then received delayed treatment. Touch-ups were allowed in both groups, and re-treatment was allowed in the treatment group only. Effectiveness was evaluated on the MJAS, patient and investigator Global Aesthetic Improvement Scales, and FACE-Q ™ questionnaires. Adverse events were recorded over a 60-week period. Results: Treatment response rate (≥1-point MJAS improvement) was 93/123 (75.6%) for the treatment group and 5/57 (8.8%) for the control/delayed-treatment group at week 12. The difference between response rates was statistically significant (P<0.0001), showing superiority of treatment over control. Satisfaction with aesthetic improvement was reported by patients and treating investigators throughout the study. A total of 76/113 (67.3%) patients who responded to treatment 12 weeks after initial injection also demonstrated persistent improvement 48 weeks after initial treatment. The study demonstrated a favorable safety profile, with no reported unexpected adverse events. Conclusions: CaHA (+) is a safe and effective treatment for improving the contour of the jawline.

A systematic review of Radiesse/calcium hydroxylapatite and carboxymethylcellulose: evidence and recommendations for treatment of the face

“…A total of 1,515 records were identified through the initial search, of which 92 full texts were assessed for eligibility and 20 studies were included in the qualitative synthesis, regarding face treatment (Figure 1). 10,16–38 …”

“…23,24 Jawline and marionette lines Table 4 summarizes studies about the jawline and marionette lines. [26][27][28] Moradi et al 26 proved a significant ≥1-point improvement of the Merz jawline assessment scale in patients treated with CaHA/CMC in RCT versus non-treated. In 70% of patients showing improvements at 12 weeks, results were persistent at 48 weeks.…”

From Nasolabial Folds to Pan-facial Rejuvenation—The Evolution of Fillers in my Career

“…17 Rasch-transformed scores on the FACE-Q Satisfaction with Lower Face and Jawline increased from 21.5 (18.9) baseline to 75.2 (22.3) at week 12, indicating that patients were satisfied with how their jawlines appeared postfiller treatment. 17 More recently, Juvederm Volux XC became the first FDA-approved hyaluronic acid filler injectable. 18 In this pivotal clinical randomized controlled trial, Juvederm improved jawline definition by 69.9% (102/146 patients) at 6 months, with 81.5% (119/146) of participants reporting satisfaction with their sculpted jawline appearance compared to 12.2% at baseline.…”

“…A randomized, controlled, evaluator-blinded trial was conducted with 180 patients aged 26 to 65 years of age who presented with moderate to severe loss of jawline fullness and an interest in improved jawline contour and volume. 17 Median injection volume for each side of the jawline was 1.80 mL. 17 The treatment group responder rate at week 12 was 75.6% (93/123), while the response rate in the control/delayedtreatment group was 8.8% (5/57) (p < 0.0001).…”

“…17 Median injection volume for each side of the jawline was 1.80 mL. 17 The treatment group responder rate at week 12 was 75.6% (93/123), while the response rate in the control/delayedtreatment group was 8.8% (5/57) (p < 0.0001). 17 Rasch-transformed scores on the FACE-Q Satisfaction with Lower Face and Jawline increased from 21.5 (18.9) baseline to 75.2 (22.3) at week 12, indicating that patients were satisfied with how their jawlines appeared postfiller treatment.…”