Effectiveness and safety of different schemes of perioperative prophylaxis withheparins in spine surgery

Abstract

To study of effectiveness and safety of different schemes of perioperative prophylaxis against thromboembolism with heparins 36 patients who has been undergone spinal surgery under general anaesthesia were divided into three equal groups. Heparin, enoxaparin, and bemiparine were administrated to patients of h-group, e-group, and b-group, respectively, in routine regimen. Large ecchymosis, thromboembolic events, and bleeding were registered for first 5 postoperative days. Only the former has shown statistically significant differences between hand b-groups (p=0.01). In addition, emergence of large ecchymosis was higher in e-group compared with b-group (p=0.047). Thus, our data have suggested effectiveness and safety of different schemes of perioperative prophylaxis with heparins in spine surgery.