Effectiveness and Safety of Hwangchil–Unripe Bokbunja Extract Mixture on Blood Pressure: A Randomized Double-Blind Placebo-Controlled Clinical Trial

Shen, Lei; Gwak, Si Ra; Joo, Jong Cheon; Ha, Ki Chan; Park, Yu Kyung; Kim, Sunoh; Park, Soo Jung

doi:10.1089/jmf.2020.4820

Cited by 3 publications

(6 citation statements)

References 39 publications

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“…As a result, they have not observed any toxicity of DPL up to 2000 mg/kg/day in 14-day repeated-dose toxicity and 13-week subchronic toxicity study in rats [13]. In addition, we reported that there were no adverse effects in the DPL intake group through other clinical studies [14]. Although this study did not provide direct toxicity results, it is expected that there will be no toxicity according to the results of previous reports.…”

Section: Discussionmentioning

confidence: 46%

“…The toxicity of DPL may be one factor involved in intestinal inflammatory or epithelial cell responses. Many researchers have tested and reported the cytotoxicity, acute toxicity, and chronic toxicity of DPL in various cells and animals [13,14,50]. As a result, they have not observed any toxicity of DPL up to 2000 mg/kg/day in 14-day repeated-dose toxicity and 13-week subchronic toxicity study in rats [13].…”

Section: Discussionmentioning

confidence: 99%

“…The leaves were dried in the hot air oven at 55 • C for 24 h. For the aqueous leaf extract, 100 g of the leaves were boiled in 2000 mL distilled water (1:20, w/v) at 100 • C for 4 h and filtered through a filter paper (Whatman No. 1), then freeze-drying the extract [13,14]. Normally, 27 g extract was obtained from 100 g of dried leaves of D. morbiferus.…”

Section: Preparation Of Extractsmentioning

confidence: 99%

“…Previously, we proposed the use of quercetin and kaempferol as chemical markers for the quality control of D. morbiferus after analyzing parts, seasons, and extraction methods [11]. Moreover, we reported the antiobesity effect [12] and antihypertensive effect [13,14] of DPL. However, study about the laxative effect of DPL is still largely unknown.…”

Section: Introductionmentioning

confidence: 99%

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Laxative Effects of a Standardized Extract of Dendropanax morbiferus H. Léveille Leaves on Experimental Constipation in Rats

Na¹,

Lee²,

Kim³

et al. 2021

Medicina

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Background and Objectives: This study aimed at investigating the laxative effects of a standardized aqueous extract of Dendropanax morbiferus H. Lév. on two different constipation rat models. Materials and Methods: Animal studies were conducted with low-fiber diet-induced and loperamide-induced constipation animal models, and isolated colons were used in ex vivo analysis to determine the changes in colonic motility caused by D. morbiferus H. Lév. leaf extract (DPL). Results: The results showed that DPL administration significantly improved certain reduced fecal parameters (number, weight, and water content of the stools) in a both low-fiber diet and loperamide-induced constipation models without adverse effects of diarrhea. The laxative effect of DPL was confirmed to improve the charcoal excretion time upon DPL treatment in a low-fiber diet or loperamide-induced constipation model through gastrointestinal (GI) motility evaluation using the charcoal meal test. In addition, when DPL was administered to RAW264.7 cells and loperamide-induced constipation model rats, the production of prostaglandin E2 (PGE2) increased significantly in cells and tissue. Furthermore, DPL dose-dependently stimulated the spontaneous contractile amplitude and frequency of the isolated rat colon. Conclusion: Although our study did not provide information on the acute or chronic toxicity of DPL, our results demonstrated that DPL can effectively promote defecation frequency and rat colon contraction, providing scientific evidence to support the use of DPL as a therapeutic application. However, further toxicity studies of DPL are needed prior to the initiation of clinical trials and clinical applications.

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Section: Discussionmentioning

confidence: 46%

Section: Discussionmentioning

confidence: 99%

Section: Preparation Of Extractsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Laxative Effects of a Standardized Extract of Dendropanax morbiferus H. Léveille Leaves on Experimental Constipation in Rats

Na¹,

Lee²,

Kim³

et al. 2021

Medicina

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“…특히 미숙과 복분자는 완숙과 복분자보다 엘라그산 함유량이 더 높고, 5% 주 정을 이용한 추출을 통해 가장 높은 엘라그산이 추출되 는 표준 추출법 개발을 사전연구를 통해 검증 14) 함으로 서 전통적인 소재로서 복분자는 미숙과 상태의 과실이 사용된 것에 대한 과학적 근거를 제시해 주고 있다. 우 리는 고혈압 동물모델에서 5% 주정으로 추출한 미숙과 복분자 추출물(unripe Rubus coreanus, 5-uRCK)의 혈압 강하 효과 15) 와 인체적용시험을 통한 혈압강하 효과 16) 를 보고하였다. 고지방 식이(high fat diet) 모델에서 수행한 선행연구에서는 5-uRCK 처리에 따라 지방세포의 지질 축적 억제 및 분해촉진 효과에 의한 항비만 [17][18][19] 및 항 고콜레스테롤혈증 효과 20,21) 를 보고하였고, 인체적용시험 을 통해 총콜레스테롤 및 low density lipoprotein (LDL) 콜레스테롤 수치를 감소시킴을 확인하였다 22) .…”

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Effects of Unripe Rubus Coreanus Extract on Upper Body Obesity: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Kim

Baek

et al. 2021

J Korean Med Rehabil

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Antioxidant-Rich Dietary Intervention Improves Cardiometabolic Profiles and Arterial Stiffness in Elderly Koreans with Metabolic Syndrome

et al. 2022

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Purpose Oxidative stress plays an important role in the pathogenesis of chronic metabolic diseases. This study investigated the effect of the antioxidant-rich dietary intervention on oxidative stress, metabolic parameters, and arterial stiffness in elderly Koreans with metabolic syndrome (MetS). Materials and Methods Thirty-one subjects with MetS were enrolled and randomly divided into dietary intervention group and control group. Subjects in the intervention group received three meal boxes prepared with antioxidant-rich ingredients every day for 4 weeks, and subjects in the control group maintained their usual diets. Anthropometric and various biochemical parameters related to oxidative stress, inflammation, and MetS were assessed. Brachial-ankle pulse wave velocity (baPWV) and fat measurement using computed tomography were also conducted before and after 4 weeks. Results There were significant differences in waist circumference, visceral to subcutaneous fat ratio, lipid peroxidation, oxidized low density lipoprotein (oxLDL), systolic and diastolic blood pressure, lipid parameters, advanced glycation end products, and baPWV between before and after the study in the experimental group (all p <0.05). Significant inter-group differences were observed between the experimental and control group in terms of the differences in body mass index, waist circumference, oxygen radical absorbance capacity, protein carboxylation, lipid peroxidation, oxLDL, blood pressure, lipid parameters, and baPWV between before and after the study (all p <0.05). Conclusion Antioxidant-rich dietary intervention for a 4-week period ameliorated the state of oxidative stress and improved the components of MetS including central obesity, dyslipidemia, hypertension, and arterial stiffness in elderly Koreans with MetS.

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Effectiveness and Safety of Hwangchil–Unripe Bokbunja Extract Mixture on Blood Pressure: A Randomized Double-Blind Placebo-Controlled Clinical Trial

Cited by 3 publications

References 39 publications

Laxative Effects of a Standardized Extract of Dendropanax morbiferus H. Léveille Leaves on Experimental Constipation in Rats

Laxative Effects of a Standardized Extract of Dendropanax morbiferus H. Léveille Leaves on Experimental Constipation in Rats

Effects of Unripe Rubus Coreanus Extract on Upper Body Obesity: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Antioxidant-Rich Dietary Intervention Improves Cardiometabolic Profiles and Arterial Stiffness in Elderly Koreans with Metabolic Syndrome

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