Effectiveness and safety of low‐dose oral immunotherapy protocols in paediatric milk and egg allergy

Feasibility and Safety of the Early Introduction of Allergenic Foods in Asian Infants with Eczema

“…However, the PETIT Study showed that the development of allergies to hen’s eggs can be prevented by starting 50 mg of egg protein consumption at the age of 6 months and gradually increasing the dose to 250 mg of egg protein [ 3 ], even in the presence of sensitization to hen’s eggs. We have also previously reported that children who developed food allergies were able to increase their tolerable dose threshold by the continuous consumption of a very small amount of the allergen, such as 1/100 of the initial threshold dose [ 32 , 33 ]. Therefore, we believe that continued consumption, even in small amounts, contributes to tolerance in potentially allergic children.…”

Predictors of oral food challenge outcome in young children

“…4 We defined severe cases as those with maximum Sampson score ≥3, where cases were classified as positive by PRACTALL criteria. We defined 'regular intake history' as daily intake below the reaction threshold (including low-dose oral immunotherapy 6 below the reaction threshold) without absolute elimination at home. We examined the relationship between the aforementioned variables for each group, OFC results, and symptom severity.…”