Effectiveness and safety of metoclopramide in treatment of intractable hiccup: a protocol of systematic review and meta-analysis

Abstract

IntroductionHiccup is a common disease that not only occurred on adults but also on infants, which can severely do harm to patients’ physical and psychological health. Metoclopramide has been reported to have effects on intractable hiccup. However, there is a limited evidence that describes the efficacy and safety of metoclopramide in the treatment of intractable hiccup. The aim of this article is to obtain evidence on the effectiveness and safety of metoclopramide in treating patients with intractable hiccup.Methods and analysisWe will search the following databases, including PubMed, Cochrane Library, Embase, Web of Science, CBM, Wan-fang, VIP database, CNKI and MEDLINE from their inception to 11 November 2021. All the randomised controlled trials associated with metoclopramide in treating intractable hiccup will be included. Articles screened, selected and extracted will be performed by two researchers independently. The risk of bias will be assessed by using the Cochrane Collaboration. We will carry out the meta-analysis by using RevMan V.5.4 software.PROSPERO registration numberCRD42021293000.

An Unusual Cause of Intractable Hiccups

“…Dopamine antagonists such as metoclopramide can be effective because they block receptors located on the reflex arc. 18 , 28 Finally, 5-hydroxytryptamine antagonism, through medications such as risperidone, has been shown to alleviate hiccups by decreasing stimulation of the vagus nerve. 17 , 29 Nonpharmacological treatments, such as phrenic nerve blockage, have shown success, but it comes with dangerous risks including respiratory compromise.…”