Effectiveness and safety of nutritional supplements in the treatment of hereditary retinal dystrophies: a systematic review

Brito-García, N; Pino-Sedeño, Tasmania del; Trujillo-Martín, M.M.; Coco, Rosa M.; Rúa, Enrique Rodríguez de la; Cura-González, Isabel del; Serrano-Aguilar, P.

doi:10.1038/eye.2016.286

Cited by 24 publications

(17 citation statements)

References 34 publications

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“…Treatment with vitamin A in these cases is not straight-forward, as there is a fear of accumulation of excessive amounts of toxic retinoids that are formed as byproducts of vitamin A pathways. A good example of this toxicity is ABCA4-retinopathy where toxic products of vitamin A accumulate excessively in the retina [9,23,[76][77][78].…”

Section: Retinal Diseases Directly or Indirectly Associated With Vita...mentioning

confidence: 99%

The Role of Vitamin A in Retinal Diseases

Sajovic

Meglič

Glavač

et al. 2022

IJMS

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Vitamin A is an essential fat-soluble vitamin that occurs in various chemical forms. It is essential for several physiological processes. Either hyper- or hypovitaminosis can be harmful. One of the most important vitamin A functions is its involvement in visual phototransduction, where it serves as the crucial part of photopigment, the first molecule in the process of transforming photons of light into electrical signals. In this process, large quantities of vitamin A in the form of 11-cis-retinal are being isomerized to all-trans-retinal and then quickly recycled back to 11-cis-retinal. Complex machinery of transporters and enzymes is involved in this process (i.e., the visual cycle). Any fault in the machinery may not only reduce the efficiency of visual detection but also cause the accumulation of toxic chemicals in the retina. This review provides a comprehensive overview of diseases that are directly or indirectly connected with vitamin A pathways in the retina. It includes the pathophysiological background and clinical presentation of each disease and summarizes the already existing therapeutic and prospective interventions.

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Section: Retinal Diseases Directly or Indirectly Associated With Vita...mentioning

confidence: 99%

The Role of Vitamin A in Retinal Diseases

Sajovic

Meglič

Glavač

et al. 2022

IJMS

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“…These nutraceutical supplements have been associated with a slowing in the progression of geographic atrophy and a reduced probability of experiencing advances in the stages of age-related macular degeneration. Different formulations of vitamins, polyunsaturated fatty acids, minerals and other compounds have been proposed for inherited retinal dystrophies, supported by modest evidence regarding their clinical efficacy [ 111 ].…”

Section: Retinal Drugs For Non-exudative Diseasesmentioning

confidence: 99%

Molecular Features of Classic Retinal Drugs, Retinal Therapeutic Targets and Emerging Treatments

Arrigo

Bandello

2021

Pharmaceutics

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The management of exudative retinal diseases underwent a revolution due to the introduction of intravitreal treatments. There are two main classes of intravitreal drugs, namely anti-vascular endothelial growth factors (anti-VEGF) and corticosteroids molecules. The clinical course and the outcome of retinal diseases radically changed thanks to the efficacy of these molecules in determining the regression of the exudation and the restoration of the macular profile. In this review, we described the molecular features of classic retinal drugs, highlighting the main therapeutic targets, and we provided an overview of new emerging molecules. We performed a systematic review of the current literature available in the MEDLINE library, focusing on current intravitreal molecules and on new emerging therapies. The anti-VEGF molecules include Bevacizumab, Pegaptanib, Ranibizumab, Aflibercept, Conbercept, Brolucizumab, Abicipar-pegol and Faricimab. The corticosteroids approach is mainly based on the employment of triamcinolone acetonide, dexamethasone and fluocinolone acetonide molecules. Many clinical trials and real-life reports demonstrated their efficacy in exudative retinal diseases, highlighting differences in terms of molecular targeting and pharmacologic profiles. Furthermore, several new molecules are currently under investigation. Intravitreal drugs focus their activity on a wide range of therapeutic targets and are safe and efficacy in managing retinal diseases.

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“…Due to the antioxidant capacity of LA, which has been argued previously, it could be a candidate for preventing the photoreceptors death. In fact, a variety of antioxidants has been tested as a treatment for RP in, both, animal [94,95,96] and human models [97,98].…”

Section: Lipoic Acid: An Antioxidant and Anti-inflammatory Moleculementioning

confidence: 99%

Progesterone, Lipoic Acid, and Sulforaphane as Promising Antioxidants for Retinal Diseases: A Review

2019

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Oxidative stress has been documented to be a key factor in the cause and progression of different retinal diseases. Oxidative cellular unbalance triggers a sequence of reactions which prompt cell degeneration and retinal dysfunction, both hallmarks of several retinal pathologies. There is no effective treatment, yet, for many retinal diseases. Antioxidant treatment have been pointed out to be an encouraging palliative treatment; the beneficial effects documented involve slowing the progression of the disease, a reduction of cell degeneration, and improvement of retinal functions. There is a vast information corpus on antioxidant candidates. In this review, we expose three of the main antioxidant treatments, selected for their promising results that has been reported to date. Recently, the sulforaphane, an isothiocyanate molecule, has been unveiled as a neuroprotective candidate, by its antioxidant properties. Progesterone, a neurosteroid has been proposed to be a solid and effective neuroprotective agent. Finally, the lipoic acid, an organosulfur compound, is a well-recognized antioxidant. All of them, have been tested and studied on different retinal disease models. In this review, we summarized the published results of these works, to offer a general view of the current antioxidant treatment advances, including the main effects and mechanisms described.

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Effectiveness and safety of nutritional supplements in the treatment of hereditary retinal dystrophies: a systematic review

Abstract: The hereditary retinal dystrophies (HRDs) are a group of genetically determined disorders that result in loss of the visual function.

Cited by 24 publications

References 34 publications

The Role of Vitamin A in Retinal Diseases

The Role of Vitamin A in Retinal Diseases

Molecular Features of Classic Retinal Drugs, Retinal Therapeutic Targets and Emerging Treatments

Progesterone, Lipoic Acid, and Sulforaphane as Promising Antioxidants for Retinal Diseases: A Review

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