Effectiveness and Safety of Traditional Chinese Medicine in Treating COVID-19: Clinical Evidence from China

Xing, Dongmei; Liu, Zhibin

doi:10.14336/ad.2021.0906

Cited by 30 publications

(21 citation statements)

References 23 publications

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“…In the process of treating COVID-19 and preventing COVID-19 transmission, Chinese physicians have accumulated rich experiences and created three Chinese patent medicines (i.e., Jinhua Qinggan Granules, Lianhua Qingwen Capsule, and Xuebijing Injection) and three herbal prescriptions (i.e., Qingfei Paidu Decoction, Huashi Paidu Recipe, and Xuanfeibaidu Recipe). Furthermore, TCM treatment plays a significant role in reducing the overall mortality rate, shortening the duration of hospitalization, improving the clinical symptoms, preventing disease progression, obtaining favorable treatment outcomes in patients with severe COVID-19, reducing the positive rate of viral nucleic acid testing and improving quality of life and immunity ( Xing and Liu, 2021 ). When network pharmacology is applied to study the mechanism of Traditional Chinese medicine on COVID-19, the multi-component, multi-target and multi-pathway treatment characteristics of network pharmacology can be fully reflected, whether it is single drug or prescription of Traditional Chinese medicine.…”

Section: Discussionmentioning

confidence: 99%

Application of network pharmacology in the study of the mechanism of action of traditional chinese medicine in the treatment of COVID-19

Zheng

Xue²,

Wang³

et al. 2022

Front. Pharmacol.

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Network pharmacology was rapidly developed based on multidisciplinary holistic analysis of biological systems, which has become a popular tool in traditional Chinese medicine (TCM) research in recent years. Its characteristics of integrity and systematization provide a new approach for the study on complex TCM systems, which has many similarities with the holistic concept of TCM. It has been widely used to explain the mechanism of TCM treatment of diseases, drug repositioning, and interpretation of compatibility of TCM prescriptions, to promote the modernization of TCM. The use of TCM have provided crucial support on prevention and treatment of diseases such as the famous “three medicines and three prescriptions”. Furthermore, TCM has become an important part of the treatment of COVID-19 and is one of the main contents of the “Chinese plan” to fight the epidemic. The current review demonstrated the role of TCM in treating diseases with multiple components, multiple targets, and multiple pathways, interprets the connotation of TCM treatment method selection based on pathogenesis and also discusses the application of network pharmacology in the study of COVID-19 treatment in TCM including single drug and prescription. However, there are still some shortcomings such as the lack of experimental verification and regular upgrading of the TCM pharmacology network. Therefore, we must pay attention to the characteristics of TCM and develop a network pharmacology method suitable for TCM system research when applying network pharmacology to TCM research.

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Section: Discussionmentioning

confidence: 99%

Application of network pharmacology in the study of the mechanism of action of traditional chinese medicine in the treatment of COVID-19

Zheng

Xue²,

Wang³

et al. 2022

Front. Pharmacol.

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“…Various Chinese patent medicine and Chinese herbal decoction (Table 3 ) were used in the included studies of this review, such as Lianhua Qingwen capsules, Jinhua Qingan granule, Xuanfei Baidu decoction, Xuebijing injection etc. Research showed CHM played a significant role in the fight against COVID-19 by improving immunity [ 72 ]. Network pharmacological strategy integrates molecular docking analyses indicated Lianhua Qingwen capsule can act by regulating immune response, apoptosis and virus infection, thereby exerting potential therapeutic effects in COVID-19.…”

Section: Discussionmentioning

confidence: 99%

The efficacy and safety of combined chinese herbal medicine and western medicine therapy for COVID-19: a systematic review and meta-analysis

Xie

Zhang

et al. 2022

Chin Med

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Objective To systematically review the clinical efficacy and safety of Chinese herbal medicine (CHM) with and without Western medicine (WM) for different severity of COVID-19. Methods CNKI, PubMed, Wanfang Database, ClinicalTrails.gov, Embase, ChiCTR and ICTRP were searched from 01 Jan, 2020 to 30 Jun, 2021. Two authors independently assessed all the randomized clinical trials (RCTs) for trial inclusion, data extraction and quality assessment. Meta-analysis was conducted using Review Manager software (RevMan 5.4.1). Evidence was assessed using Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Primary outcomes included total effectiveness rate. Secondary outcomes included improvements in symptom improvement and total adverse event rate. Different severity of COVID-19 patients was assessed in subgroup analysis. This study was registered with INPLASY, INPLASY202210072. Results 22 high quality RCTs involving 1789 participants were included. There were no trial used CHM alone nor compare placebo or no treatment. Compared with WM, combined CHM and WM (CHM-WM) treatment showed higher total effectiveness rate, lower symptom scores of fever, cough, fatigue, dry throat and pharyngalgia, shorter mean time to viral conversion, better Computerized Tomography (CT) image and blood results, fewer total adverse events and worse conditions (P < 0.05). Subgroup analysis showed that the total effectiveness rate of combined CHM-WM group was significantly higher than WM group, especially for mild and moderate patients. No significant differences in mortality and adverse events were found between combined CHM-WM and WM treatment. No serious adverse events and long-term outcomes were reported. Conclusion Current evidence supported the therapeutic effects and safety of combined CHM-WM treatment on COVID-19, especially for patients with mild and moderate symptoms. Long-term effects of therapy are worthy in further study.

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“…Moreover, in the 74187 confirmed cases of SARS-CoV-2 infection reported in China, the effective rate of receiving TCM treatment was more than 90%, and its main effect was to significantly improve and shorten the course of disease, delay disease progression, and reduce mortality ( 248 ). At the same time, traditional Chinese medicine has also been confirmed to have a low incidence of adverse reactions and often self-healing in the treatment of COVID-19 patients ( 249 ). Given that, TCM is a valuable resource for combating the epidemic of SARS-CoV-2.…”

Section: Potential Therapeutic Strategies and Promising Anti-sars-cov...mentioning

confidence: 99%

“…We know that TCM prescriptions are produced in long-term exploration and practice, and their compatibility, toxicity, safety and other issues can be guaranteed. However, the abovementioned problems exist when the active ingredients and monomers of TCM are used ( 249 , 255 ). We hope that TCM can be more widely used in the treatment of COVID-19, but at the same time, safety issues such as compatibility, toxicity, and adverse reactions of active ingredients and monomers of TCM should also be more studied and explored ( 256 ).…”

Section: Potential Therapeutic Strategies and Promising Anti-sars-cov...mentioning

confidence: 99%

Advances in Pathogenesis, Progression, Potential Targets and Targeted Therapeutic Strategies in SARS-CoV-2-Induced COVID-19

Zhou

Huang

et al. 2022

Front. Immunol.

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As the new year of 2020 approaches, an acute respiratory disease quietly caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as coronavirus disease 2019 (COVID-19) was reported in Wuhan, China. Subsequently, COVID-19 broke out on a global scale and formed a global public health emergency. To date, the destruction that has lasted for more than two years has not stopped and has caused the virus to continuously evolve new mutant strains. SARS-CoV-2 infection has been shown to cause multiple complications and lead to severe disability and death, which has dealt a heavy blow to global development, not only in the medical field but also in social security, economic development, global cooperation and communication. To date, studies on the epidemiology, pathogenic mechanism and pathological characteristics of SARS-CoV-2-induced COVID-19, as well as target confirmation, drug screening, and clinical intervention have achieved remarkable effects. With the continuous efforts of the WHO, governments of various countries, and scientific research and medical personnel, the public’s awareness of COVID-19 is gradually deepening, a variety of prevention methods and detection methods have been implemented, and multiple vaccines and drugs have been developed and urgently marketed. However, these do not appear to have completely stopped the pandemic and ravages of this virus. Meanwhile, research on SARS-CoV-2-induced COVID-19 has also seen some twists and controversies, such as potential drugs and the role of vaccines. In view of the fact that research on SARS-CoV-2 and COVID-19 has been extensive and in depth, this review will systematically update the current understanding of the epidemiology, transmission mechanism, pathological features, potential targets, promising drugs and ongoing clinical trials, which will provide important references and new directions for SARS-CoV-2 and COVID-19 research.

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Effectiveness and Safety of Traditional Chinese Medicine in Treating COVID-19: Clinical Evidence from China

Cited by 30 publications

References 23 publications

Application of network pharmacology in the study of the mechanism of action of traditional chinese medicine in the treatment of COVID-19

Application of network pharmacology in the study of the mechanism of action of traditional chinese medicine in the treatment of COVID-19

The efficacy and safety of combined chinese herbal medicine and western medicine therapy for COVID-19: a systematic review and meta-analysis

Advances in Pathogenesis, Progression, Potential Targets and Targeted Therapeutic Strategies in SARS-CoV-2-Induced COVID-19

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