Effectiveness and Safety of Treatment with Neodymium:YAG Laser 1064 nm in Patients with Classic and Epidemic Kaposi Sarcoma

Silvestri, Martina; Latini, Alessandra; Parola, Ilaria Lesnoni La; Messina, C; Nisticò, Steven Paul; Cameli, Norma

doi:10.3390/bioengineering9030106

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…Furthermore, systemic toxicity may develop, particularly in patients with multiple lesions [ 2 , 3 ]. Local treatments for CKS include the use of CO2, argon, Q-switched 755-nm Alexandrite, pulsed-dye, and Nd:YAG lasers [ 9 , 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…Another study by Silvestri et al explored the efficacy of Nd:YAG laser treatment in patients with stage 1–2 CKS skin lesions and AIDS-related KS lesions (epidemic form) receiving antiretroviral therapy [ 10 ]. The treatment was effective in 80% of the patients, with minimal side effects such as post-inflammatory hyperpigmentation and mild hypotrophic scars [ 10 ]. Similar to our findings, Nd:YAG laser therapy was deemed a safe and effective treatment option.…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of Long-Pulsed Nd:YAG Laser for Classic Kaposi’s Sarcoma: A Dermoscopic Study

Bostancı,

Aygun Alızada,

Farabi

et al. 2024

Dermatology Practical &Amp; Conceptual

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Introduction: Classic Kaposi’s sarcoma (CKS) is a chronic and indolent skin tumor. Because CKS has a low mortality rate but can have a significant impact on quality of life, it is important to choose safe, long-term treatments with minimal side effects. Objectives: The aim was to assess the efficacy of long-pulsed Nd:YAG laser therapy in treating CKS based on clinical and dermoscopic observations. Methods: Forty-two nodular lesions from three CKS patients (stage 4) were treated using a long-pulsed Nd:YAG laser with a spot size ranging from 3 to 7 mm, a fluence of 200–250 j/cm2, and a pulse duration lasting between 10 and 20 milliseconds in one or two sessions. Patients were photographed clinically and dermoscopically before the procedure, immediately after the procedure, and at 1, 6, and 12 months after the procedure. Results: All participants displayed significant clinical and dermoscopic improvements, and all lesions healed within 2–3 weeks, resulting in only minor atrophic scars. No instance of recurrence was found among any of the patients during the 1-year follow-up. Conclusions: Nd:YAG laser therapy may prove to be an effective therapeutic alternative for both early and advanced-stage CKS, specifically in instances of stubborn cutaneous lesions or patients receiving systemic therapy. The treatment results in quick improvement, typically within 2–3 weeks, and is well tolerated. Nd:YAG laser therapy could provide potential benefits for HIV-positive patients as it is free from immunosuppression, easy to apply to recurring lesions, and demonstrates overall effectiveness and safety.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Efficacy of Long-Pulsed Nd:YAG Laser for Classic Kaposi’s Sarcoma: A Dermoscopic Study

Bostancı,

Aygun Alızada,

Farabi

et al. 2024

Dermatology Practical &Amp; Conceptual

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Management and Future Therapeutic Perspectives of Classic Kaposi’s Sarcoma: An Evidence-Based Review

Denaro,

Indini,

Brambilla

et al. 2024

OTT

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Background Kaposi sarcoma (KS) is a cutaneous neoplasm of endothelial origin. The causative agent is the human herpes virus-8 (HHV-8) which, combined with an immune system impairment, causes cell proliferation. To date, high-quality evidence and treatment recommendations for the management of KS are confined to the acquired immune deficiency syndrome (AIDS)-related KS, while the clinical approach to the treatment of classic KS (CKS) is based on small retrospective case series and the experience of clinicians in selected referral centers. Materials and Methods A search of the English literature was conducted through PubMed/MEDLINE databases for studies regarding CKS diagnosis, staging, and treatment, published between January 1990 and September 2023. Results Overall, 122 out of 565 articles were selected. Based on the results of this literature review, we proposed indications regarding the recommended flow chart for diagnosis, staging, and follow-up of patients with CKS. We assess available evidences regarding topic, locoregional, and systemic treatments of CKS. We also provide a focus on novel treatment strategies and therapeutic approaches currently under evaluation in clinical trials. Conclusion CKS is a rare disease and its management requires a multidisciplinary assessment. Treatment in referral centers and enrolment in clinical trials might impact on outcomes.

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Effectiveness and Safety of Treatment with Neodymium:YAG Laser 1064 nm in Patients with Classic and Epidemic Kaposi Sarcoma

Cited by 2 publications

References 15 publications

Efficacy of Long-Pulsed Nd:YAG Laser for Classic Kaposi’s Sarcoma: A Dermoscopic Study

Efficacy of Long-Pulsed Nd:YAG Laser for Classic Kaposi’s Sarcoma: A Dermoscopic Study

Management and Future Therapeutic Perspectives of Classic Kaposi’s Sarcoma: An Evidence-Based Review

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