Effectiveness and safety of Wendan decoction for post-stroke depression

Abstract

Background: Post-stroke depression (PSD) refers to a series of affective disorder syndromes that occur after stroke and are often accompanied by physical symptoms. PSD presents with low mood and lack of interest as the main characteristics along with the symptoms of stroke. The physical symptoms of PSD include sleep disorder, loss of appetite, and reluctance to communicate. Although Wendan decoction has been suggested to be effective in the treatment of PSD, there is no meta-analysis providing evidence for the usefulness of Wendan decoction for treating PSD. Methods: The following electronic databases will be searched: the Cochrane Library, PubMed, EMBASE, China National Knowledge Infrastructure, Wan Fang databases, Chinese Biomedical Literature Database, and China Science and Technology Journal Database. Each database will be searched from its inception to November 2021. Two independent researchers will conduct study selection, data extraction, and risk bias assessment. Any discrepancies will be resolved through consultation with a third researcher. If the included data are suitable, we will conduct a meta-analysis using RevMan v5.4 software. Results: In this systematic review, the effectiveness and safety of Wendan decoction in the treatment of PSD will be evaluated. Conclusion: The findings of this meta-analysis will provide evidence-based data for the application of Wendan decoction in the treatment of PSD. Ethics and dissemination: Individual patient data and privacy will not be involved in this research,so ethics approval is not required. INPLASY registration number: INPLASY2021110018

Effect of acupuncture combined with antidepressants on post-stroke depression: A network meta-analysis of nine acupuncture therapy

“…( 61–63 ). PSD not only hinders the recovery of neurological and cognitive functions of stroke patients, but also causes great mental suffering and seriously affects the quality of life of patients ( 64 , 65 ). Acupuncture plays an important role in the treatment of PSD as a reliable and safe alternative therapy.…”

Wendan decoction in the treatment of nonalcoholic fatty liver disease: A systematic review and meta-analysis

“…Wendan decoction (WDD), a TCM formulation that was first described in “Ji Yan Fang” during the Southern and Northern Dynasties, was adopted by the National Administration of TCM in 2018 and included in the “Ancient Classical Chinese Medicine Formula Catalogue (First Edition)” ( Wang et al, 2021 ). WDD primarily consists of Ban Xia, Zhu Ru, Zhi Shi, Chen Pi, Fu Ling, and Gan Cao with the Latin names Rhizoma Pinelliae (RP), Caulis Bambusae in Taeniam (CBT), Fructus Aurantii Immaturus (FAI), Pericarpium Citri Reticulatae (PCR), Poria (PA), and Radix Glycyrrhizae (RG), respectively ( Hou et al, 2021 ).…”