Effectiveness and tissue compatibility of a 12‐week treatment of chronic venous leg ulcers with an octenidine based antiseptic – a randomized, double‐blind controlled study

Abstract

The aim of this study was to evaluate the cytotoxic effect of octenidine dihydrochloride/phenoxyethanol (OHP) found in vitro by conducting a randomized, double-blind controlled clinical study focusing on its safe and effective use in chronic venous leg ulcers. In total, 126 male and female patients were treated with either OHP (n = 60) or Ringer solution (n = 66). The treatment lasted over a period of maximum 12 weeks. For the assessment of the wound-healing process, clinical outcome parameters were employed, that is, time span until 100% epithelization, wound status and the wound surface area were analysed. Side effects were recorded during the study period. The median time to complete ulcer healing was comparable between the OHP and Ringer solution groups (92 versus 87 days; P = 0·952), without being influenced by wound size or duration of the target ulcer (P-values: 0·947/0·978). In patients treated with OHP, fewer adverse events (AEs) were observed compared with the Ringer group (17% versus 29% of patients reported 20 versus 38 AEs). OHP is well suitable for the treatment of chronic wounds without cytotoxic effects. Furthermore, OHP does not impair the wound healing in chronic venous ulcers.

A comparison of the irritant and allergenic properties of antiseptics

“…The conclusion of the authors was that penetrating hand wounds must not be irrigated with Octenisept ® [19]. It has not been decided whether this side effect was associated (or not) to the combined presence of octenidine and phenoxyethanol but it has to be emphasized that it has never been related to phenoxyethanol when used alone [20]. Similarly, a long-lasting cutaneous side effect after inappropriate use of Octenisept ® solution has been described.…”

A prospective case series evaluating the safety and efficacy of the Klox BioPhotonic System in venous leg ulcers

“…The same search, as previously described, allowed us to retrieve nine publications reporting on time to wound closure (either mean or median) varying from 5 to 6 weeks up to 1 year. 32,36,40,53,[57][58][59][60][61] The BioPhotonic System performed well when compared with other treatments in terms of closure rates and time to wound closure. Furthermore, its treatment regimen led to a high rate of compliance.…”

Bacterial Growth Kinetics under a Novel Flexible Methacrylate Dressing Serving as a Drug Delivery Vehicle for Antiseptics

“…Apart from the specific, physical characteristics of different antimicrobial dressings, the most widely used agents in antimicrobial dressings are various forms of silver (ionic, elementary, nano-crystalline, or silver salts) [10], iodine [11], and increasingly medical honey. Some antimicrobial dressings contain PHMB [12,13], others chlorhexidine, and so far, no commercially available wound dressing contains the antiseptic octenidine-dihydrochloride (OCT) [14] yet. The available range of these different dressings in clinical practice means that large volumes of dressings need to be kept in stock.…”