Effectiveness and tolerability of Tonsilgon® N in the treatment of recurrent upper respiratory tract infections in children: a non-interventional study in Russia

Vavilova, Vera; Abramov-Sommariva, Dimitri; Steindl, Hubert; Wonnemann, Meinolf; Ryzhova, Elena G.; Русова, Т. В.; Лебеденко, А. А.; Kolchenko, Ivan I.

doi:10.1186/s40816-016-0020-9

Cited by 10 publications

(4 citation statements)

References 4 publications

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“…Moreover, the immunomodulatory effects of the medicine have been shown, and these refer to stimulation of nK cell activity by 150%, increased cytolytic activity and interferon production, as demonstrated in an in vitro study of human tonsil cells [19]. Clinical studies: Clinical studies have confirmed the therapeutic efficacy of the medicine in relieving the course of infection, as well as shortening its duration [23][24][25]. the controlled clinical trials conducted to date are not sufficient to support the well-established use of the medicinal product.…”

Section: Onion Bulb (Allii Cepae Bulbus)mentioning

confidence: 94%

Herbal medicinal products in RESPIRATORY diseases – STANce of the Polish PHYTOtherapy Association – STANPHYTO RESPIRATORY II

Doniec,

Krauze-Baranowska,

Czerwionka-Szaflarska

et al. 2023

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the paper reviews herbal medicinal products used in infectious diseases of the respiratory tract. Due to the multidirectional effects of the biological action of the contained herbal active substances (anti-inflammatory, antioxidant, antimicrobial, antitussive, diuretic and others), they have the properties that alleviate the severity of symptoms, reduce their frequency and, consequently, shorten the duration of the disease, as well as reduce the risk of complications. some of them have additional immunomodulatory properties, supporting natural immune mechanisms.

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Section: Onion Bulb (Allii Cepae Bulbus)mentioning

confidence: 94%

Herbal medicinal products in RESPIRATORY diseases – STANce of the Polish PHYTOtherapy Association – STANPHYTO RESPIRATORY II

Doniec,

Krauze-Baranowska,

Czerwionka-Szaflarska

et al. 2023

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“…Overall compliance was high (88.2%). This leads to the conclusion that BNO 1030/1035 is a safe and effective option for the treatment of acute respiratory viral infections in children (aged 2-11 years) which reduces the duration of ARVI symptoms [16].…”

Section: Sinupret® Extract: a History Of Success (Prof Claus Bachertmentioning

confidence: 99%

Review of the Phytoneering Research & Experience Summit (PRES) 2019 “building bridges between nature’s healing potential and evidence-based medicine - 20 years of phytoneering”

et al. 2020

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This brief communication summarizes the key highlights presented at the 2019 Phytoneering Research and Experience Summit held at the Palma Convention Centre and the educational finca Sa Canova (Majorca, Spain) from the 25th to the 27th of July 2019. More than 100 professionals from academia, industry and public services took part. The scientific programme included three dedicated symposium sessions and a moderated poster session. In total, 13 oral communications and 23 posters were presented. The invite-only conference, entitled: "Phytoneering Research & Experience Summit (PRES) 2019-Building bridges between nature's healing potential and evidence-based medicine-20 years of phytoneering", had participants from 20 different nations, reflecting the international character of the event. This participant group included researchers as well as clinicians with different fields of interest, e.g. gynaecology, urology, respiratory diseases and paediatrics. They all share an interest in evidence-based phytotherapy and phytoneering, which is the combination of ancient knowledge about medicinal plants and state-of-the-art technology to produce evidence-based herbal medicine. This approach offers solutions to reduce the growing number of unnecessarily prescribed antibiotics in the abovementioned areas, with the aim of preventing further progression of antibiotic resistance. The conference was sponsored by Bionorica® SE.

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“…Furthermore, cough can be targeted through specific antitussive medicines [10][11][12]. A number of herbal and traditional remedies also exist to help alleviate symptoms including honey as an antitussive agent [13], saline solutions for nasal congestion and throat irritation [14], vitamins, mineral supplements and remedies purported to boost immune function [12,[15][16][17] and topical vapour rub ointments containing menthol, camphor and eucalyptus, which release therapeutic vapours aimed at reducing cough and congestion and making breathing easier [18].…”

Section: Introductionmentioning

confidence: 99%

Modulation of transient receptor potential (TRP) channels by plant derived substances used in over-the-counter cough and cold remedies

2023

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Background Upper respiratory tract infections (URTIs) impact all age groups and have a significant economic and social burden on society, worldwide. Most URTIs are mild and self-limiting, but due to the wide range of possible causative agents, including Rhinovirus (hRV), Adenovirus, Respiratory Syncytial Virus (RSV), Coronavirus and Influenza, there is no single and effective treatment. Over-the-counter (OTC) remedies, including traditional medicines and those containing plant derived substances, help to alleviate symptoms including inflammation, pain, fever and cough. Purpose This systematic review focuses on the role of the major plant derived substances in several OTC remedies used to treat cold symptoms, with a particular focus on the transient receptor potential (TRP) channels involved in pain and cough. Methods Literature searches were done using Pubmed and Web of Science, with no date limitations, using the principles of the PRISMA statement. The search terms used were ‘TRP channel AND plant compound’, ‘cough AND plant compound’, ‘cough AND TRP channels AND plant compound’, ‘cough AND P2X3 AND plant compound’ and ‘P2X3 AND plant compound’ where plant compound represents menthol or camphor or eucalyptus or turpentine or thymol. Results The literature reviewed showed that menthol activates TRPM8 and may inhibit respiratory reflexes reducing irritation and cough. Menthol has a bimodal action on TRPA1, but inhibition may have an analgesic effect. Eucalyptus also activates TRPM8 and inhibits TRPA1 whilst down regulating P2X3, aiding in the reduction of cough, pain and airway irritation. Camphor inhibits TRPA1 and the activation of TRPM8 may add to the effects of menthol. Activation of TRPV1 by camphor, may also have an analgesic effect. Conclusions The literature suggests that these plant derived substances have multifaceted actions and can interact with the TRP ‘cough’ receptors. The plant derived substances used in cough and cold medicines have the potential to target multiple symptoms experienced during a cold.

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Effectiveness and tolerability of Tonsilgon® N in the treatment of recurrent upper respiratory tract infections in children: a non-interventional study in Russia

Cited by 10 publications

References 4 publications

Herbal medicinal products in RESPIRATORY diseases – STANce of the Polish PHYTOtherapy Association – STANPHYTO RESPIRATORY II

Herbal medicinal products in RESPIRATORY diseases – STANce of the Polish PHYTOtherapy Association – STANPHYTO RESPIRATORY II

Review of the Phytoneering Research & Experience Summit (PRES) 2019 “building bridges between nature’s healing potential and evidence-based medicine - 20 years of phytoneering”

Modulation of transient receptor potential (TRP) channels by plant derived substances used in over-the-counter cough and cold remedies

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