Effectiveness and Tolerance of Antituberculosis Treatment Regimens Without Isoniazid and Rifampicin: Analysis of 85 Cases

Tost, José R.; Vidal, Rafael; Maldonado, José; Caylà, Joan A.

doi:10.1016/s1579-2129(08)60086-5

Cited by 5 publications

(2 citation statements)

References 15 publications

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“…According to Tost et al, 15 a tuberculosis treatment regimen is useful when more than 95% of patients are cured and less than 5% develop severe intolerance. In our study, patients received IPT for 6 months, with a high treatment completion rate (> 90.0%) and a low treatment abandonment rate (0.99%).…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and treatment of latent tuberculosis infection in patients undergoing treatment with immunobiologic agents: a four-year experience in an endemic area

2019

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Objective: To describe the incidence of active tuberculosis and the occurrence of adverse events after isoniazid treatment in patients with latent tuberculosis infection (LTBI) who also had chronic inflammatory diseases and were treated with immunobiologic agents in an endemic area in Brazil. Methods: The diagnosis of LTBI was based on anamnesis, clinical examination, chest X-ray, and a tuberculin skin test (TST). Patients received prophylactic treatment (isoniazid for six months) in accordance with the Brazilian guidelines. Results: A total of 101 patients were evaluated between July of 2011 and July of 2015. Of those, 55 (54.46%) were women (mean age, 53.16 ± 1.76 years) and 46 (45.54%) were men (mean age, 45.39 ± 2.13 years). A total of 79 patients (78.22%) were being treated with immunobiologic agents and 22 (21.78%) were being treated with immunomodulatory or immunosuppressive agents. In the screening for LTBI, 53 patients (52.48%) had a TST induration ≥ 10 mm. Chest X-ray findings consistent with LTBI were observed in 36 patients (35.64%). Isoniazid preventive therapy was effective in 96 (95.05%) of the 101 patients evaluated. It is of note that 84 (83.17%) of the patients experienced no adverse effects from the use of isoniazid and that 83 (98.81%) of those patients completed the prophylactic treatment (p = 0.002). Active tuberculosis was diagnosed in 5 (6.33%) of the 79 patients treated with immunobiologic agents and in 1 (4.55%) of the 22 patients treated with other immunomodulators/immunosuppressants. Conclusions: A six-month course of isoniazid proved to be safe and effective in the treatment of LTBI, which is essential to reducing the risk of developing active tuberculosis.

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Section: Discussionmentioning

confidence: 99%

Diagnosis and treatment of latent tuberculosis infection in patients undergoing treatment with immunobiologic agents: a four-year experience in an endemic area

2019

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“…Patients who underwent both debridement and arthrodesis were assessed using a visual analogue scale (VAS) 12 and the Oswestry Disability Index (ODI) 12 Mild-to-moderate hepatotoxicity was defined as any transaminase elevation of less than 10-fold the normal value, or any elevation of cholestasis parameters of less than three-fold the normal value. 13 Signs of resistance to drug therapy were monitored by assessing the activity of TBS during chemotherapy. If the disease was not controlled within 4 -5 months, or if more active tuberculous lesions appeared, which indicated that disease activity was not subsiding, multidrug resistance was suspected.…”

Section: Outcomes Assessmentmentioning

confidence: 99%

Tuberculous Sacroiliitis: A Study of the Diagnosis, Therapy and Medium-Term Results of 15 Cases

Gao

et al. 2011

J Int Med Res

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This report reviews the diagnosis, treatment and follow-up of 15 Chinese patients with tuberculous sacroiliitis (TBS) from 1997 to 2007. Buttock pain and lower back pain were the main complaints. All patients received antituberculosis chemotherapy treatment for at least 18 months; 10 also underwent surgery, with seven undergoing modified Smith-Petersen arthrodesis (evaluated using a visual analogue scale [VAS] for pain and the Oswestry Disability Index [ODI]). No simplex tuberculous synovitis existed at diagnosis. Bone-marrow oedema, cold abscess and soft-tissue oedema responded to antituberculosis treatment. Thirteen patients (86.7%) had satisfactory outcomes. There were also significant improvements in VAS and ODI scores post-operatively. In the chemotherapy plus surgery group, eight patients had solid bony fusions at 24 months post-operatively, while the five on chemotherapy alone presented with fibrous ankylosis at 24 months. Chemotherapy is the main treatment for TBS and modified arthrodesis is a feasible and effective method for treating severe joint destruction.

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Investigación en infecciones respiratorias: una perspectiva desde el Área Tuberculosis e Infecciones Respiratorias (TIR)

Cremades¹,

Souza-Galvão²,

García³

et al. 2009

Archivos de Bronconeumología

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Effectiveness and Tolerance of Antituberculosis Treatment Regimens Without Isoniazid and Rifampicin: Analysis of 85 Cases

Cited by 5 publications

References 15 publications

Diagnosis and treatment of latent tuberculosis infection in patients undergoing treatment with immunobiologic agents: a four-year experience in an endemic area

Diagnosis and treatment of latent tuberculosis infection in patients undergoing treatment with immunobiologic agents: a four-year experience in an endemic area

Tuberculous Sacroiliitis: A Study of the Diagnosis, Therapy and Medium-Term Results of 15 Cases

Investigación en infecciones respiratorias: una perspectiva desde el Área Tuberculosis e Infecciones Respiratorias (TIR)

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