Effectiveness and toxicity of helical tomotherapy for patients with locally recurrent nasopharyngeal carcinoma

Abstract

Reirradiation with HT in patients with LRNPC is feasible and yields encouraging results in terms of local control and overall survival with acceptable toxicity.

Long‐term outcomes after reirradiation in nasopharyngeal carcinoma with intensity‐modulated radiotherapy: A meta‐analysis

“…Of the 55 studies for which full texts were reviewed, 43 were excluded as they were irrelevant or did not meet the inclusion criteria (see Figure ). We identified 12 studies, including 1768 patients (Table ) . Of the studies included, 11 were from China and 1 was from Spain.…”

“…We identified 12 studies, including 1768 patients (Table 1). [18][19][20][21][22][23][24][25][26][27][28][29] Of the studies included, 11 were from China and 1 was from Spain. Two studies were RCTs, 1 was a retrospective cohort study, 1 was a case control study, and the remaining 8 were single-institutional retrospective case series.…”

“…The methodological quality of the included studies is summarized in Table 2. [18][19][20][21][22][23][24][25][26][27][28][29] Four studies were judged to have a low to moderate risk of bias, 22,24,27,29 and 8 studies were deemed to have a moderate to high risk of bias. [18][19][20][21]23,25,26,28…”

“…45 A small nonrandomized study that compared hyperfractionated and standard fractionation IMRT in recurrent NPC showed a trend in favor of the former with regard to local control and reduction of treatment-related hemorrhage. 46 We were unable to evaluate the effects of hyperfractionation because the studies included in our meta-analysis either did not utilize it, [19][20][21][22][23][24][25][26]28,29 or did not report on the fractionation schedule. 18,27 The value of hyperfractionated IMRT in recurrent NPC should be evaluated in a prospective randomized trial.…”

Short-term efficacy comparison between helical tomotherapy and intensity-modulated radiotherapy in patients with locally advanced nasopharyngeal carcinoma

“…Effective improvement of the CI and HI of the target area could reduce radiotherapy related side effects, thereby improving the quality of life of patients after radiotherapy is the major concern in the treatment of nasopharyngeal carcinoma in current clinical practice. Puebla [11] conducted a study of 17 patients with locally advanced nasopharyngeal carcinoma who underwent HT radiotherapy and the results showed that HT had better target area CI and HI than conventional IMRT in dosimetry, which could result in signi cantly decreased dose exposure on the vital organs. Zhang et al [12] compared the Three-dimensional Conformal Radiotherapy (3D-CRT) plan with the HT plan dosimetry for patients with locally advanced nasopharyngeal carcinoma, and the results showed that the use of spiral tomography in HT can further improve the CI and HI of the target area, thereby achieving a better protection of normal tissue.…”