Effectiveness assessment of repetitive transcranial alternating current stimulation with concurrent EEG and fNIRS measurement

Yang, Dalin; Ghafoor, Usman; Eggebrecht, Adam T.; Hong, Keum–Shik

doi:10.1007/s13755-023-00233-y

Cited by 5 publications

(4 citation statements)

References 87 publications

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“…The sparse design of the fNIRS array presents challenges in establishing short separation channels for measuring extracerebral signals. Additionally, future work on systematic manipulation is required to determine the best stimulation protocol (i.e., stimulation intensity and frequency) and to enhance brain excitation [17], [76], [77].…”

Section: Discussionmentioning

confidence: 99%

Repetitive Transcranial Alternating Current Stimulation to Improve Working Memory: An EEG-fNIRS Study

Yang,

Kang,

Huang

et al. 2024

IEEE Trans. Neural Syst. Rehabil. Eng.

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Transcranial electrical stimulation has demonstrated the potential to enhance cognitive functions such as working memory, learning capacity, and attentional allocation. Recently, it was shown that periodic stimulation within a specific duration could augment the human brain's neuroplasticity. This study investigates the effects of repetitive transcranial alternating current stimulation (tACS; 1 mA, 5 Hz, 2 min duration) on cognitive function, functional connectivity, and topographic changes using both electroencephalography (EEG) and functional nearinfrared spectroscopy (fNIRS). Fifteen healthy subjects were recruited to measure brain activity in the pre-, during-, and post-stimulation sessions under tACS and sham stimulation conditions. Fourteen trials of working memory tasks and eight repetitions of tACS/sham stimulation with a 1-minute intersession interval were applied to the frontal cortex of the participants. The working memory score, EEG band-wise powers, EEG topography, concentration changes of oxygenated hemoglobin, and functional connectivity (FC) were individually analyzed to quantify the behavioral and neurophysiological effects of tACS. Our results indicate that tACS increases: i) behavioral scores (i.e., 15.08, p <0.001) and EEG band-wise powers (i.e., theta and beta bands) compared to the sham stimulation condition, ii) FC of both EEG-fNIRS signals, especially in the large-scale brain network communication and interhemispheric connections, and iii) the hemodynamic Manuscript

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Section: Discussionmentioning

confidence: 99%

Repetitive Transcranial Alternating Current Stimulation to Improve Working Memory: An EEG-fNIRS Study

Yang,

Kang,

Huang

et al. 2024

IEEE Trans. Neural Syst. Rehabil. Eng.

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“…Cognitive function is severely impaired when reaching severe PSCI, and the diagnostic criteria for dementia have been met. Patients may experience severe memory loss, language impairment, and behavioral abnormalities ( 11 – 14 ). Multiple studies have consistently demonstrated that individuals diagnosed with PSCI exhibit poorer rehabilitation outcomes related to physical function.…”

Section: Introductionmentioning

confidence: 99%

EEG biomarkers analysis in different cognitive impairment after stroke: an exploration study

Xu,

Zhang,

Zhang

et al. 2024

Front. Neurol.

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Stroke is a cerebrovascular illness that brings about the demise of brain tissue. It is the third most prevalent cause of mortality worldwide and a significant contributor to physical impairment. Generally, stroke is triggered by blood clots obstructing the brain’s blood vessels, or when these vessels rupture. And, the cognitive impairment’s evaluation and detection after stroke is crucial research issue and significant project. Thus, the objective of this work is to explore an potential neuroimage tool and find their EEG biomarkers to evaluate and detect four cognitive impairment levels after stroke. In this study, power density spectrum (PSD), functional connectivity map, and one-way ANOVA methods were proposed to analyze the EEG biomarker differences, and the number of patient participants were thirty-two human including eight healthy control, mild, moderate, severe cognitive impairment levels, respectively. Finally, healthy control has significant PSD differences compared to mid, moderate and server cognitive impairment groups. And, the theta and alpha bands of severe cognitive impairment groups have presented consistent superior PSD power at the right frontal cortex, and the theta and beta bands of mild, moderated cognitive impairment (MoCI) groups have shown significant similar superior PSD power tendency at the parietal cortex. The significant gamma PSD power difference has presented at the left-frontal cortex in the mild cognitive impairment (MCI) groups, and severe cognitive impairment (SeCI) group has shown the significant PSD power at the gamma band of parietal cortex. At the point of functional connectivity map, the SeCI group appears to have stronger functional connectivity compared to the other groups. In conclusion, EEG biomarkers can be applied to classify different cognitive impairment groups after stroke. These findings provide a new approach for early detection and diagnosis of cognitive impairment after stroke and also for the development of new treatment options.

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“…The largest number of tACS studies (e.g., Jaušovec and Jaušovec, 2014 ; Jaušovec et al, 2014 ; Meiron and Lavidor, 2014 ; Vosskuhl et al, 2015 ; Alekseichuk et al, 2016 , 2017 ; Feurra et al, 2016 ; Santarnecchi et al, 2016 ; Kleinert et al, 2017 ; Borghini et al, 2018 ; Pahor and Jaušovec, 2018 ; Röhner et al, 2018 ; Tseng et al, 2018 ; Wolinski et al, 2018 ; Bender et al, 2019 ; Jones et al, 2019 ; Reinhart and Nguyen, 2019 ; Abellaneda-Pérez et al, 2020 ; Guo et al, 2021 ; Hosseinian et al, 2021 ; Sahu and Tseng, 2021 ; Biel et al, 2022 ; Draaisma et al, 2022 ; Hu et al, 2022 ; Soutschek et al, 2022 ; Zeng et al, 2022 ; Zhang et al, 2022 ; Grover et al, 2023 ; Rauh et al, 2023 ; Yang et al, 2023 ) targeted the theta band (4 Hz−7 Hz), which was proposed as the brain rhythm most strongly involved in encoding and maintaining the item sequences in WM (e.g., Lisman and Idiart, 1995 ; Jacob et al, 2018 ; Sauseng et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

“…However, other studies yielded null or at best mixed results regarding the theta-frequency tACS for the n-back (Pahor and Jaušovec, 2018 ; Röhner et al, 2018 ; Jones et al, 2019 ; Soutschek et al, 2022 ; Zeng et al, 2022 ; Yang et al, 2023 ) and change-detection task (Santarnecchi et al, 2016 ; Alekseichuk et al, 2017 ; Kleinert et al, 2017 ; Pahor and Jaušovec, 2018 ; Tseng et al, 2018 ; Zhang et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

No effects of the theta-frequency transcranial electrical stimulation for recall, attention control, and relation integration in working memory

Ociepka,

Chinta,

Basoń

et al. 2024

Front. Hum. Neurosci.

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IntroductionRecent studies have suggested that transcranial alternating current stimulation (tACS), and especially the theta-frequency tACS, can improve human performance on working memory tasks. However, evidence to date is mixed. Moreover, the two WM tasks applied most frequently, namely the n-back and change-detection tasks, might not constitute canonical measures of WM capacity.MethodIn a relatively large sample of young healthy participants (N = 62), we administered a more canonical WM task that required stimuli recall, as well as we applied two WM tasks tapping into other key WM functions: attention control (the antisaccade task) and relational integration (the graph mapping task). The participants performed these three tasks three times: during the left frontal 5.5-Hz and the left parietal 5.5-Hz tACS session as well as during the sham session, with a random order of sessions. Attentional vigilance and subjective experience were monitored.ResultsFor each task administered, we observed significant gains in accuracy neither for the frontal tACS session nor for the parietal tACS session, as compared to the sham session. By contrast, the scores on each task positively inter-correlated across the three sessions.DiscussionThe results suggest that canonical measures of WM capacity are strongly stable in time and hardly affected by theta-frequency tACS. Either the tACS effects observed in the n-back and change detection tasks do not generalize onto other WM tasks, or the tACS method has limited effectiveness with regard to WM, and might require further methodological advancements.

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Effectiveness assessment of repetitive transcranial alternating current stimulation with concurrent EEG and fNIRS measurement

Cited by 5 publications

References 87 publications

Repetitive Transcranial Alternating Current Stimulation to Improve Working Memory: An EEG-fNIRS Study

Repetitive Transcranial Alternating Current Stimulation to Improve Working Memory: An EEG-fNIRS Study

EEG biomarkers analysis in different cognitive impairment after stroke: an exploration study

No effects of the theta-frequency transcranial electrical stimulation for recall, attention control, and relation integration in working memory

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