Effectiveness comparisons of different Chinese herbal injection therapies for acute cerebral infarction

Abstract

Background: Acute cerebral infarction (ACI) has a high incidence, recurrence rate, and mortality. Chinese herbal injections (CHIs) are widely used in the substitution therapy of ACI. Due to the lack of randomized trials comparing the efficacy of various injections directly, it is still difficult to judge the relative efficacy. Therefore, we intend to conduct a network meta-analysis to evaluate the benefit among these CHIs. Methods: According to the retrieval strategies, randomized controlled trials (RCTs) on CHI therapies for ACI will be obtained from China National Knowledge Infrastructure, WanFang, Chinese Scientific Journals Database, PubMed, Embase and Cochrane Library, regardless of publication date or language. Studies were screened based on inclusion and exclusion criteria, and the Cochrane risk bias assessment tool will be used to evaluate the quality of the literature. The network meta-analysis will be performed in Markov Chain Monte Carlo method and carried out with Stata 14 and WinBUGS 1.4.3 software. Ultimately, the evidentiary grade for the results will be evaluated. Results: This study will compare the efficacy and safety of CHIs in the treatment of ACI, and give a more reasonable choice. Conclusion: Our findings will provide references for future clinical decision and guidance developing. INPLASY registration number: INPLASY202060087.

Safflower yellow pigment and Sanqi Panax notoginseng in the treatment of acute cerebral infarction: a systematic review, meta-analysis, and cost-effectiveness analysis

“…After evaluating, all studies achieved a score no less than 3, which indicating that all studies had good methodological quality. The summarized content for each study (13,(20)(21)(22)(23)(24)(25)(26)(27)(28)(29) is shown in Table 1.…”

“…The 12 studies (13,(20)(21)(22)(23)(24)(25)(26)(27)(28)(29) that reported the effective rate were analyzed under a random effect model. Meta-analysis showed a significantly higher overall effective rate in safflower yellow group compared with that in the control group (RR =1.24, 95% CI: 1.19, 1.30, P<0.00001) (Figure 2) (30).…”

“…According to the results of the previous meta-analysis, heterogeneity exists among some studies (13,(20)(21)(22)(23)(24)(25)(26)(27)(28)(29) of safflower yellow in the treatment of cerebral infarction.…”

“…Seven studies that reported the effective rate (21,22,(24)(25)(26)(27)(28) were analyzed under a fixed effect model. Meta-analysis showed a significantly higher effective rate in safflower yellow group compared with that in control group (OR =4.33, 95% CI: 2.67, 7.05, P<0.00001) (Figure 3).…”

“…The funnel plot of the total effective rate evaluated in the included papers (13,(20)(21)(22)(23)(24)(25)(26)(27)(28)(29) was analyzed (Figure 5). The funnel plot was essentially symmetric, suggesting absence of publication bias (Egger P=0.223; Begger P=0.2441).…”