Effectiveness complex treatment of isolated optic disk vasculitis

Abstract

Purpose. To study effectiveness combination of topical corticosteroid therapy and sulodexide in complex treatment of patients with isolated optic disk vasculitis (IODV). Material and methods. The study included 17 patients with IODV (middle age was 26.7±6.2 years on average). Depending on different of additions to topical corticosteroid therapy, the patients were divided into two groups: the main group (8 people), treatment regimen of which additionally included sulodexide during and after the end of inpatient treatment, and the control group (9 people), which at inpatient treatment sulodexide was not prescribed, and then picamilon was prescribed. The results of treatment were assessed according to the measured of best corrected visual acuity (BCVA), static perimetry with determination total number of scotomas (TNS) in the central visual field, and the central retinal thickness (CRT) was examined. Morphometric indicators of intact eyes were taken as variant of the norm. Based on the data of ophthalmoscopy and biomicroscopy, the total clinical index of inflammation (TCII) was calculated. All studies were performed upon admission of patients to inpatient treatment and after its completion, and then after 1, 3 and 6 months. Results. As result of study, an increased efficacy of pharmacotherapy in patients with IODV was established when sulodexide is included in the complex treatment. We noted: reduction times of disappearance of TCII by 1.6 times; increase of BCVA by 3 times after 6 months; disappearance of TNS in the central visual field is 2 times faster; restoration of CRT to normal values by 3 times faster. Conclusion. Comparative analysis of clinical efficacy of complex treatment of IODV, including topical corticosteroid therapy and sulodexide, allows us to recommend it for use in clinical practice. Key words: isolated optic disk vasculitis, corticosteroid therapy, sulodexide.