Effectiveness Evaluation of Levamisole, Albendazole, Ivermectin, and<i>Vernonia amygdalina</i>in West African Dwarf Goats

Adediran, Oyeduntan Adejoju; Uwalaka, Emmanuel Chibuike

doi:10.1155/2015/706824

Cited by 30 publications

(28 citation statements)

References 22 publications

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“…In contrast, the former registered a relatively higher anti-schistosomal index in vivo. Interestingly, V. amygdalina exerted a better adulticidal activity than the standard drug praziquantel in vivo, similar to results reported by Adediran and Uwalaka [25]. Their study proves that V. amygdalina is relatively more potent against helminths than conventional drugs ivermectin, levamisole and albendazole, attesting to its efficacy.…”

Section: Discussionsupporting

confidence: 86%

“…Their study proves that V. amygdalina is relatively more potent against helminths than conventional drugs ivermectin, levamisole and albendazole, attesting to its efficacy. Additionally, a study by Ogboli et al [26] also reports that the leaf extracts of V. amygdalina have curative effects on mice infected with Schistosoma mansoni [25][26][27][28]. Undoubtedly, V. amygdalina demonstrates that it possesses anti-schistosomal activity and should, therefore, be investigated further to derive the full benefit.…”

Section: Discussionmentioning

confidence: 99%

“…The mice were fed on standard pellet diet (Grower Mash, Essaar, Ghana) and provided water ad libitum. Twenty-five (25) of the mice were infected percutaneously as follows. Each mouse was placed in a glass restrainer and its tail then placed in an approximately n = 150 S. mansoni cercariae suspension for 60 min.…”

Section: Maintenance and Infection Of Mice With Cercariaementioning

confidence: 99%

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Ethnopharmacological evaluation of schistosomicidal and cercaricidal activities of some selected medicinal plants from Ghana

et al. 2020

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Background: The adulticidal and cercaricidal activities of five Ghanaian medicinal plants, namely, Phyllanthus amarus, Vernonia amygdalina, Azadirachta indica, Morinda lucida and Nauclea latifolia against S. mansoni were evaluated in this study. Six weeks old ICR mice (n = 25) were percutaneously infected with S. mansoni cercariae. Nine weeks later, infected mice (n = 5) were anaesthetised and perfused for adult S. mansoni. Cercariae were treated with different concentrations (1000, 500, 250, 125, 62.5, 31.25 μg/mL) of methanolic extracts of the experimenting plants in triplicates. Adult S. mansoni incopula were also treated with same concentrations of each extract or 20 μg/mL praziquantel. The cercariae and adult worms were observed at time intervals for 180 min and 120 h to assess mortality and viability respectively. Additionally, 9-week cercariae-infected mice (4 groups of 5 mice) were treated with either 500 mg/kg po A. indica or V. amygdalina, 400 mg/kg po praziquantel or distilled water for 14 days. The mice were euthanized after adult worms were recovered from them. The liver was processed and histologically examined for granuloma formations. Results: All the plants exhibited varying cercaricidal and adulticidal activities against S. mansoni in a time and concentration-dependent manner. A. indica (3 h IC 50 = 27.62 μg/mL) and V. amygdalina (3 h IC 50 = 35.84 μg/mL) exerted the highest cercaricidal activity. Worm recovery after treatment with V. amygdalina, A. indica and praziquantel in vivo was 48.8%, 85.1 % and 59.9 % respectively (p < 0.05). A. indica and V. amydalina-treated mice recorded lesser mean liver and spleen weights compared to untreated groups (p < 0.05). Conclusion:A. indica demonstrated the highest cercaricidal and alduticidal activities in vitro, whereas V. amygdalina exhibited the most potent aldulticidal activity in vivo. This study could provide baseline information which can be used to develop plant-based alternative commercial drugs against S. mansoni.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Maintenance and Infection Of Mice With Cercariaementioning

confidence: 99%

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Ethnopharmacological evaluation of schistosomicidal and cercaricidal activities of some selected medicinal plants from Ghana

et al. 2020

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“…The results of V. amygdalina in this study support the trials by the traditional healers that these plants treat helminth infections in livestock [17]. The good anthhelmintic potential of V. amygdalina observed in this research is supported by the report of Adediran and Uwalaka [18] that the plant had 100% faecal egg count reduction effect against goat's helminth parasites. However, the report of Nalule et al [17], and Innocent and Deogracious [16] is far from the findings of this study which states that this plant reveals only 64% faecal egg reduction count against mixed infection of goat's worm and kills 50% of the parasite at 6mg/ml respectively.…”

Section: Discussionsupporting

confidence: 85%

In vitro egg hatchability inhibition effect of Albizia gummifera, Phytolacca dodecandra, and Vernonia amygdalina against natural infection of ovine GIT nematodes

Tsehayneh

Melaku

2019

J Med Bot

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An in-vitro experiment was carried out to evaluate the egg hatching inhibition effect of three herbal plants, namely;Albizia gummifera, Phytolacca dodecandra, and Vernonia amygdalina. The leaves of these plants were collected; air dried and powdered with pestle and mortar, and then hydro-alcoholic extraction was performed and in measuring the percentage yield, P. dodecandra givesbetter yield (15.34%). Crude extract of these plants were evaluated for egg hatchability assay at different concentrations (3mg/ml, 5mg/ml and 10mg/ml) for each plant and the experiment was replicated five times. Ivermectin (0.1ml/ml) was used as positive control. Among the plants, the crude extracts of P. dodecandrahad better activity that achieved maximum (100%) egg hatch inhibition at concentrations of 5 mg/ml while V. amygdalina and A. gummifera induced complete inhibition at concentration of 10 mg/ml after 48 hours of exposure. All the three plant crude extracts were inhibit egg hatchability significantly (p< 0.05) as compared with the negative control but the inhibition among them were not significantly different in the effect. In conclusion, this study revealed that all of the three plant extracts have high inhibition potential on the hatchability of gastrointestinal nematode eggs. More detailed study on vivo anthelmintic effects of these plants with different extraction methods and phytochemical screening should be done.

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“…Second, the study was aimed at developing an alternative bioremediation method to increase the efficiency of manure stabilization by the addition of PM-containing CaO 2 . The degradation of pharmaceuticals have been responsible for the generation of many transformation products (TP) (Boxall et al 2003;Sadeghi et al 2007;Capece et al 2009;Prasad et al 2010;Horvat et al 2012;Oyeduntan and Uwalaka 2015;Technical Evaluation Report 2015;Mutavdžić Pavlović et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Peroxide impact on the fate of veterinary drugs in fertilizers

et al. 2019

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The presence of veterinary medicines in organic manure causes soil contamination which contributes to increasing resistance of indigenous microflora to drugs and results in greater susceptibility of people to allergies. The main aim of the study was to assess the efficiency of inorganic peroxide mixtures (PM) with calcium peroxide content (CaO 2) in the stabilization process of manure contaminated with antiparasitic agents: albendazole (ALB) and levamisole (LEV). As a solid, CaO 2 is relatively stable against decomposition. In contact with water, however, it hydrolyzes with release of oxygen. The hydrolyzation of CaO 2 proceeds very slowly in soil, which guarantees the constant release of hydrogen peroxide that subsequently becomes the source of free radicals (chemical oxidation) and oxygen (aerobic conditions for the microbes). It may contribute to continuous elimination of drugs from manure. The study has demonstrated that there were significant differences in ALB and LEV conversion stimulated by the PM addition. PM supplementation increased the drug availability (on average 15% and 25% increase in the initial concentration for ALB and for LEV, respectively), thereby increasing the initial rate of reaction. Elimination of ALB and LEV from the manure sorption complex is followed by Ca 2+ saturation. The initial degradation rate was affected by PM for both drugs, but the mechanisms of decomposition have been modified only for ALB. The loss of ALB in the peroxide supplemented samples was 92%, and in the samples, without the PM, it did not exceed 61%. Loss of LEV was over 90% irrespective of PM supplementation.

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Effectiveness Evaluation of Levamisole, Albendazole, Ivermectin, andVernonia amygdalinain West African Dwarf Goats

Cited by 30 publications

References 22 publications

Ethnopharmacological evaluation of schistosomicidal and cercaricidal activities of some selected medicinal plants from Ghana

Ethnopharmacological evaluation of schistosomicidal and cercaricidal activities of some selected medicinal plants from Ghana

In vitro egg hatchability inhibition effect of Albizia gummifera, Phytolacca dodecandra, and Vernonia amygdalina against natural infection of ovine GIT nematodes

Peroxide impact on the fate of veterinary drugs in fertilizers

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