Effectiveness of 7-Day and 14-Day Moxifloxacin-Dexlansoprazole Based Triple Therapy and Probiotic Supplement for Helicobacter Pylori Eradication in Thai Patients with Non-Ulcer Dyspepsia: A Double-Blind Randomized Placebo-Controlled Study

Chotivitayatarakorn, Peranart; Siramolpiwat, Sith; Chonprasertsuk, Soonthorn; Kanokwanvimol, Amornnivit; Tangaroonsanti, Anupong; Bhanthumkomol, Patommatat; Pornthisarn, Bubpha; Mahachai, Varocha; Vilaichone, Ratha-Korn

doi:10.1016/s0016-5085(17)31129-0

Cited by 17 publications

(24 citation statements)

References 12 publications

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“…Of these articles, 39 studies were further excluded based on the selection criteria (characteristics of the excluded studies and ongoing trials are presented in Table ). Finally, 18 RCTs(21 intervention arms) met the selection criteria for the meta‐analysis. The PRISMA flowchart of study selection process is presented in Figure .…”

Section: Resultsmentioning

confidence: 99%

“…Among these, three of which were published as conference abstracts . Six of these studies originated from China, four studies from Korea, two from Turkey, one from Italy, one from Romania, one from Greece, one from Iran, one from Thailand, and one from Morocco . Fourteen studies were published in English, and the remaining four studies in Chinese .…”

Section: Resultsmentioning

confidence: 99%

“…Except for three trials only involving children, all remaining trials enrolled adults. Three trials included multiple arms, with a total of 21 intervention arms. With regard to H pylori eradication regimen, fifteen trials used standard triple therapy, two used bismuth‐quadruple therapy, and one used sequential therapy .…”

Section: Resultsmentioning

confidence: 99%

“…In view of the high resistance of clarithromycin, however, only one trial was conducted in patients who were not resistant to clarithromycin. One trial performed antibiotic susceptibility tests, CYP2C19 and CagA genotyping simultaneously. Three trials were placebo‐controlled.…”

Section: Resultsmentioning

confidence: 99%

“…One trial performed antibiotic susceptibility tests, CYP2C19 and CagA genotyping simultaneously. Three trials were placebo‐controlled. Regarding S boulardii formulations, with the exception of four trials that did not explicitly provide drug form, the remaining probiotics were capsules or sachets.…”

Section: Resultsmentioning

confidence: 99%

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Saccharomyces boulardii as an adjuvant therapy for Helicobacter pylori eradication: A systematic review and meta‐analysis with trial sequential analysis

Zhou

Chen

et al. 2019

Helicobacter

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Background and Aims: Whether Saccharomyces boulardii (S boulardii) as an adjuvant therapy are beneficial to H pylori eradication remains controversial. The aim of the study was to update and determine the effects of S boulardii as an adjuvant therapy on H pylori eradication rates and adverse effects. Methods: We searched PubMed, Embase, CENTRAL, and Web of Science to collect all randomized controlled trials assessing the effects of S boulardii as an adjuvant therapy for H pylori eradication from inception to February 2019. Quality of evidence was appraised using Grading of Recommendations, Assessment, Development and Evaluation system. Trial sequential analysis was performed to control the risk of type I and type II errors.Results: Eighteen trials with 3592 patients were eligible for meta-analysis. Compared with standard eradication regimen, the S boulardii supplementation could significantly improve eradication rates [risk ratio (RR) = 1.09, 95% confidence interval (CI):1.05-1.13; moderate quality evidence] and reduce the incidence of total side effects (RR = 0.47, 95%CI:0.36-0.61; low quality evidence), as well as some gastrointestinal adverse effects, especially diarrhea (RR = 0.33, 95%CI:0.23-0.47; low quality evidence) and constipation (RR = 0.37, 95%CI:0.23-0.57; moderate quality evidence).In addition, the need for discontinuation rate in S boulardii supplementation group was significantly lower than in the control group (RR = 0.33, 95%CI:0.16-0.69, P = .003; moderate quality evidence). The TSA results for overall eradication rates and total side effects indicated that the effects were conclusive. Conclusions:Our meta-analysis shows that S boulardii supplementation on standard eradication therapy significantly increased H pylori eradication rates and reduced the incidence of total side effects and some gastrointestinal adverse effects during eradication therapy. K E Y W O R D SHelicobacter pylori, meta-analysis, Saccharomyces boulardii, trial sequential analysis 2 of 16 | ZHOU et al.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Saccharomyces boulardii as an adjuvant therapy for Helicobacter pylori eradication: A systematic review and meta‐analysis with trial sequential analysis

Zhou

Chen

et al. 2019

Helicobacter

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The impacts of probiotics in eradication therapy of Helicobacter pylori

Bai

Zhu

et al. 2022

Arch Microbiol

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Helicobacter pylori (H. pylori) is a well-known pathogen that infects approximately half of the world’s population. It is a pathogenic agent with potential health hazards related to diverse diseases, especially digestive diseases, such as chronic gastritis, peptic ulcer, and gastric carcinoma. In clinical, antibiotics are commonly applied in eradication therapy of H. pylori. However, the increase in antibiotic resistance and side effects has induced the failure of eradication therapy. Recent studies have shown that probiotic supplementation has promising application prospects. It can restore the gastrointestinal microbiota balance and prevent dysbacteriosis caused by antibiotics. Furthermore, it has been reported to have direct or indirect inhibitory effects on H. pylori. Probiotics may have a beneficial effect on H. pylori eradication. However, the strain, dosages, duration times, and safety of probiotic supplementation need further study before clinical applications.

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Rescue effects of Lactobacillus-containing bismuth regimens after Helicobacter pylori treatment failure

Keikha

2021

New Microbes and New Infections

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At present, it has been scientifically proven that Helicobacter pylori is associated with gastrointestinal and extra-gastrointestinal diseases. Based to many studies, probiotics such as Lactobacillus , Bifidobacterium , and Saccharomyces , potentially are enable to reduce the severe clinical outcomes of gastrointestinal infections of this bacterium. Accordingly, the efficacy of Lactobacillus -containing bismuth quadruple therapy was measured by odds ratio with 95% confidence intervals. Overall, our statistical analysis results showed that Lactobacillus -containing bismuth quadruple therapy as rescue regimen, could have grater therapeutic effects during the treatment and eradication of Helicobacter pylori infection than non-probiotic treatment regimens in cases of treatment failure.

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Effectiveness of 7-Day and 14-Day Moxifloxacin-Dexlansoprazole Based Triple Therapy and Probiotic Supplement for Helicobacter Pylori Eradication in Thai Patients with Non-Ulcer Dyspepsia: A Double-Blind Randomized Placebo-Controlled Study

Cited by 17 publications

References 12 publications

Saccharomyces boulardii as an adjuvant therapy for Helicobacter pylori eradication: A systematic review and meta‐analysis with trial sequential analysis

Saccharomyces boulardii as an adjuvant therapy for Helicobacter pylori eradication: A systematic review and meta‐analysis with trial sequential analysis

The impacts of probiotics in eradication therapy of Helicobacter pylori

Rescue effects of Lactobacillus-containing bismuth regimens after Helicobacter pylori treatment failure

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