Effectiveness of a bone substitute (CERAMENT™) as an alternative to PMMA in percutaneous vertebroplasty: 1-year follow-up on clinical outcome

Abstract

Data show that CERAMENT can be a substitute of PMMA in the treatment of osteoporotic and traumatic vertebral fractures, especially in young patients.

The composite of hydroxyapatite and calcium sulphate: a review of preclinical evaluation and clinical applications

“…The composite of HA and calcium sulfate has been used clinically with good results in various indications [58][59][60][61][62][63][64][65][66][67], which is further explained below.…”

“…Marcia et al reported no new fractures studying vertebroplasty treatment with HA/calcium sulfate in 33 patients during 1 year [62]. Siemund et al concluded that the biphasic material was safe and effective in the treatment of acute osteoporotic vertebral body fractures and Marcia et al stressed the advantage to use this material in young patients due to its bone healing ability [62,64].…”

“…There are five studies published on the use of HA/calcium sulfate material (Cerament) in vertebroplasty [61][62][63][64]67], with totally 115 patients enrolled and with a minimum follow-up time of 1 year. The aim of treating vertebral compression fractures with a biological material was to achieve bone healing and implant material resorption without compromising the good pain relief given by poly(methyl methacrylate) (PMMA) in this application [69][70][71].…”

Percutaneous stabilization of lumbar spine: a literature review and new options in treating spine pain

“…[45][46][47][48][49] Recent studies showed that few new-generation bioactive bone cements have been found to induce new bone formation and also have good mechanical stability. 50,51 Bioactive composite materials prepared from acrylic cement in conjunction with ceramics showed good radioopacity. 52 Cortoss, a composed material-based bone cement currently undergoing clinical trials for PVP and BKP is composed of terpolymer resin with combeite glass-ceramics.…”

Percutaneous vertebroplasty: a new animal model

“…Its higher radiopacity enabled visualization of the 6 cement whilst injecting (figure 11) [21]. However, iohexol generates artefacts in the microCT images that 7 prevent a correct evaluation of the cement inside the bone defect, impairing the evaluation of injected 8 cement volume and the determination of possible leakage (figure 12).…”