“…Twelve trials [ 5 , 38 , 39 , 41 , 42 , 44 , 45 , 46 , 47 , 48 , 49 , 52 ] were randomised controlled trials (RCTs), three were cluster RCTs [ 40 , 50 , 51 ], and one was a non-randomised controlled trial [ 43 ]. Most trials were conducted in the USA [ 5 , 40 , 42 , 43 , 44 , 45 , 47 , 48 , 49 , 51 ], with the remaining trials in China [ 38 , 39 , 41 , 52 ], Germany [ 46 ], and Spain [ 50 ]. Six trials were conducted exclusively in neonates [ 5 , 43 , 44 , 46 , 51 , 52 ], two in young infants (0–18 months) [ 41 , 50 ], five in children aged up to 5 years [ 38 , 39 , 42 , 47 , 48 ], and three in children aged up to 12 years [ 40 , 45 , 49 ].…”