Effectiveness of a colonoscopic screening programme in first-degree relatives of patients with colorectal cancer

Gutiérrez, J.J. Puente; Moreno, Miguel Alonso Marín; Jiménez, José Luís; Blanco, Enrique Bernal; Iglesias, José Miguel Díaz

doi:10.1111/j.1463-1318.2011.02577.x

Cited by 20 publications

(26 citation statements)

References 27 publications

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“…The high rate of adenoma and ADA in the right colon of FDRs of CRC patients [22,58,59] and the occurrence of CRC in the right colon in 30%-40% of FDRs [60,61] indicate that an endoscopic assessment of the entire colon for screening purposes should be preferred to the limited exploration of the left colon. The usefulness of such a recommendation is confirmed by the growing evidence that colonoscopy-based screening programs are able to reduce CRC incidence and mortality.…”

Section: Screening Colonoscopymentioning

confidence: 99%

“…Therefore, more detailed information should be provided to subjects with a family history of CRC regarding the safety of colonoscopy and the possibility of performing the procedure under sedation. In this regard, general practitioners play a decisive role, especially in lesseducated people who are less likely to obtain information in other ways [22,58,70,71] . High-quality colonoscopy is crucial to achieve good CRC screening, therefore several technical factors have to be taken into account [37] .…”

Section: Screening Colonoscopymentioning

confidence: 99%

“…Additional risk factors are male sex and the strength of family history, increasing the risk of developing CRC or ADA by 1.5-3.0-fold [27] . The number of FDRs affected also influences the risk of ADA, being higher in asymptomatic subjects with two FDRs with CRC diagnosed at any age in comparison to asymptomatic subjects with only one FDR with CRC at age < 50 years [22] . All these risk factors have to be taken into consideration in a screening program, in order to select a subpopulation of patients with highest risk, and in whom screening investigations could be indicated earlier than in subjects without these risk factors.…”

Section: Introductionmentioning

confidence: 99%

“…Screening in familial colorectal cancer An increased rate of colonic adenoma detection is also reported in individuals with a family history of CRC in comparison with average-risk subjects [20][21][22][23][24][25][26] . Colorectal adenoma > 10 mm, with high-grade dysplasia and/or a villous component, termed as advanced adenoma (ADA), is a precursor of CRC.…”

Section: Introductionmentioning

confidence: 99%

“…Colorectal adenoma > 10 mm, with high-grade dysplasia and/or a villous component, termed as advanced adenoma (ADA), is a precursor of CRC. Several colonoscopy-based screening studies [21][22][23][24][25] reported an increased prevalence of ADA in FDRs of CRC patients, ranging from 3.3% to 21.3%, in relation to average-risk subjects in whom it was defined as 1.9%-11.5%. A high prevalence of ADA has also been described among young FDRs aged 40-45 years, which increased with age [25] .…”

Section: Introductionmentioning

confidence: 99%

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Familial colorectal cancer screening: When and what to do?

Blanco¹,

Paoluzi²,

Sileri³

et al. 2015

WJG

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Colorectal cancer (CRC) is the third leading cause of death worldwide and represents a clinical challenge. Family members of patients affected by CRC have an increased risk of CRC development. In these individuals, screening is strongly recommended and should be started earlier than in the population with average risk, in order to detect neoplastic precursors, such as adenoma, advanced adenoma, and nonpolypoid adenomatous lesions of the colon. Fecal occult blood test (FOBT) is a non invasive, widespread screening method that can reduce CRC-related mortality. Sigmoidoscopy, alone or in addition to FOBT, represents another screening strategy that reduces CRC mortality. Colonoscopy is the best choice for screening highrisk populations, as it allows simultaneous detection and removal of preneoplastic lesions. The choice of test depends on local health policy and varies among countries. Core tip: One-fifth of people who develop colorectal cancer (CRC) have a first-degree relative (FDR) affected by this malignancy. Screening is an efficient method to reduce mortality for CRC and should be started in FDRs earlier than in the population at average risk. There is a large disparity in guidelines for screening in familial CRC, therefore, here we address the principal indication and methods for screening in this population at increased risk. Recent or emerging methods to improve the participation rate in screening programs are described. Ongoing trials on CRC screening are also reported.

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Section: Screening Colonoscopymentioning

confidence: 99%

Section: Screening Colonoscopymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Familial colorectal cancer screening: When and what to do?

Blanco¹,

Paoluzi²,

Sileri³

et al. 2015

WJG

View full text Add to dashboard Cite

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Advanced colonic neoplasia in the first degree relatives of colon cancer patients: A colonoscopy‐based study

Salimzadeh

Bishehsari

Amani

et al. 2016

Intl Journal of Cancer

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We aimed to determine the risk of advanced neoplasms among a cohort of asymptomatic first degree relatives (FDRs) of patients with sporadic colorectal cancer (CRC) compared with matched controls. Data for patients with a diagnosis of CRC made between September 2013 and August 2014 were obtained from a population-based cancer registry system in Tehran. Screening colonoscopies were done for 342 FDRs and the findings were compared to those from 342 age- and gender-matched healthy controls without a family history of CRC. We reported the association as conditional Odds Ratio (OR) using Mantel Hazel and Logistic regression. The prevalence of advanced neoplasia was 13.2% among FDRs and 3.8% in controls (matched OR [mOR], 4.0, 95% confidence interval [CI], 2.1 - 7.6; p < 0.001). In FDRs aged 40-49 years, the prevalence of advanced neoplasia was significantly higher than in their matched controls (mOR, 6.8, 95% CI, 1.5-31.4; p = 0.01). Family history of CRC in at least one FDR was the strongest predictor of advanced neoplasia (adjusted OR, 4.0, 95% CI: 2.1-7.6; p < 0.001). The age of the index case at diagnosis did not predict the presence of advanced colonic neoplasms in their FDRs. Our study indicates a high risk of advanced neoplasia in FDRs of CRC cases, where only eight colonoscopies are needed to detect one advanced neoplasia. Our data suggest that all FDRs, regardless of the age of CRC diagnosis in their index case, should be considered for a targeted early screening.

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Risque de néoplasie rectocolique en cas d’antécédent familial de carcinome ou d’adénome rectocolique. Faut-il revoir les recommandations de dépistage en 2014 ?

Héresbach

2014

Acta Endosc

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Effectiveness of a colonoscopic screening programme in first-degree relatives of patients with colorectal cancer

Abstract: We detected advanced neoplasia in a considerable number of participants. Our data support colonoscopy screening in first-degree relatives of patients with CRC at an earlier age than in the medium-risk population. Male sex and sibling relationship were predictors of advanced neoplasia.

Cited by 20 publications

References 27 publications

Familial colorectal cancer screening: When and what to do?

Familial colorectal cancer screening: When and what to do?

Advanced colonic neoplasia in the first degree relatives of colon cancer patients: A colonoscopy‐based study

Risque de néoplasie rectocolique en cas d’antécédent familial de carcinome ou d’adénome rectocolique. Faut-il revoir les recommandations de dépistage en 2014 ?

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