Effectiveness of a cranberry (<i>Vaccinium macrocarpon</i>) preparation in reducing asymptomatic bacteriuria in patients with an ileal enterocystoplasty

Botto, Henry; Neuzillet, Y.

doi:10.3109/00365591003636596

Cited by 20 publications

(14 citation statements)

References 17 publications

(16 reference statements)

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“…This bacteriuria has been independantly studied by our department. A new preventive approach using a cranberry (Vaccinium macrocarpon) preparation has been efficient in our patients for reducing this bacteriuria [33].…”

Section: Discussionmentioning

confidence: 99%

The Z‐shaped ileal neobladder after radical cystectomy: an 18 years experience with 329 patients

et al. 2011

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Eighty-three early complications in 80/294 patients (27.2%) occurred. The average Clavian rate of these early complications was 2.24. Among these, 12 complications in 12 patients (4.1%) were pouch-related, and 3 reoperations were required. Two patients died from cardiac complications. Sixty-three late complications in 60/294 patients (20.4%) were recorded. The average Clavian rate of these late complications was 2.98. Among these, 47 complications in 45/294 patients (15.3%) were pouch-related, and 18 reoperations were required, essentially for ureteral anastomosis stricture.Satisfactory daytime urinary continence was achieved in 92% of patients. Daytime continence was obtained within, on average, 6.8 ± 16.4 months. The interval between each daytime urination was 2.6 ± 0.8 h (median = 2.5 [1-5] h). Forty-four (15%) patients developed metabolic acidosis which only required oral medication.Satisfactory nocturnal urinary continence was achieved in 87% of patients. Night-time continence was obtained within, on average, 10.8 ± 22.4 months.Hyper-continence with subsequent need for CISC was observed in 4%. CONCLUSIONIn our series of 329 patients, compared with the other techniques, the Z-shaped ileal neobladder had an 'expected' complication rate for this high risk surgery with satisfactory daytime and night-time continence in nine out of ten patients.

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Section: Discussionmentioning

confidence: 99%

The Z‐shaped ileal neobladder after radical cystectomy: an 18 years experience with 329 patients

et al. 2011

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“…The comments received indicated that the applicant did not agree with the conclusion of the Panel that the results of the study by Botto and Neuzillet (2010) obtained in a population of patients after radical cystectomy and ileal cystoplasty cannot be extrapolated to the target population (i.e. general population) for this claim.…”

Section: Comments Related To the Panel's Assessment Of The Study By Bmentioning

confidence: 97%

Response to comments on the Scientific Opinion on the substantiation of a health claim related to proanthocyanidins in Urell® and reduction of bacterial colonisation of the urinary tract by inhibition of the adhesion of P‐fimbriated E. coli to uroepithelial cells pursuant to Article 13.5 of Regulation (EC) No 1924/2006

2013

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“…The literature reveals that the consumption of cranberry (Vaccinium macrocarpon) juice helps prevent UTI [6][7][8][9][10][11]; it has been used by Native Americans for more than 200 years [12]. Several theories regarding the effect of cranberry juice have been proposed by different studies [6].…”

Section: Introductionmentioning

confidence: 99%

“…Another compound-proanthocyanidin-identified in the cranberry juice is found responsible and considered to be the main active ingredient for inhibiting P-fimbriated E. coli adherence to uroepithelial cells [8]. The inhibition of adherence activity of this compound has been observed not only to sensitive but also for trimethoprim-sulfamethoxazoleresistant uropathogens [9] and to asymptomatic bacteriuria in patients with an ileal enterocystoplasty [11]. Furthermore, it has not been evaluated and investigated with multi-drug resistant uropathogens, which remains unexplored to date.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of adherence of multi-drug resistant E. coli by proanthocyanidin

et al. 2011

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Proanthocyanidin is commonly used for inhibiting urinary tract infection (UTI) of sensitive strains of Escherichia coli. The aim of this study was to investigate the effect of proanthocyanidin on adherence of uropathogenic multi-drug resistant E. coli to uroepithelial cells, which has not yet been investigated so far. Extracts of the purified proanthocyanidin were prepared from dried cranberry juice. Purity and structural assignment of proanthocyanidin was assessed using high performance liquid chromatography and 13 C nuclear magnetic resonance spectroscopy, respectively. Subsequently, its affect on multi-drug resistant bacteria as well as quantification of anti-adherence bioactivity on human vaginal and bladder epithelial cells was appraised. Inhibition of adherence to an extent of about 70% with multi-drug resistant E. coli strains was observed on uroepithelial cell. The anti-adherence bioactivity of the proanthocyanidin was detected at concentrations of 10-50 lg/ml with significant bacteriuria. Probable proanthocyanidin through A-type linkages either combines to P-fimbriae of bacterial cells or modifies the structural entity of P-fimbriae and inhibits bacterial adherence to uroepithelial cells. The proanthocyanidin exhibited anti-adherence property with multi-drug resistant strains of uropathogenic P-fimbriated E. coli with in vitro study. Hence proanthocyanidin may be considered as an inhibitory agent for multi-drug resistant strains of E. coli adherence to uroepithelial cells.

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Effectiveness of a cranberry (Vaccinium macrocarpon) preparation in reducing asymptomatic bacteriuria in patients with an ileal enterocystoplasty

Abstract: Treatment with a cranberry compound seems to be effective in reducing asymptomatic bacteriuria in patients with an ileal enterocystoplasty. These results need to be validated by further double-blind randomized studies.

Cited by 20 publications

References 17 publications

The Z‐shaped ileal neobladder after radical cystectomy: an 18 years experience with 329 patients

The Z‐shaped ileal neobladder after radical cystectomy: an 18 years experience with 329 patients

Inhibition of adherence of multi-drug resistant E. coli by proanthocyanidin

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