Effectiveness of a Hydrogen Peroxide Mist (Trophon) System in Inactivating Healthcare Pathogens on Surface and Endocavitary Probes

Rutala, William A.; Gergen, Maria F.; Sickbert-Bennett, Emily E.

doi:10.1017/ice.2016.11

Cited by 13 publications

(10 citation statements)

References 7 publications

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“…The Trophon EPR system showed good, but not complete, inactivation of Mycobacterium terrae (5.2-log 10 reduction for M terrae with FCS, a 4.6-log 10 reduction for M terrae without FCS) and C difficile spores (5.1-log 10 reduction for C difficile spores with FCS, 6.2-log 10 reduction for C difficile spores without FCS). 89 To simulate a worse-case condition, cleaning was not done before disinfection in these experiments; but proper cleaning of probes is necessary to ensure the success of high-level disinfection. Other data have demonstrated the activity of Trophon to inactivate human papilloma virus 88 and other pathogens (eg, bacteria, mycobacteria, viruses) including a greater than 6-log 10 reduction of M terrae and C difficile spores in carrier tests and a greater than 6-log 10 reduction in M terrae on inoculated ultrasound probes.…”

Section: Hydrogen Peroxide Mist System For Probesmentioning

confidence: 99%

“…In the authors' study only the probe devices were inoculated (carriers of different materials were not tested); for recovery of bacteria on the probe, the probes were immersed in media (not swabbed, which would likely result in lower recovery). 89 The Trophon system processes the portion of the probe that has mucous membrane contact but also the handle of endocavitary probes, which may be contaminated; it is an alternative to high-level chemical disinfection for ultrasound probes.…”

Section: Hydrogen Peroxide Mist System For Probesmentioning

confidence: 99%

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Disinfection and Sterilization in Health Care Facilities

Rutala

Weber

2016

Infectious Disease Clinics of North America

Self Cite

161

104

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Section: Hydrogen Peroxide Mist System For Probesmentioning

confidence: 99%

Section: Hydrogen Peroxide Mist System For Probesmentioning

confidence: 99%

Disinfection and Sterilization in Health Care Facilities

Rutala

Weber

2016

Infectious Disease Clinics of North America

Self Cite

161

104

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“…The Trophon EPR system (Nanosonics, Indianapolis, IN) showed good, but not complete, inactivation of M terrae (5.2log 10 reduction for M terrae with FCS; 4.6-log 10 reduction for M terrae without FCS) and C difficile spores (5.1-log 10 reduction for C difficile spores with FCS; 6.2-log 10 reduction for C difficile spores without FCS). 117 Other data have demonstrated the activity of Trophon to inactivate HPV 118 and other pathogens (eg, bacteria, mycobacteria, viruses) including a >6-log 10 reduction of M terrae and C difficile spores in carrier tests and a >6-log 10 reduction in M terrae on inoculated ultrasound probes. 119 These results differ slightly from those presented earlier, presumably because of the differences in testing methodology.…”

Section: Hydrogen Peroxide Mist System For Probesmentioning

confidence: 99%

“…In our study, only the probe devices were inoculated (carriers of different materials were not tested) and for recovery of bacteria on the probe, the probes were immersed in media (not swabbed, which would likely result in lower recovery). 117 The Trophon system processes the portion of the probe that has mucous membrane contact but also the handle of an endocavitary probe, which may be contaminated, and it is an alternative to high-level chemical disinfection for ultrasound probes.…”

Section: Hydrogen Peroxide Mist System For Probesmentioning

confidence: 99%

Reprocessing semicritical items: Outbreaks and current issues

Rutala

Weber

2019

American Journal of Infection Control

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Semicritical medical devices are defined as items that come into contact with mucous membranes or nonintact skin (eg, gastrointestinal endoscopes, endocavitary probes). Such medical devices require minimally high-level disinfection. As many of these items are temperature sensitive, low-temperature chemical methods must be used rather than steam sterilization. Strict adherence to current guidelines is required as more outbreaks have been linked to inadequately cleaned or disinfected endoscopes and other semicritical items than any other reusable medical devices.

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“…Hydrogen peroxide had high efficacy and was found to be effective against HPV 16, HPV 18, and certain mycobacterium. 27,35,36,39,41,42 PAA also had high efficacy and was found effective against HPV 16, antibiotic-resistant bacteria, and certain mycobacterium. 25,27,36,43 There was no information available on the efficacy of PAA against HPV 18.…”

Section: Alternative Hldsmentioning

confidence: 99%

Reviewing the Use of Glutaraldehyde for High-level Disinfection by Sonographers

Pearlman

2018

Journal of Diagnostic Medical Sonography

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Infection control is becoming a vital issue in sonography practices. 1 Soiled ultrasound transducers pose the risk of cross-contamination as they are used from one patient to the next. 2 There has been a wave of recent data underscoring the risk of infection from ultrasound transducers, triggering the American Institute of Ultrasound in Medicine (AIUM) to release guidelines 3 on the importance of cleaning ultrasound transducers and highlighting the necessity for effective high-level disinfection (HLD). According to the AIUM guidelines, 3 ultrasound transducers need to undergo high-level disinfection, which should include intracavitary transducers such as transesophageal, rectal, vaginal, and intraoperative transducers, as well as transducers that come in contact with bodily fluids, blood, or cracked skin. These intracavitary transducers are classified as semi-critical devices. In addition to high-level disinfection, transducer covers should be utilized for all transducers that may come in contact with blood or bodily fluids. High-level disinfection (HLD) is defined as the destruction of all microorganisms except for bacterial spores. 3 The use of HLD is specific to equipment, such as transducers, that are sensitive to heat but can be exposed to liquids. 4 The AIUM does not endorse any specific HLDs as part of the guidelines. The guidelines do indicate that precautions should be taken to protect workers and patients from the toxicity of chemical disinfectants. 3 The AIUM guidelines provide a reference to the FDA website, since this is the agency that regulates HLDs. 3 There are 36 cleared HLDs on the FDA website as of 2018. 5 Of the 36 HLDs, 56% are glutaraldehyde (GA)based (See Table 1). This review of the literature focuses on the use of GA, since such a high percent of FDAapproved HLDs are GA-based. The breakdown of GA is as follows. The molecular formula for GA is C 5 H 8 O 2 and the chemical abstract service (CAS) registry number is 111-30-8. 6 The permissible exposure limit for GA set by the National Institute of Occupational Safety and Health (NIOSH) is 0.2 parts per million (ppm), while the American Conference of Governmental Industrial Hygienists and the United Kingdom Health and Safety Executive have a threshold limit value of 0.05 ppm. 4 813361J DMXXX10.

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Effectiveness of a Hydrogen Peroxide Mist (Trophon) System in Inactivating Healthcare Pathogens on Surface and Endocavitary Probes

Cited by 13 publications

References 7 publications

Disinfection and Sterilization in Health Care Facilities

Disinfection and Sterilization in Health Care Facilities

Reprocessing semicritical items: Outbreaks and current issues

Reviewing the Use of Glutaraldehyde for High-level Disinfection by Sonographers

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