Effectiveness of a Skin Care Program With a Cream Containing Ceramide C and a Personalized Training for Secondary Prevention of Hand Contact Dermatitis

Filon, Francesca Larese; Maculan, Pietro; Crivellaro, Maria Angiola; Mauro, Marcella

doi:10.1089/derm.2022.29002.flf

Cited by 4 publications

(1 citation statement)

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“…Alterations in Ceramide content in the skin are associated with a number of skin diseases including atopic dermatitis (AD) [3,4]. Supplementation of Ceramides [5] or the use of Ceramide-like creams [6] have been shown to ameliorate dry skin symptoms in the skin of patients with AD, or in patients with contact dermatitis [7], and to assist in the formation of the permeability barrier which in turn can heal damage to the skin barrier [8,9]. Interestingly, some Ceramides have been shown to have inhibitory properties against proteases [10].…”

Section: Introductionmentioning

confidence: 99%

Ceramide AD™ Restores Skin Integrity and Function following Exposure to House Dust Mite

Bzioueche,

Tamelghaghet,

Chignon-Sicard

et al. 2023

IJMS

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Ceramides are epidermal lipids important for normal skin barrier function. Reduced Ceramide content is associated with atopic dermatitis (AD). House dust mite (HDM) has been localized in AD skin where it plays an exacerbator role. We set to examine the impact of HDM on skin integrity and the effect of three separate Ceramides (AD™, DS, Y30) on HDM-induced cutaneous damage. The effect was tested in vitro on primary human keratinocytes and ex vivo on skin explants. HDM (100 μg/mL) decreased the expression of adhesion protein E-cadherin, supra-basal (K1, K10) and basal (K5, K14) keratins and increased matrix metallopeptidase (MMP)-9 activity. The presence of Ceramide AD™ in topical cream inhibited HDM-induced E-cadherin and keratin destruction and dampened MMP-9 activity ex vivo which was not seen for the control cream or cream containing DS or Y30 Ceramides. The efficacy of Ceramide AD™ was tested in a clinical setting on moderate to very dry skin (as surrogate for environment-induced skin damage). When applied topically for 21 days, Ceramide AD™ significantly reduced transepidermal water loss (TEWL) in patients with very dry skin compared to their TEWL baseline data. Our study demonstrates Ceramide AD™ cream to be effective in restoring skin homeostasis and barrier function in damaged skin and warrants testing in larger clinical trials for possible treatment of AD and xerosis.

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Section: Introductionmentioning

confidence: 99%

Ceramide AD™ Restores Skin Integrity and Function following Exposure to House Dust Mite

Bzioueche,

Tamelghaghet,

Chignon-Sicard

et al. 2023

IJMS

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Hand eczema symptoms, exposures and skin care in orthodontics

Wiechens,

Meyer-Marcotty,

Buhl

et al. 2024

J Orofac Orthop

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Objectives Occupational hand eczema is a common inflammatory skin condition among healthcare professionals. Orthodontists are frequently exposed to a variety of irritating and allergenic substances, and therefore they belong to a predisposed group to develop hand eczema. However, current data on the prevalence and predisposing factors among orthodontists to provide adequate prophylaxis are lacking. Methods An anonymous online survey was conducted in Germany between January and February 2023 and distributed to 2402 orthodontists. The questionnaire addressed general information on current skin status, as well as occupational skin exposure and skin care. Results A total of 209 orthodontists responded to the survey. Seventy-four percent reported experiencing hand eczema-specific symptoms within the last 12 months, with 24% describing moderate and 10% describing severe symptoms. The average daily glove wearing time was stated to be 6 ± 2 h. The most frequently reported triggers at work were frequent hand washing (62.7%) and hand disinfection (59.1%). Among all the respondents, 22.6% stated not using either barrier cream or moisturizer. Conclusions This study showed a high prevalence of hand eczema symptoms among orthodontists, which is probably due to frequent disinfection, hand washing, and contact with allergens such as acrylates. In this professional group especially, against a background of future increasing acrylate and epoxy resin exposures due to in-office three-dimensional printing processes, timely education and skin protection could decisively counteract the pathogenesis of hand eczema.

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Biomonitoring of hand and forearm transepidermal water loss and skin pH among nursing apprentices

Babić,

Šakić,

Macan

2024

Contact Dermatitis

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BackgroundMeasurements of transepidermal water loss (TEWL) and stratum corneum (SC) pH can help indicate work‐related skin barrier damage, but sensitivity to confounding personal and ambient factors limits their potential as biomonitoring tools.ObjectivesTo evaluate the difference between hand and forearm skin barrier conditions as a tool for early recognition of workers with occupational contact dermatitis.Participants and MethodsThe participants were nursing apprentices (N = 238, median age 19 years) from Zagreb, Croatia. They filled out a questionnaire based on the Nordic Occupational Skin Questionnaire, underwent a clinical examination of skin on the hands, and were evaluated for their TEWL and SC pH on the dorsum of the hand and volar part of the forearm.ResultsWe found that the difference between hand and forearm TEWL values (ΔTEWL) greater than 7 g/m2/h, or >50%, or the difference in SC ΔpH >0.50, predicted visible skin changes found on clinical examination. However, only the association with ΔpH >0.50 retained statistical significance when controlled for sex, age, ambient temperature, and relative humidity in a multiple regression model.ConclusionsThe difference between hand and forearm SC pH values is suggested as a reliable biomonitoring tool in recognition of damaged skin barrier conditions in occupational settings.

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Effectiveness of a Skin Care Program With a Cream Containing Ceramide C and a Personalized Training for Secondary Prevention of Hand Contact Dermatitis

Cited by 4 publications

References 50 publications

Ceramide AD™ Restores Skin Integrity and Function following Exposure to House Dust Mite

Ceramide AD™ Restores Skin Integrity and Function following Exposure to House Dust Mite

Hand eczema symptoms, exposures and skin care in orthodontics

Biomonitoring of hand and forearm transepidermal water loss and skin pH among nursing apprentices

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