This paper reviews recent, nurse-led telehealth research with the goal of describing research findings that provide evidence for practice. Methods: Using an iterative search method, of eight electronic databases, 84 nurse-led research papers were separated into intervention research, systematic reviews and meta-analyses, and descriptive research. The main emphasis was on full text analysis of the intervention research. Results: Fifteen intervention research papers reported findings related to cardiovascular disease, diabetes mellitus, older age, young adults, early adolescents, children with special health care needs, people with a stoma, post-partum mothers and nurses. Also reviewed for useable evidence for practice were 10 systematic reviews, two meta-analyses and two papers that described reviews plus meta-analyses. Resuts: Fifty-five papers with descriptive designs are briefly described. Nurse-led intervention research is increasing knowledge about the use of telehealth technology and applications in care delivery. People with healthcare needs do better with individual attention and increased follow-up. People have a tolerance for technology used with them to advance their quality of life and healing but there is a point at which too much technology is overwhelming. Clinical research is a challenge due to the number of extraneous variables that are difficult to control and that can affect a person’s response to the research intervention. Conclusion: Continuation of nurse-led telehealth intervention research will help to ensure that technology used to support and advance care delivery will be evidence-based.