Effectiveness of acute transcranial direct current stimulation on non-motor and motor symptoms in Parkinson’s disease

Bueno, Maria Eduarda Brandão; Neto, Luiz Inácio do Nascimento; Terra, Marcelle Brandão; Barboza, Natália Mariano; Okano, Alexandre Hideki; Smaili, Suhaila Mahmoud

doi:10.1016/j.neulet.2018.12.017

Cited by 34 publications

(44 citation statements)

References 34 publications

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“…The stimulation facilitates or inhibits spontaneous neuronal activity putatively resulting in cortical excitability modulation [4–7] and neuroplastic reorganization [8–11]. tDCS has been used in neuropsychiatric [12–14] and neurological disorders [15–19], modulation of autonomic nervous system [20–23], appetite [24–26], energy expenditure [27], motor performance [21, 28, 29] and motor learning [8, 30–33]. More recently, a high-definition-tDCS (HD-tDCS) was developed with arrays of smaller “high-definition” electrodes to increase brain modulation accuracy [34, 35].…”

Section: Introductionmentioning

confidence: 99%

Beyond the target area: an integrative view of tDCS-induced motor cortex modulation in patients and athletes

Morya

Monte-Silva

Bikson

et al. 2019

J NeuroEngineering Rehabil

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116

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Transcranial Direct Current Stimulation (tDCS) is a non-invasive technique used to modulate neural tissue. Neuromodulation apparently improves cognitive functions in several neurologic diseases treatment and sports performance. In this study, we present a comprehensive, integrative review of tDCS for motor rehabilitation and motor learning in healthy individuals, athletes and multiple neurologic and neuropsychiatric conditions. We also report on neuromodulation mechanisms, main applications, current knowledge including areas such as language, embodied cognition, functional and social aspects, and future directions. We present the use and perspectives of new developments in tDCS technology, namely high-definition tDCS (HD-tDCS) which promises to overcome one of the main tDCS limitation (i.e., low focality) and its application for neurological disease, pain relief, and motor learning/rehabilitation. Finally, we provided information regarding the Transcutaneous Spinal Direct Current Stimulation (tsDCS) in clinical applications, Cerebellar tDCS (ctDCS) and its influence on motor learning, and TMS combined with electroencephalography (EEG) as a tool to evaluate tDCS effects on brain function.

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Section: Introductionmentioning

confidence: 99%

Beyond the target area: an integrative view of tDCS-induced motor cortex modulation in patients and athletes

Morya

Monte-Silva

Bikson

et al. 2019

J NeuroEngineering Rehabil

Self Cite

116

View full text Add to dashboard Cite

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“…Nitsche & Paulus, 2000). This predictability has led to recent investigation into tDCS application in pathological population including Parkinson's disease (Broeder et al, 2019;Bueno et al, 2019), epilepsy (Lin et al, 2018;Tecchio et al, 2018) stroke rehabilitation (Biou et al, 2019;Solomons & Shanmugasundaram, 2019), cerebral palsy (Inguaggiato et al, 2019), chronic pain (Callai et al, 2019;Jafarzadeh et al, 2019), depression (Aparicio et al, 2019) and cognitive impairment (Emonson et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Can genetic polymorphisms predict response variability to anodal transcranial direct current stimulation of the primary motor cortex?

Pellegrini

Zoghi

Jaberzadeh

2020

Preprint

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Genetic mediation of cortical plasticity and the role genetic variants play in previously observed response variability to transcranial direct current stimulation (tDCS) have become important issues in the tDCS literature in recent years. This study investigated whether inter-individual variability to tDCS was in-part genetically mediated. In sixty-one healthy males, anodal-tDCS (a-tDCS) andsham-tDCS were administered to the primary motor cortex at 1mA for 10-minutes via 6x4cm active and 7x5cm return electrodes. Twenty-five single-pulse transcranial magnetic stimulation (TMS) motor evoked potentials (MEP) were recorded to represent corticospinal excitability (CSE).Twenty-five paired-pulse MEPs were recorded with 3ms inter-stimulus interval (ISI) to assess intracortical inhibition (ICI) via short-interval intracranial inhibition (SICI) and 10ms ISI for intracortical facilitation (ICF). Saliva samples tested for specific genetic polymorphisms in genes encoding for excitatory and inhibitory neuroreceptors. Individuals were sub-grouped based on a pre-determined threshold and via statistical cluster analysis. Two distinct subgroups were identified, increases in CSE following a-tDCS (i.e. Responders) and no increase or even reductions in CSE (i.e. Non-responders). No changes in ICI or ICF were reported. No relationships were reported between genetic polymorphisms in excitatory receptor genes and a-tDCS responders. An association was reported between a-tDCS responders and GABRA3 gene polymorphisms encoding for GABA-A receptors suggesting potential relationships between GABA-A receptor variations and capacity to undergo tDCS-induced cortical plasticity. In the largest tDCS study of its kind, this study presents an important step forward in determining the contribution genetic factors play in previously observed inter-individual variability to tDCS.

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“…One study tested in both off and on dopaminergic medication [ 33 ], one tested in the off state [ 49 ], and one did not report medication status [ 52 ]. Five investigations had open-label designs [ 38 , 43 , 45 , 46 , 47 ]; seven were parallel arm, randomized, double-blind, sham-controlled designs [ 33 , 40 , 41 , 42 , 44 , 50 , 52 ]; and eight were crossover, randomized, sham-controlled designs, with six being double-blind [ 36 , 37 , 39 , 48 , 49 , 51 ] and two with unstated blinding [ 34 , 35 ]. The tDCS intensities ranged from 1 to 2.8 mA (range of current densities = 0.02 mA/cm 2 –0.12 mA/cm 2 ) and stimulation was applied for 7–30 min (mode = 20 min).…”

Section: Resultsmentioning

confidence: 99%

Tolerability and Blinding of Transcranial Direct Current Stimulation in People with Parkinson’s Disease: A Critical Review

2020

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Transcranial direct current stimulation (tDCS) is accompanied by transient sensations (e.g., tingling, itching, burning), which may affect treatment outcomes or break the blinding of the study protocol. Assessing tolerability and blinding is integral to providing ample evidence of a “real effect” from the applied stimulation and dispelling the possibility of placebo effects. People with Parkinson’s disease (PwPD) endure many motor and non-motor symptoms that might be amenable to tDCS. However, because the disease also affects sensation capabilities, these subjects might report tolerability and blinding differently than other cohorts. Therefore, the purpose of this review was to aggregate the tolerability and blinding reports of tDCS studies in PwPD and recommend a standard tolerability and blinding reporting practice. A literature search of the PubMed and Scopus databases from 1 January 2020 to 1 April 2020 was performed to identify publications that applied tDCS to PwPD. Seventy studies were potentially reviewable, but only 36 (nine with quantitative tolerability reports, 20 with qualitative tolerability reports, and seven that only reported blinding) provided sufficient information to be included in the review. Quantitative information on tDCS tolerability and blinding maintenance in PwPD is scarce, and future reviews and metanalyses should carefully consider the possibility of placebo effects in their included studies.

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Effectiveness of acute transcranial direct current stimulation on non-motor and motor symptoms in Parkinson’s disease

Cited by 34 publications

References 34 publications

Beyond the target area: an integrative view of tDCS-induced motor cortex modulation in patients and athletes

Beyond the target area: an integrative view of tDCS-induced motor cortex modulation in patients and athletes

Can genetic polymorphisms predict response variability to anodal transcranial direct current stimulation of the primary motor cortex?

Tolerability and Blinding of Transcranial Direct Current Stimulation in People with Parkinson’s Disease: A Critical Review

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