Coronary heart disease, the most prevalent non-communicable disease, poses both physical and psychological challenges, including anxiety and depression. Addressing these issues requires a holistic approach that integrates biological, psychological, social, and spiritual dimensions. Spiritual care interventions can alleviate psychological distress and enhance patient satisfaction in nursing care. This study explored the impact of combining spiritual care with murottal auditory therapy to reduce anxiety and depression in patients with coronary heart disease. In this quasi-experimental study, 110 participants were divided into intervention and control groups, each with 55 participants selected based on specific criteria. Anxiety and depression levels were assessed using the validated Depression Anxiety Stress Scale (DASS). The intervention group received daily murottal therapy sessions lasting 15 to 20 minutes for three days at Siti Khadijah Islamic Hospital in Palembang from March to July 2023. Pre-test and post-test assessments were conducted. The results indicated that a significant proportion of patients in the intervention group experienced mild anxiety (52.7%) and reduced depression (65.5%) after murottal therapy. Significant differences in anxiety and depression levels were observed between the intervention and control groups, with p-values of 0.000 for both. murottal auditory therapy, mainly using Surah Ar-Rahman, effectively reduces anxiety and depression in patients with coronary heart disease, offering a promising complementary treatment approach.