Effectiveness of an 8-Week Aerobic Exercise Program on Autonomic Function in People Living with HIV Taking Anti-Retroviral Therapy: A Pilot Randomized Controlled Trial

Quiles, Norberto; Taylor, Barbara S.; Ortíz, Alexis

doi:10.1089/aid.2019.0194

Cited by 6 publications

(7 citation statements)

References 29 publications

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“…For the most part, men have higher HRV than women (e.g., Koenig & Thayer, 2016 ) though age is also a factor (Stein et al, 1997 ). The SDNN values in our study were also lower than those reported by Quiles and colleagues ( 2020 ), both before and after their aerobic exercise intervention. Also, we did not measure HRV in people without HIV so we are not able to report on the impact of HIV itself on HRV; however, others have reported decreased low- and high-frequency HRV in people with AIDS (Neild et al, 2000 ).…”

Section: Discussioncontrasting

confidence: 68%

“…For example, HRV increased with training five times a week for four weeks in sedentary middle-aged women (Masroor et al, 2018 ). Another study reported greater SDNN in people living with HIV following eight weeks of aerobic exercise, practiced three times a week (Quiles et al, 2020 ), but no difference in frequency-domain measures of HRV (Quiles et al, 2020 ). Another study assessed HRV prior to, during, and after 20 min of treadmill exercise (performed at 60% of maximum oxygen intake) (Borges et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

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Meditation and Aerobic Exercise Enhance Mental Health Outcomes and Pattern Separation Learning Without Changing Heart Rate Variability in Women with HIV

Millon

Lehrer

Shors

2022

Appl Psychophysiol Biofeedback

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Mental and physical (MAP) training targets the brain and the body through a combination of focused-attention meditation and aerobic exercise. The following feasibility pilot study tested whether 6 weeks of MAP training improves mental health outcomes, while enhancing discrimination learning and heart rate variability (HRV) in a group of women living with human immunodeficiency virus (HIV) and other stress-related conditions. Participants were assigned to training ( n = 18) or no-training control ( n = 8) groups depending on their ability and willingness to participate, and if their schedule allowed. Training sessions were held once a week for 6 weeks with 30 min of meditation followed by 30 min of aerobic exercise. Before and after 6 weeks of training, participants completed the Behavioral Pattern Separation Task as a measure of discrimination learning, self-report questionnaires of ruminative and trauma-related thoughts, depression, anxiety, and perceived stress, and an assessment of HRV at rest. After training, participants reported fewer ruminative and trauma-related thoughts, fewer depressive and anxiety symptoms, and less perceived stress ( p ’s < 0.05). The positive impact on ruminative thoughts and depressive symptoms persisted 6 months after training. They also demonstrated enhanced discrimination of similar patterns of information ( p < 0.05). HRV did not change after training ( p > 0.05). Combining mental and physical training is an effective program for enhancing mental health and aspects of cognition in women living with HIV, although not necessarily through variance in heart rate.

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Section: Discussioncontrasting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Meditation and Aerobic Exercise Enhance Mental Health Outcomes and Pattern Separation Learning Without Changing Heart Rate Variability in Women with HIV

Millon

Lehrer

Shors

2022

Appl Psychophysiol Biofeedback

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“…Especially aerobic training has been described as an optimal form to reduce risks of cardiovascular diseases and enhancing parasympathetic activity. Numerous studies have shown an increase in HRV after aerobic exercise interventions in healthy adults (Carter et al, 2003;Iwasaki et al, 2003;Tulppo et al, 2003), in elderly (Levy et al, 1998;Schuit et al, 1999;Stein et al, 1999;Albinet et al, 2010), and in people with various diseases (Zoppini et al, 2007;Borghi-Silva et al, 2015;Quiles et al, 2019). However, the effects of other types of physical interventions on HRV is still not clear.…”

Section: Introductionmentioning

confidence: 99%

Effects of Different Training Interventions on Heart Rate Variability and Cardiovascular Health and Risk Factors in Young and Middle-Aged Adults: A Systematic Review

et al. 2021

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Introduction: Heart rate variability (HRV), the beat-to-beat variation of adjacent heartbeats, is an indicator of the function of the autonomic nervous system (ANS). Increased HRV reflects well-functioning of autonomic control mechanism and cardiovascular health. The aim of this systematic review is to provide a systematic overview of the effects of different physical training modalities on resting HRV and cardiovascular health and risk factors (i.e., baroreflex sensitivity, body fat, body mass, body mass index, blood pressure, heart rate recovery, VO2 max, and VO2 peak) in young and middle-aged (mean age of the studies samples up to 44 years), healthy adults.Methods: A systematic review in accordance with the PRISMA guidelines was performed. Studies investigating the effects of different physical interventions (endurance, resistance, high-intensity, coordinative, or multimodal training) on HRV were included. Trials were considered eligible if the intervention lasted for at least 4 weeks and participants were regarded as general healthy. Five electronic databases were searched from 2005 to September 8th, 2020. The methodological quality of eligible studies was assessed by two study quality and reporting assessment scales (TESTEX and STARDHRV). PROSPERO registration number: CRD42020206606.Results: Of 3,991 retrieved records, 26 were considered eligible and analyzed. Twelve studies used an endurance training (of which three included high-intensity sessions), six studies resistance training, four studies coordinative training, two studies high-intensity training, and two studies used a multimodal intervention. Overall, the results showed for all types of intervention an improvement in linear and non-linear HRV parameters and cardiovascular health and risk factors. However, quality assessment revealed some methodological and reporting deficits.Conclusion: This systematic review highlights the benefits of different types of physical training interventions on autonomic function and health parameters in young and middle-aged, healthy adults. In conclusion, higher training intensities and frequencies are more likely to improve HRV. For future studies, we recommend adhering to the criteria of methodological standards of exercise interventions and HRV measurements and encourage the use of non-linear HRV parameters.

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“…Most studies addressing the effects of exercise training in PLHIV have focused on physical fitness, body composition, immune function, mental health or lipid profile [40][41][42], whereas the neurocardiovascular function of these patients has gained little attention. To the best of our knowledge, there are only two clinical trials investigating the role of exercise training on the autonomic function in PLHIV [43,44]. Quiles et al [43] have recently demonstrated that an 8-week aerobic exercise program improved the overall autonomic function of these patients, while Pedro et al [44] did not observe changes in HRV after 16 weeks of concurrent training.…”

Section: Discussionmentioning

confidence: 99%

“…To the best of our knowledge, there are only two clinical trials investigating the role of exercise training on the autonomic function in PLHIV [43,44]. Quiles et al [43] have recently demonstrated that an 8-week aerobic exercise program improved the overall autonomic function of these patients, while Pedro et al [44] did not observe changes in HRV after 16 weeks of concurrent training. Additionally, we could not locate studies investigating the role of exercise training on the muscle metaboreflex among these patients.…”

Section: Discussionmentioning

confidence: 99%

The effects of exercise training on autonomic and hemodynamic responses to muscle metaboreflex in people living with HIV/AIDS: A randomized clinical trial protocol

et al. 2022

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Background People living with HIV (PLHIV) present impaired muscle metaboreflex, which may lead to exercise intolerance and increased cardiovascular risk. The muscle metaboreflex adaptations to exercise training in these patients are unknown. The present study aims to investigate the effects of a supervised multimodal exercise training on hemodynamic and autonomic responses to muscle metaboreflex activation in PLHIV. Methods and design In this randomized clinical trial protocol, 42 PLHIV aged 30–50 years will be randomly assigned at a ratio of 1:1 into an intervention or a control group. The intervention group will perform exercise training (3x/week during 12 weeks) and the control group will remain physically inactive. A reference group composed of 21 HIV-uninfected individuals will be included. Primary outcomes will be blood pressure and heart rate variability indices assessed during resting, mental stress, and activation of muscle metaboreflex by a digital sphygmomanometer and a heart rate monitor; respectively. Mental stress will be induced by the Stroop Color-Word test and muscle metaboreflex will be activated through a post-exercise circulatory arrest (PECA) protocol, being the latter performed without and with the application of a capsaicin-based analgesic balm in the exercised limb. Secondary outcomes will be heart rate, peripheral vascular resistance, stroke volume, cardiac output, blood lactate, anthropometric markers and handgrip maximal voluntary contraction. The intervention and control groups of PLHIV will be evaluated at baseline and after the intervention, while the HIV-uninfected reference group only at baseline. Discussion The findings of the present study may help to elucidate the muscle metaboreflex adaptations to exercise training in PLHIV. Trial registration This study will be performed at University of Rio de Janeiro State following registration at ClinicalTrials.gov as NCT04512456 on August 13, 2020.

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Effectiveness of an 8-Week Aerobic Exercise Program on Autonomic Function in People Living with HIV Taking Anti-Retroviral Therapy: A Pilot Randomized Controlled Trial

Cited by 6 publications

References 29 publications

Meditation and Aerobic Exercise Enhance Mental Health Outcomes and Pattern Separation Learning Without Changing Heart Rate Variability in Women with HIV

Meditation and Aerobic Exercise Enhance Mental Health Outcomes and Pattern Separation Learning Without Changing Heart Rate Variability in Women with HIV

Effects of Different Training Interventions on Heart Rate Variability and Cardiovascular Health and Risk Factors in Young and Middle-Aged Adults: A Systematic Review

The effects of exercise training on autonomic and hemodynamic responses to muscle metaboreflex in people living with HIV/AIDS: A randomized clinical trial protocol

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