Effectiveness of an add-on treatment with the homeopathic medication SilAtro-5-90 in recurrent tonsillitis: An international, pragmatic, randomized, controlled clinical trial

Palm, Jürgen; Kishchuk, Vasyl; Ulied, Àngels; Fernández, Joaquin Perotti; Jaegere, Sabine De; Jong, Miek C.; Keller, Thomas; Kosakovskyi, A.L.; Kompaniiets, Kira; Inga, Inga Mityuryayeva-Korniyko; Pukhlik, Sergey M.; Tretiakevych, Zoia; Weber, Stephan; Wienhold, Karin; Klement, Petra

doi:10.1016/j.ctcp.2017.05.005

Cited by 13 publications

(16 citation statements)

References 26 publications

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“…46 Adjunctive treatment is another choice wherein homoeopathy has a potential role to play in integrative patient care. 39,41,53 Homeopathic remedies are generally regarded as safe. 27,38,55,67 However, it is not absolutely devoid of risks and a few mild adverse events were reported in the reviewed studies.…”

Section: Discussion Summarymentioning

confidence: 99%

“…A study 38 on 30 patients suffering from viral tonsillitis by Malapane et al found that homeopathic complex medicine exhibited significant anti-inflammatory and pain-relieving properties without any adverse events. An international, pragmatic, randomised, controlled clinical trial by Palm et al 39 on recurrent tonsillitis with a sample size of 256 patients investigated SilAtro-5-90 (Atropinum sulfuricum, Mercurius bijodatus, Hepar sulphur, Kali bichromicum and Silicea) 'in' addition to standard treatment. They suggested an integrative treatment may bring the therapeutic benefit to patients.…”

Section: Randomised Clinical Trialsmentioning

confidence: 99%

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Efficacy of Homoeopathy in Managing Respiratory Infections beyond Doubt!—A Narrative Review

2020

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Background Coronavirus disease 2019 (COVID-19) or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is accountable for significant mortality worldwide. This virus is primarily infecting the respiratory tract and resulting in SARS. There is no precise treatment available till today. Thus, it is important to find out the alternative approach which can reduce the burden of disease. Objective The aim of this review is to summarise and appraise the findings of various studies on respiratory infections in homoeopathy. Methods A comprehensive search of the articles published during the period from 1 January 2000 to 15 June 2020 on homoeopathy and respiratory infections was carried out. Major electronic medical databases such as PubMed, Cochrane Database of Systematic Reviews, CORE-Hom and CAM-QUEST were used for the literature search. Result From the literature search 46 studies congregated out of which 9 were systematic reviews, 18 randomised contolled trials, 1 controlled clinical trial, 13 comparative cohorts, 3 single-arm cohort observational studies, 1 case series and 1 case report. The results of this review are encouraging. Homeopathic medications have a positive effect in reducing the number of attacks of respiratory infections, less antibiotic usage, tolerability and good compliance as compared to conventional treatment. Complex homeopathic medicine showed a promising role in combating respiratory infections. Homeopathy has shown an important role as adjuvant therapy. Conclusion The findings of this review seem to suggest a definite role of homeopathy beyond placebo in the treatment of various conditions of respiratory infections. Applying homeopathy as an adjunctive treatment in COVID-19 cases can be cost-effective, feasible and safe. Owing to the heterogeneity in trials, independent replications and further appraisal with rigorous designs are warranted.

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Section: Discussion Summarymentioning

confidence: 99%

Section: Randomised Clinical Trialsmentioning

confidence: 99%

Efficacy of Homoeopathy in Managing Respiratory Infections beyond Doubt!—A Narrative Review

2020

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“…The primary outcome for the model is the incremental cost per ATI averted. Estimates of the recurrence of ATIs following intervention are drawn from an open-label multi-centre randomised controlled trial of SilAtro-5-90 [ 16 ] for individuals with moderate recurrent tonsillitis in 19 study centres across Germany, Spain and the Ukraine. Moderate recurrent tonsillitis was defined as experiencing at least 3 ATIs in the prior 12 months or 2 ATIs in each of the previous 2 years.…”

Section: Methodsmentioning

confidence: 99%

“…A multicentre randomised clinical trial of patients experiencing recurrent tonsillitis found that the risk of having an ATI was significantly lower in patients treated with conventional symptomatic medication together with SilAtro-5-90 (intervention group) than in those treated with conventional symptomatic medication alone (usual care group). At the same time, the adjuvant SilAtro-5-90 plus usual care group had a significantly reduced use of antibiotic medication, and a lower number of days absent from work or school when experiencing an ATI [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Cost-effectiveness analysis for SilAtro-5-90 adjuvant treatment in the management of recurrent tonsillitis, compared with usual care only

Ostermann

Park

Jaegere

et al. 2021

Cost Eff Resour Alloc

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Purpose Antibiotics are one possible treatment for patients with recurrent acute throat infections (ATI), but effectiveness can be modest. In view of worries over antibiotic resistance, treatment pathways that reduce recurrence of ATI are essential from a public health perspective. Integrative treatment strategies can be an option but there is still a high demand to provide evidence of their cost effectiveness. Methods We constructed a 4-state Markov model to compare the cost-effectiveness of SilAtro-5-90 as adjuvant homeopathic therapy to care as usual with care as usual alone in reducing the recurrence of ATI for children and adults with suspected moderate recurrent tonsillitis. The analysis was performed from a societal perspective in Germany over a 2-year period. Results are reported separately for children < 12 and for individuals aged 12 and over. The model draws on evidence from a multi-centre randomised clinical trial that found this strategy effective in reducing recurrence of ATI. Costs in 2019 € and outcomes after 1 year are discounted at a rate of 3% per annum. Results For adults and adolescents aged 12 years and over, incremental cost per ATI averted in the adjuvant therapy group was €156.64. If individuals enter the model on average with a history of 3.33 previous ATIs, adjuvant therapy has both lower costs and better outcomes than care as usual. For children (< 12 years) adjuvant therapy had both lower costs and ATI than care as usual. The economic case is stronger if adjuvant treatment reduces surgical referral. At a hypothetical cost per ATI averted threshold of €1000 probabilistic sensitivity analysis suggests Silatro-5-90 has a 65% (adults) and 71% (children) chance of being cost-effective. Conclusion Our results indicate the importance of considering homeopathy as adjuvant therapy in the treatment of ATIs in individuals with recurrent tonsillitis from a socio-economic perspective. Further evaluation should assess how differences in uptake and sustained use of homeopathic adjuvant therapy, as well as changing patterns of antibiotic prescribing, impact on cost effectiveness.

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“…В ходе исследований было продемонстрировано значительное снижение частоты рецидивов (более чем в 2 раза) и увеличение среднего времени ремиссии (практически в 3 раза) при применении Тонзилотрена в комплексной терапии. Кроме того, использование Тонзилотрена позволило сократить частоту применения антибиотиков в 1,6 ра за [18,19].…”

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Modern Methods to Treat Chronic Tonsillitis

Рязанцев¹,

Еремина²,

Щербань³

2017

Med. sov.

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В статье отражены вопросы эпидемиологии, этиопатогенеза и классификации хронического тонзиллита. Последовательно рассматриваются современные методы лечения, в частности использования препарата Тонзилотрен в схемах терапии. Приводятся результаты международных многоцентровых рандомизированных контролируемых клинических исследований, целью которых являлось определение и оценка эффективности и переносимости препарата Тонзилотрен. Сделаны выводы о том, что Тонзилотрен является эффективным, современным средством для патогенетического лечения больных с хроническим тонзиллитом, и он может быть рекомендован в современной схеме лечения хронического тонзиллита.

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Effectiveness of an add-on treatment with the homeopathic medication SilAtro-5-90 in recurrent tonsillitis: An international, pragmatic, randomized, controlled clinical trial

Abstract: ISRCTN registry: Registration number ISRCTN19016626, registered 23 January 2013.

Cited by 13 publications

References 26 publications

Efficacy of Homoeopathy in Managing Respiratory Infections beyond Doubt!—A Narrative Review

Efficacy of Homoeopathy in Managing Respiratory Infections beyond Doubt!—A Narrative Review

Cost-effectiveness analysis for SilAtro-5-90 adjuvant treatment in the management of recurrent tonsillitis, compared with usual care only

Modern Methods to Treat Chronic Tonsillitis

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