Effectiveness of an Adjuvanted Monovalent Vaccine Against the 2009 Pandemic Strain of Influenza A(H1N1)v in Stockholm County, Sweden

Abstract

The monovalent AS03-adjuvanted influenza vaccine was highly effective in prevention of the pandemic influenza in Stockholm County. A single dose seemed to be sufficient in most, both children and adults, except in immunocompromised hosts.

A Prospective Study of the Factors Shaping Antibody Responses to the AS03-Adjuvanted Influenza A/H1N1 Vaccine in Cancer Outpatients

“…Although the HAI assay only measured the phase of virus attachment to a host cell, the MN assay confirmed that vaccine-induced antibodies prevented viral infection. Thus, most cancer patients were likely protected against influenza A/H1N1/09, although T-cell responses were not assessed [30,31]. The high seroprotection and seroconversion rates observed in our study contrasted with recent data showing poor immune responses (i.e., seroprotection and seroconversion rates Ͻ50%) in cancer patients [26,32,33].…”

2012/13 influenza vaccine effectiveness against hospitalised influenza A(H1N1)pdm09, A(H3N2) and B: estimates from a European network of hospitals

“…Among other immunocompromised populations, primarily cancer patients and transplant recipients (individuals receiving hematopoietic stem cell or solid organ transplants), single doses of both unadjuvanted and adjuvanted inactivated influenza vaccines have solicited only moderate immunological responses in adults [269,[273][274][275][276][277][278][279] and children. [280][281][282] Many of these studies found that a second dose significantly improved the proportion achieving serological protection.…”

Clinical and epidemiological findings in patients with pandemic A(H1N1) 2009 influenza in uppsala county, Sweden

“…However, a prospective population-based cohort study carried out in Stockholm County, Sweden indicated that the monovalent AS03-adjuvanted influenza vaccine was highly protective against pandemic influenza [23]. Other studies, using the same adjuvanted vaccine, have confirmed its efficiency [24,25]. On the other hand, countries with little vaccination efforts did not differ in influenza-caused morbidity or death compared with Sweden.…”