This aims of the study include assess of nursesꞌ knowledge and find out the effectiveness of the educational program among nurses about risk factors for bleeding of acute myocardial infarction in patient receiving thrombolytic therapy at coronary care unit in Al-Diwaniyah Teaching Hospital, and find out the relationship between the nurses' knowledge and their demographic variable. Methodology a pre-experimental design is applied with utilizing (one group design: pre-test and post-test) has been done at Coronary Care Unit in Al-Diwaniya Teaching Hospital. Duration of study beginning from (September 17, 2020 to April 4, 2021 ) on a non-probability (purposive) sample comprising of (40 nurses) employing in the Coronary Care Unit. The results of this study illustrated that there is a highly significant differences among the nurses' knowledge about risk factors for bleeding AMI in a patients receiving thrombolytic therapy at the score post-test compared with the score pre-test(at post -test M= 1.76 versus at pre -test M= 1.26 at p-value 0.0001) to the nurses' participation in these study. The researcher concluded that the nursesꞌ knowledge were (low), and after Implementation the educational program, the nursesꞌ knowledge were improving to (good) about risk factors for bleeding AMI in a patients receiving thrombolytic therapy at coronary care.