“…The most famous bundle, that of the Institute for Healthcare Improvement, includes elevating the head of the bed, thromboembolism prophylaxis, stress ulcer prophylaxis, daily sedative interruption and daily assessment of patients' readiness to wean from mechanical ventilation. Some institutions, however, take issue with specific components of the bundle (stress ulcer prophylaxis, for example, is associated with an increased risk of hospital-acquired pneumonia and Clostridium difficile infections [13,14]), add additional components (such as frequent oral care with chlorhexidine) or embrace complementary interventions such as selective oral or digestive decontamination, continuous aspiration of subglottic secretions or silver-coated endotracheal tubes [15][16][17][18][19][20][21].…”