Effectiveness of anticholinergic drugs compared with placebo in the treatment of overactive bladder: systematic review

Herbison, Peter; Hay‐Smith, Jean; Ellis, Gaye; Moore, Kate H.

doi:10.1136/bmj.326.7394.841

Cited by 295 publications

(179 citation statements)

References 16 publications

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“…A power calculation was based on the systematic review by Herbison, which showed that the mean Cmax in people with OAB is 360 ml with a standard deviation of 103; a crossover study with 23 people has a power to detect a di¡erence of 28% in Cmax. [Herbison et al, 2003].…”

Section: Methodsmentioning

confidence: 99%

A double‐blind, randomized controlled trial of cystometry using saline versus 0.3 M potassium chloride infusion in women with overactive bladder syndrome

Philip

Willmott

Owen

et al. 2006

Neurourology and Urodynamics

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Aim: To evaluate the e¡ect of 0.3 M potassium chloride on cystometric parameters by comparing it with normal saline as a ¢lling solution in women with overactive bladder (OAB). Patients and Methods: Twenty-three women with signi¢cant OAB symptoms underwent consecutive cystometrograms (CMGs) using 0.9% normal saline (NS) and 0.3 M potassium chloride (KCl), the order of which was randomized for each patient. Individual CMGs were performed by separate investigators and both patients and investigators were blinded to the order in which each solution was given and to the results of the other CMG. Results: Regardless of the nature of the ¢lling solution, the order in which the CMGs were performed had little in£uence on either ¢rst desire to void (FDV, mean 83.5 ml vs. 117.8 ml for ¢rst and second CMGs respectively, P ¼ 0.10) or on maximum cystometric capacity (Cmax, mean 265.0 ml vs. 264.4 ml, P ¼ 0.98). KCl produced a signi¢cant (24%) reduction in mean Cmax compared to NS (mean 228.6 ml vs. 300.8 ml, P ¼ 0.001), irrespective of the order of infusion. Conclusion: This comparative study using 0.3 M KCl versus NS as ¢lling solutions suggests that intravesical potassium may not simply act on urothelial sensory nerve endings; it may also stimulate detrusor muscle contraction. These ¢ndings may in£uence the interpretation of the potassium sensitivity test in patients with OAB symptoms, particularly in those suspected of having interstitial cystitis.

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Section: Methodsmentioning

confidence: 99%

A double‐blind, randomized controlled trial of cystometry using saline versus 0.3 M potassium chloride infusion in women with overactive bladder syndrome

Philip

Willmott

Owen

et al. 2006

Neurourology and Urodynamics

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“…Wirkung ist jedoch erheblich und liegt bei mindestens 25% (Herbison et al, 2003;Yarker et al, 1995). Aber auch Medikamente anderer Stoffgruppen zeigten gewisse Therapieerfolge, so z.B.…”

Section: Abbruchrate Dieser Medikamente Aufgrund Von Nebenwirkungen Ounclassified

Botulinumtoxin in der Urologie

Schulte-Baukloh

Knispel

2004

Urologe [A]

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“…[16][17][18][19] We theorized that IC/BPS may have an association with low back pain; and for a number of patients, the condition may subside when their low back condition improves. It is unknown if there is a casual relationship, but the potential impact of IC/BPS on patients' lives suggests that we consider a potential relationship.…”

Section: Introductionmentioning

confidence: 99%

Chiropractic care of interstitial cystitis/painful bladder syndrome associated with pelvic lumbar spine dysfunction: a case series

Cashley¹,

Cashley²

2012

Journal of Chiropractic Medicine

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Objective: The purpose of this case series is to describe findings for patients with bladder pain syndrome (BPS) or interstitial cystitis (IC) who responded positively under chiropractic care. Clinical Features: Eight cases were selected retrospectively reviewed from 2 independent chiropractic clinics in Scotland. Cases were selected if patients reported bladder dysfunction problems and responded positively to chiropractic care. The cases in this report describe the range of patients affected by this condition. Each patient was treated using chiropractic methods that were specific to the individual case. Intervention and Outcomes: The patients selected for this case series showed positive response to chiropractic care over various lengths of time and numbers of treatments. Some of the chiropractic patients who had chronic spinal conditions had reoccurrence of bladder symptoms during an exacerbation of mechanical spinal problems. Conclusion: This case series highlights that bladder and urinary problems may be associated with spinal dysfunction for some patients.

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Effectiveness of anticholinergic drugs compared with placebo in the treatment of overactive bladder: systematic review

Abstract: Objective To determine the effectiveness of anticholinergic drugs for the treatment of overactive bladder syndrome.

Cited by 295 publications

References 16 publications

A double‐blind, randomized controlled trial of cystometry using saline versus 0.3 M potassium chloride infusion in women with overactive bladder syndrome

A double‐blind, randomized controlled trial of cystometry using saline versus 0.3 M potassium chloride infusion in women with overactive bladder syndrome

Botulinumtoxin in der Urologie

Chiropractic care of interstitial cystitis/painful bladder syndrome associated with pelvic lumbar spine dysfunction: a case series

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