Effectiveness of Aqueous and Alcoholic Extracts of Barberry, Jujube, and Saffron Against Oxidative Stress in Streptozotocin-Induced Diabetic Rats

Valavi, Maryam; Mezginejad, Fateme; Haghighi, Fatemeh; Hemmati, Mina; Zarban, Asghar; Gask, Elham Rabiei

doi:10.5812/modernc.11162

Cited by 4 publications

(2 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this way, it directly scavenges superoxide-free radicals in the system, increases the expression of sirtuin 1, and decreases oxidative stress by reducing expression of nicotinamide and adenine dinucleotide phosphate oxidase which are critical sources for ROS production in cells. In line with the present research, the review study performed by Imenshahidi and co-workers showed that barberry and resveratrol might suppress TNF-α, IL-1, nitric oxide (NO), and MDA through the aforementioned mechanism (9,19,42,43). According to this mechanism, resveratrol and barberry increase SOD and TAC levels.…”

Section: Discussionsupporting

confidence: 88%

See 1 more Smart Citation

Effect of hydroalcoholic extract of Berberis integerrima and resveratrol on ovarian morphology and biochemical parameters in Letrozole-induced polycystic ovary syndrome rat model: An experimental study

Ashkar¹,

Eftekhari²,

Tanideh³

et al. 2020

IJRM

View full text Add to dashboard Cite

Background: Resveratrol and Berberis integerrima (B. integerrima) are known to be natural antioxidants and regulators of human metabolism. However, the effects of resveratrol and B. integerrima on the ovarian morphology in polycystic ovary syndrome (PCOS) are not obvious. Objective: This study aimed to determine the effect of the hydroalcoholic extract of B. integerrima in combination with resveratrol on some biochemical parameters and ovarian morphology in the letrozole-induced PCOS rat. Materials and Methods: Seventy adult female Sprague-Dawley rats aged 10-12 weeks weighing 200 ± 20 gr were randomly divided into seven groups (n = 10/each). Group I): normal; Group II): vehicle; Group III): letrozole-induced PCOS 1 mg/kg letrozole orally, rats receiving 1 cc normal saline orally; Group IV): PCOS + receiving 150 mg/kg metformin orally; Group V): PCOS + receiving 20 mg/kg resveratrol orally; Group VI): PCOS + 3 gr/kg barberry orally; and Group VII): PCOS + receiving 3 gr/kg barberry and 20 mg/kg resveratrol orally. All animals were followed-up for 63 days. The biochemical parameters and histological assessments of ovaries were performed. Results: Resveratrol alone and/or in combination with B. integerrima treatment in rats led to a significant decrease in low-density lipoprotein, triglyceride, malondialdehyde , and tumor necrosis factor-alpha concentrations (p = 0.02). The groups IV, V, VI, and VII showed a decrease in insulin resistance and an increase in the superoxide dismutase, total antioxidant capacity, and high-density lipoprotein (p = 0.01). No significant difference was observed between the level of serum glucose in the treatment groups. Number of cystic follicles had a significant decrease in barberry, resveratrol, and their combination groups (p < 0.001). Conclusion: Resveratrol, B. integerrima, and their combination as natural products with fewer side effects might be effective as an alternative medicine in treatment of PCOS. Key words: Barberry, Resveratrol, Polycystic ovary syndrome, Ovary, Rat.

show abstract

Section: Discussionsupporting

confidence: 88%

“…SOD and TAC were determined via the enzymatic colorimetric method with the microplate reader using enzymatic kits (ZV-TAC-A96) purchased from Zellbio Co., Germany. Additionally, MDA activity was determined via spectrophotometric analysis using thiobarbituric acid reactive substances (TBARS) method (19).…”

Section: Biochemical Markersmentioning

confidence: 99%