Effectiveness of autologous chondrocyte transplantation for hyaline cartilage defects in knees: a rapid and systematic review

Abstract

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Magnetic Resonance Imaging of Chondrocytes Labeled with Superparamagnetic Iron Oxide Nanoparticles in Tissue-Engineered Cartilage

“…Moreover, iron oxide labeling of chondrocytes may have immediate applicability in current tissue repair therapies such as autologous chondrocyte implantation. [39][40][41][42][43] Heymer et al 44 were the first to report on SPIO labeling specifically for the purposes of cartilage tissue engineering. Their studies showed that bone marrow-derived stem cells could still differentiate chondrogenically while retaining intracellular iron oxide, thereby permitting MRI detection within 3D collagen type I hydrogel constructs.…”

Safety of, and biological and functional response to, a novel metallic implant for the management of focal full‐thickness cartilage defects: Preliminary assessment in an animal model out to 1 year

“…2 If the injury is initially restricted to the aneural cartilage, an extended period of uninhibited use may separate the inciting incident from the onset of clinical signs. 3,4 Consequently, many affected individuals may be middle-aged or older on first presentation.…”

“…6,7 Osteochondral autografts are technically demanding, have associated donor site morbidity, and work best in younger patients, 5 and allografts have the added risks of disease transmission and immune-mediated rejection. 8 While greater than 70% of patients undergoing autologous chondrocyte transplantation have had a good or excellent outcome 2 or more years postsurgery, 3 the procedure is lengthy and expensive, it is contraindicated in the presence of existing osteoarthritis, 9,10 and it has a demanding convalescence program.…”

Focal articular cartilage defects of the knee: surgical treatment

“…Systematic reviews "Effectiveness of autologous chondrocyte transplantation for hyaline cartilage defects in knees: a rapid and systematic review" [2].…”