ymphedema is an inflammatory condition caused by the accumulation of lymphatic fluid due to damage to the lymphatic system. There are 2 classifications of lymphedema: primary, which is caused by malformation of lymph vessels or nodes, and secondary, which is due to trauma, chronic lymphatic system overload, or cancer and its treatments. This article focuses on cancer-related lymphedema, which can develop within weeks, months, or years following oncologic treatments. 1 Herein we present an overview of epidemiology, risk factors, history and physical examination for clinical diagnosis, as well as criterion-standard management for this condition in the primary care setting.This article is eligible for Mainpro+ certified Self-Learning credits. To earn credits, go to https://www.cfp.ca and click on the Mainpro+ link.