Effectiveness of chemoprophylaxis and other determinants of malaria in travellers to Kenya

Muehlberger,; Jelinek,; Schlipkoeter,; Sonnenburg, V.; Nothdurft,

doi:10.1046/j.1365-3156.1998.00235.x

Cited by 34 publications

(11 citation statements)

References 10 publications

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“…A predominance of imported malaria infections in male patients has been documented before ( 2 , 5 , 18 , 19 ); men are often also less compliant with chemoprophylaxis than women ( 5 ). We also found that children <6 years of age had a significantly higher risk of being reported with malaria.…”

Section: Discussionmentioning

confidence: 84%

Malaria Risk in Travelers

Askling

Nilsson

Tegnell

et al. 2005

Emerg. Infect. Dis.

106

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Section: Discussionmentioning

confidence: 84%

Malaria Risk in Travelers

Askling

Nilsson

Tegnell

et al. 2005

Emerg. Infect. Dis.

106

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“…The estimates of the prophylactic effectiveness are based on a review of literature on travel medicine malaria studies [19-21]. …”

Section: Methodsmentioning

confidence: 99%

Cost-effectiveness analysis of malaria chemoprophylaxis for travellers to West-Africa

et al. 2010

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BackgroundThe importation of malaria to non-endemic countries remains a major cause of travel-related morbidity and a leading cause of travel-related hospitalizations. Currently they are three priority medications for malaria prophylaxis to West Africa: mefloquine, atovaquone/proguanil and doxycycline. We investigate the cost effectiveness of a partial reimbursement of the cheapest effective malaria chemoprophylaxis (mefloquine) for travellers to high risk areas of malaria transmission compared with the current situation of no reimbursement.MethodsThis study is a cost-effectiveness analysis based on malaria cases imported from West Africa to Switzerland from the perspective of the Swiss health system. We used a decision tree model and made a literature research on the components of travel related malaria. The main outcome measure was the cost effectiveness of malaria chemoprophylaxis reimbursement based on malaria and deaths averted.ResultsUsing a program where travellers would be reimbursed for 80% of the cost of the cheapest malaria chemoprophylaxis is dominant (i.e. cost saving and more effective than the current situation) using the assumption that currently 68.7% of travellers to West Africa use malaria chemoprophylaxis. If the current usage of malaria chemoprophylaxis would be higher, 82.4%, the incremental cost per malaria case averted is € 2'302. The incremental cost of malaria death averted is € 191'833.The most important factors influencing the model were: the proportion of travellers using malaria chemoprophylaxis, the probability of contracting malaria without malaria chemoprophylaxis, the cost of the mefloquine regimen, the decrease in the number of travellers without malaria chemoprophylaxis in the reimbursement strategy.ConclusionsThis study suggests that a reimbursement of 80% of the cost of the cheapest effective malaria chemoprophylaxis (mefloquine) for travellers from Switzerland to West Africa is highly effective in terms of malaria cases averted and is cost effective to the Swiss health system. These data are relevant to discussions about the cost effectiveness of malaria chemoprophylaxis reimbursement for vulnerable groups such as those visiting friends and relatives who have the highest risk of malaria, who are least likely to use chemoprophylaxis.

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“…Although Hong Kong enjoys a healthcare infrastructure similar to those of other developed nations, at the time of this assessment relatively few organized programmes provided specialized pre-travel services. The availability of effective interventions to reduce travel health risks abroad [14][15][16][17][18][19] and the high frequency of travel among Hong Kong residents underscore the need for travel medicine services in Hong Kong. In this study we assessed the travel health care needs of Chinese residents in Hong Kong by examining travel-related health problems of returning residents and by understanding their use of travel health services before or after travel.…”

Section: Existing Travel Medicine Services In Hong Kongmentioning

confidence: 99%

Travel-related health problems of Hong Kong residents: Assessing the need for travel medicine services

Abdullah

Hamer

2006

Travel Medicine and Infectious Disease

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Effectiveness of chemoprophylaxis and other determinants of malaria in travellers to Kenya

Abstract: Malaria importation from Kenya could be reduced substantially (34%) by eliminating inappropriate medical advice.

Cited by 34 publications

References 10 publications

Malaria Risk in Travelers

Malaria Risk in Travelers

Cost-effectiveness analysis of malaria chemoprophylaxis for travellers to West-Africa

Travel-related health problems of Hong Kong residents: Assessing the need for travel medicine services

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