Effectiveness of Chinese herbal medicine combined with Western medicine on deferring dialysis initiation for nondialysis chronic kidney disease stage 5 patients: a multicenter prospective nonrandomized controlled study

Wu, Yifan; Li, Chuang; Zhang, Lei; Zou, Chuan; Xu, Peng; Wen, Zehuai; Ouyang, Wei; Yang, Ning; Zhang, Min; Lin, Qian; Lu, Fuhua; Wang, Lixin; Bao, Kun; Zhao, Daixin; Fu, Lizhe; Guo, Xinfeng; Yang, Lihong; Ou, Aihua; He, Zhiyao; Weng, Heng; Li, Jianmin; Shi, Wei; Wang, Xiaoqin; Song, Limei; Zhan, Yongli; Sun, Wei; Wei, Lianbo; Wang, Niansong; Gui, Dingkun; Zhan, Jihong; Lü, Ying; Chen, Hongyu; Liu, Yuning; Yang, Hongtao; Chen, Ming; Wang, Yiping; Zhang, Peiqing; Deng, Yulin; Meng, Lanfen; Cheng, Xin; Li, Feng; Yu, Dajun; Xu, Dianqing; Fang, Jingai; Li, Hongyan; Fu, Junzhou; Li, Wenge; Zhao, Jinghong; Huang, Yuping; Lu, Zhaoyu; Su, Guobin; La, Zhang; Qin, Xindong; Xu, Yuan; Yu, Peng; Hou, Huilian; Deng, Lili; Liu, Hui; Jie, Xina; Liu, Lichang; Tang, Fang; Pei, Hongfei; Li, Ping; Mao, Wei; Liu, Xusheng

doi:10.21037/atm-21-871

Cited by 12 publications

(7 citation statements)

References 54 publications

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“…In our study, we found that circ_0139658 increased expression in RA‐FLSs; functionally, silencing of circ_0139658 impaired the proliferation, migration, invasion, and inflammation in RA‐FLSs. To date, the combination of Chinese herbal medicine and Western medicine has gained great popularity in the treatment of diseases (Wu et al., 2021). Here, we proved that circ_0139658 overexpression abolished the suppressing effects of Brucine on RA‐FLS dysfunction and inflammation.…”

Section: Discussionmentioning

confidence: 99%

Brucine alleviates fibroblast‐like synoviocytes dysfunction and inflammation by regulating YY1 during rheumatoid arthritis

Zhang,

Wang,

2024

Chem Biol Drug Des

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Brucine is a weak alkaline indole alkaloid with wide pharmacological activities and has been identified to protect against rheumatoid arthritis (RA) process. Circular RNAs (circRNAs) are also reported to be involved in the pathogenesis of RA. Here, we aimed to probe the role and mechanism of Brucine and circ_0139658 in RA progression. The fibroblast‐like synoviocytes of RA (RA‐FLSs) were isolated for functional analysis. Cell proliferation, apoptosis, invasion, migration, as well as inflammatory response were evaluated by CCK‐8 assay, EdU assay, flow cytometry, transwell assay, and ELISA analysis, respectively. qRT‐PCR and western blotting analyses were utilized to measure the levels of genes and proteins. The binding between miR‐653‐5p and circ_0139658 or Yin Yang 1 (YY1), was verified using dual‐luciferase reporter and RNA pull‐down assays. Brucine suppressed the proliferation, migration, and invasion of RA‐FLSs, and alleviated inflammation by reducing the release of pro‐inflammatory factors and macrophage M1 polarization. RA‐FLSs showed increased circ_0139658 and YY1 levels and decreased miR‐653‐5p levels. Circ_0139658 is directly bound to miR‐653‐5p to regulate YY1 expression. Brucine treatment suppressed circ_0139658 and YY1 expression but increased YY1 expression in RA‐FLSs. Functionally, circ_0139658 overexpression reversed the suppressing effects of Brucine on RA‐FLS dysfunction and inflammation. Moreover, circ_0139658 silencing alleviated the dysfunction and inflammation in RA‐FLSs, which were reverted by YY1 overexpression. Brucine suppressed the proliferation, migration, invasion, and inflammation in RA‐FLSs by decreasing YY1 via circ_0139658/miR‐653‐5p axis.

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Section: Discussionmentioning

confidence: 99%

Brucine alleviates fibroblast‐like synoviocytes dysfunction and inflammation by regulating YY1 during rheumatoid arthritis

Zhang,

Wang,

2024

Chem Biol Drug Des

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“…Co-administration of antidiabetic drugs (e.g., biguanides, sulfonylureas, glinides) and herbs/dietary supplement (e.g., AR, Rehmannia glutinosa , Pueraria lobata and their compound preparation) is very popular in clinical practice in some countries (e.g., China, Japan) ( Cui et al, 2018 ; Wu et al, 2021 ; Liu et al, 2023 ). DAPA is frequently co-administrated with some popular antidiabetic herbs (e.g., AR and its compound preparation) in China.…”

Section: Discussionmentioning

confidence: 99%

Effect of Astragali radix extract on pharmacokinetic behavior of dapagliflozin in healthy and type 2 diabetic rats

Du,

Hu,

Liang

et al. 2023

Front. Pharmacol.

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Objective: This study aimed to investigate effect of antidiabetic herb Astragali Radix (AR) on pharmacokinetic behavior of dapagliflozin (DAPA) in healthy rats and type 2 diabetes mellitus (T2DM) rats.Methods: The T2DM rats were induced by high-fat diet (HFD) and intraperitoneal injection of streptozotocin (STZ). Concentrations of DAPA in healthy and T2DM rat plasma were determined by UPLC-MS/MS method. Effect of AR extract (ARE) on pharmacokinetic behavior of DAPA in healthy and T2DM rats was evaluated, respectively.Results: The diabetes status and co-administrated with ARE significantly affected pharmacokinetic behaviors of DAPA in the rats. Compared to that in healthy rats, tmax of DAPA significantly shortened, its Cmax significantly increased in T2DM rats, and its t1/2, V, AUC, CL and MRT kept unchanged. When ARE was co-administrated with DAPA, Cmax of DAPA significantly increased, its tmax and MRT significantly decreased, and its t1/2, V, AUC and CL kept unchanged in healthy rats. tmax and Cmax of DAPA significantly decreased, its t1/2 and V significantly increased, and its AUC, CL and MRT were unchanged in T2DM rats when ARE was co-administrated with DAPA. Co-administration of DAPA and ARE promoted absorptive rate of DAPA, increased its extravascular tissue distribution, and prolonged its duration of action. ARE did not cause accumulation of DAPA in vivo.Conclusion: Both disease status of T2DM and co-administration of ARE affect pharmacokinetic behavior of DAPA in vivo. Potential pharmacokinetic interactions may occur in vivo when herbs and drugs are co-administrated, which may affect efficacy and safety of drugs.

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“…According to studies (2015-2021), CKD patients use traditional medicine alone or in conjunction with conventional medicine (Zhao et al 2021). Current therapies using commercially available drugs, such as ACEIs, angiotensin II receptor blockers and calcium channel blockers, generally only delay the progression of CKD (Wu et al 2021). Therefore, conventional doctors rely on plant-based medicines as a supplementary option to conventional medicine for an array of human ailments (Xego et al 2021).…”

Section: Interactions Between Herbal Medicines and Western Medicinesmentioning

confidence: 99%

“…In some cases, administering the incorrect dosage can result in toxicity.The ability of medicinal plants to boost the body's natural antioxidant defence mechanisms is often responsible for their beneficial effect on kidney disease(Khan et al 2022). Previous studies conducted in patients with CKD in Tanzania, Peru and China found frequent use of medicinal plants(Herrera- Añazco et al 2019;Stanifer et al 2015;Wu et al 2021). However, the characteristics of their use could be different in the South African population because of cultural differences between the countries.…”

mentioning

confidence: 99%

Identification of medicinal plants used for chronic kidney disease: An update of reported literature in South Africa

Govender

Singh

Coopoosamy

et al. 2023

JOMPED

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Background: Chronic kidney disease (CKD) is a debilitating condition that is becoming more common around the world, as well as a financial and social burden on healthcare systems. If not treated with kidney replacement therapies, kidney failure, the final stage of CKD, can be fatal. Chronic kidney disease patients are now seeking the use of alternative remedies, including medicinal plants, as the primary source of healthcare.Aim: This review aimed to evaluate the use of medicinal plants in the treatment of CKD and other associated kidney diseases in South Africa.Method: This article summarises previous research (2010–2021) on the impact of traditional plant-based medicine in CKD treatment and identifies the context between traditional and conventional medicines. Various scientific databases were used to source key literature.Results: The findings of this study revealed 10 medicinal plant species from nine different botanical families that are commonly used for the treatment of CKD and other kidney-related diseases in South Africa. In addition, the study demonstrated that despite medicinal plants having toxic impacts, they were still the preferred choice of medication for CKD, especially in developing countries.Conclusion: It is crucial to validate the balance between the risks and benefits of medicinal plants in CKD treatment to further enhance the credibility of medical plants in drug development.Contribution: This study contributes to the existing knowledge of medicinal plants used in CKD treatment primarily in South Africa.

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Effectiveness of Chinese herbal medicine combined with Western medicine on deferring dialysis initiation for nondialysis chronic kidney disease stage 5 patients: a multicenter prospective nonrandomized controlled study

Abstract: Wu et al. CHM on deferring dialysis initiation for stage 5 CKD patients

Cited by 12 publications

References 54 publications

Brucine alleviates fibroblast‐like synoviocytes dysfunction and inflammation by regulating YY1 during rheumatoid arthritis

Brucine alleviates fibroblast‐like synoviocytes dysfunction and inflammation by regulating YY1 during rheumatoid arthritis

Effect of Astragali radix extract on pharmacokinetic behavior of dapagliflozin in healthy and type 2 diabetic rats

Identification of medicinal plants used for chronic kidney disease: An update of reported literature in South Africa

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