Effectiveness of Chinese herbal medicine Zhi Shi Xiao Pi Wan on adult diabetic gastroparesis: a systematic review and meta-analysis

Abstract

Chinese herbal medicine formula Zhi Shi Xiao Pi Wan (ZSXPW) is commonly used for gastrointestinal diseases. Previous research showed ZSXPW also suggested for diabetic gastroparesis (DGP) treatment. The aim of this study is to evaluate the effectiveness and safety of ZSXPW in treating adult DGP. Six databases, including Pubmed, Cochrane Library, EMBASE, China Network Knowledge Infrastructure (CNKI), Wanfang, and Chinese Scientific Journals were searched from their inceptions to November 2021. Only randomized control trials (RCTs) evaluating ZSXPW for adult DGP were included in this review. Two investigators independently evaluated and extracted the data. Total 11 RCTs and 802 participants were included in the review. In these studies, ZSXPW was compared with oral cisapride, domperidone, and mosapride citrate tablets. The outcomes of effective rate, stomach emptying time, stomach emptying rate, motilin, gastrin, somatostatin, vasoactive intestinal peptide, and adverse events were analyzed. The effective rate of ZSXPW is higher than other pharmacotherapies (RR:1.24, 95% CI [1.16,1.32]). The results showed intervention group has better effect on gastric emptying time used (MD: -0.51, 95% CI [-0.81, -0.21]) and gastric emptying rate (MD: 19.32, 95% CI [12.82, 25.83]) than the comparison group. The meta-analysis results showed ZSXPW is effective on adult DGP.