Effectiveness of Cinnamomum cassia against Liver and Kidney Biochemical Assay and Hematology in Bisphenol-A Induced Rats

Abstract

B isphenolA (BPA) is an organic chemical commonly used in the manufacturing of polycarbonates, epoxy resins, and other polymer products as a monomer or additive. Its most important applications are the formation of polyacrylate resins, polyester resins, flame retardants, polysulfone resins, and polyethylene resin (Huang et al., 2011;Almeida et al., 2018).Although, it is a well-studied endocrine disruptor Abstract | Bisphenol-A (BPA) exhibits toxic, endocrine, mutagenic and carcinogenic effects in living organisms. However, some dietary elements, such as cinnamon is gaining attention as it has antioxidant effects both in vivo and in vitro. The present research study was designed to see the effect of cinnamon against BPA induced Sprague Dawley rats. In the study Sprague Dawley rats of an average 300 gram body weigt were used. The rats were divided into control and treated groups. The control group was comprised of normal control (C; untreated), vehicle control (P; treated with 1ml olive oil), and positive control (BG1; only treated with BPA). Treated groups were included the pretreated group (CG2; pretreated with C. cassia at 225 mg/ kg/BW 24 hours before BPA) and the post-treated group (CG3; post-treated with C. cassia at 225 mg/kg/ BW 24 hours before BPA). In the experiment Sprague Dawley rats were fed by BPA that was followed by the intake of C. cassia at 225 mg/kg/BW of the rat. Liver (Total bilirubin, alkaline phosphate test, Lactate dehydrogenase, and alanine amino transferase) and kidney (Blood Urea Nitrogen, Creatinine, and Uric acid) biomarkers were assessed. The highest levels of ALT and ALP were linked to liver injury and a higher weight in the liver were observed in BPA treated rats as compared to the control group. Similarly, an increase in blood parameters were recorded in BPA treated rats followed by post -treated rats and pre-treated group. It was concluded by the study that BPA have pronounced adverse effects in the exposed animals particularly in BPA and cinnamon post-treated rats as compared to pre-treated rats.