Effectiveness of combinations of Ayurvedic drugs in alleviating drug toxicity and improving quality of life of cancer patients treated with chemotherapy

Deshmukh, Vineeta; Kulkarni, Arvind; Bhargava, Sudhir; Patil, Tushar; Ramdasi, Vijay; Gangal, Sudha G.; Godse, Vasanti; Datar, Shrinivas; Gujar, Shweta; Sardeshmukh, Sadanand

doi:10.1007/s00520-014-2294-0

Cited by 18 publications

(9 citation statements)

References 15 publications

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“…For example, several conventional oncology hospitals have established adjunct Ayurveda/AYUSH clinics to integrate relevant treatments with the goals of improving quality of life among patients with cancer. In addition, an Ayurvedic cancer care hospital in Pune, India integrates Ayurvedic drugs in coordination with modern oncology treatments such as chemotherapy, with some reported preliminary benefit 100 …”

Section: Examples Of Progress and Challenges Of Integrating Tcim And ...mentioning

confidence: 99%

Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Mao

Pillai

Andrade

et al. 2021

CA A Cancer J Clinicians

232

103

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The increase in cancer incidence and mortality is challenging current cancer care delivery globally, disproportionally affecting low‐ and middle‐income countries (LMICs) when it comes to receiving evidence‐based cancer prevention, treatment, and palliative and survivorship care. Patients in LMICs often rely on traditional, complementary, and integrative medicine (TCIM) that is more familiar, less costly, and widely available. However, spheres of influence and tensions between conventional medicine and TCIM can further disrupt efforts in evidence‐based cancer care. Integrative oncology provides a framework to research and integrate safe, effective TCIM alongside conventional cancer treatment and can help bridge health care gaps in delivering evidence‐informed, patient‐centered care. This growing field uses lifestyle modifications, mind and body therapies (eg, acupuncture, massage, meditation, and yoga), and natural products to improve symptom management and quality of life among patients with cancer. On the basis of this review of the global challenges of cancer control and the current status of integrative oncology, the authors recommend: 1) educating and integrating TCIM providers into the cancer control workforce to promote risk reduction and culturally salient healthy life styles; 2) developing and testing TCIM interventions to address cancer symptoms or treatment‐related adverse effects (eg, pain, insomnia, fatigue); and 3) disseminating and implementing evidence‐based TCIM interventions as part of comprehensive palliative and survivorship care so patients from all cultures can live with or beyond cancer with respect, dignity, and vitality. With conventional medicine and TCIM united under a cohesive framework, integrative oncology may provide citizens of the world with access to safe, effective, evidence‐informed, and culturally sensitive cancer care.

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Section: Examples Of Progress and Challenges Of Integrating Tcim And ...mentioning

confidence: 99%

Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Mao

Pillai

Andrade

et al. 2021

CA A Cancer J Clinicians

232

103

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“…Some studies have also demonstrated the effectiveness of ayurvedic drugs given in combinations for those cancer patients treated with chemotherapy for alleviating the toxic side effects caused by the drugs and thereby improving their quality of life and survival time. Further, these herbo-mineral formulations and supportive approaches have led to a signi icant reduction in drug toxicity and associated complications (Deshmukh et al, 2014;Mondal et al, 2014;Metri et al, 2013). This is a literature evidence on treatment of cancer patients treated by radical oncological surgeries and adjuvant medication similar to the current presentation.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness Of Siddha Formulations In Treating Breast Cancer: An Evidence-Based Case Series

Gouthaman

Saravanan

Narayanan

et al. 2021

ijrps

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Breast cancer is one of the top-ranked cancers affecting women in the world. Although there are approved standard regimens for treatment, due to toxicological side effects, there is a demand for novel anti-cancer drugs with minimal adverse effects leading to the emergence of Indian Systems of Medicine. Natural treatment modalities such as Siddha, Ayurveda and Unani are emerging and have been given gaining importance in recent times. They have been in vogue for centuries together and have shown better prognosis over a period of time with lesser toxicity and admiring oncological results. The presentation is an evidence-based report on the cure of breast cancer using Siddha chemotherapeutic formulations.

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“…These findings can be used to develop DSNs for human use. 20 Treatment of cancer patients with herbo-mineral and metallic Ayurvedic drugs has been reported to significantly reduce the toxic effects of chemotherapy on various symptoms, and to have improved QoL, 21 , 22 although no positive effects on hematological parameters could be demonstrated. Various herbal medicines have also been tested in cancer patients treated with chemotherapy, and these have been used to reduce chemotherapy-induced nausea and vomiting, to improve patients’ QoL and to allow their subsequent chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Positive effects on hematological and biochemical imbalances in patients with metastatic breast cancer stage IV, of BP-C1, a new anticancer substance

Lindkær-Jensen¹,

Larsen²,

Habib-Lindkær-Jensen³

et al. 2015

DDDT

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A benzene-poly-carboxylic acid complex with cis-diammineplatinum(II) dihydrocholride, BP-C1 is currently used in clinical trials in treating metastatic breast cancer. BP-C1 controls tumor growth with a few mild side-effects, improving quality of life.MethodsThe data consisted of prospectively collected laboratory results from 47 patients in two controlled clinical trials of daily intramuscular injections of BP-C1 for 32 days. Study I was performed as an open, nonrandomized, Phase I dose–response, multicenter study with a three-level, between-patient, response surface pathway design. The second study was a randomized, double-blind, and placebo-controlled, multicenter study with a stratified semi-crossover design.ResultsHemoglobin (Hb) and hematocrit (Hct) increased significantly (P<0.01) during BP-C1 treatment, while red blood cell (RBC) count increased but not significantly. The most pronounced increase in Hb, RBC, Hct, and white blood cell (WBC) was in anemic patients (P≤0.01). WBC count and neutrophils increased significantly (P=0.01) in the overall data. WBCs and neutrophils (P<0.01), eosinophils (P=0.05) and monocytes (P<0.01) increased significantly and markedly in patients with lowest baseline levels. Additionally, low levels of thrombocytes significantly increased. No changes in liver parameters, amylase, glucose, creatinine, or albumin, were detected except for albumin in the subgroup with low baseline levels, where levels increased significantly (P=0.04). An increase in K+, Ca2+, and PO43− was most pronounced in patients with low baseline levels (P≤0.02). A similar pattern detected for Mg2+, prothrombin time (PT), coagulation factors II, VII, X (KFNT), and C-reactive protein (CRP), which increased significantly (P≤0.05) in the groups with the lowest values.ConclusionOur findings support the safety profile of BP-C1 use in cancer patients. BP-C1 did not induce anemia, infection, bleeding, hepatic insufficiency or electrolyte imbalances. In contrast, BP-C1 corrected abnormalities. No hematological and biochemical toxicity was observed.

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Effectiveness of combinations of Ayurvedic drugs in alleviating drug toxicity and improving quality of life of cancer patients treated with chemotherapy

Cited by 18 publications

References 15 publications

Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Effectiveness Of Siddha Formulations In Treating Breast Cancer: An Evidence-Based Case Series

Positive effects on hematological and biochemical imbalances in patients with metastatic breast cancer stage IV, of BP-C1, a new anticancer substance

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